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Prosalpha3T Proteasome alpha3 subunit, Testis-specific [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43679, updated on 10-May-2024

Summary

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Official Symbol
Prosalpha3Tprovided by FlyBase
Official Full Name
Proteasome alpha3 subunit, Testis-specificprovided by FlyBase
Primary source
FLYBASE:FBgn0261395
Locus tag
Dmel_CG1736
See related
AllianceGenome:FB:FBgn0261395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
alpha3T; CG1736; Dmel\CG1736; Pros20S-alpha3t; prosalpha3T
Summary
Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Located in male germ cell nucleus. Is expressed in individualization stage spermatid; mid-late elongation-stage spermatid; spermatid; and spermatozoon. Orthologous to human PSMA4 (proteasome 20S subunit alpha 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Prosalpha3T in Genome Data Viewer
Location:
100B3-100B3; 3-102 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31122527..31123415, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (26948249..26949137, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene mayo Neighboring gene uncharacterized protein Neighboring gene Ketchup

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The testis-specific proteasome subunit Prosalpha6T of D. melanogaster is required for individualization and nuclear maturation during spermatogenesis. Zhong L, et al. Development, 2007 Oct. PMID 17728345
  2. Importin-9 regulates chromosome segregation and packaging in Drosophila germ cells. Palacios V, et al. J Cell Sci, 2021 Apr 1. PMID 33632744, Free PMC Article
  3. Toward detecting and identifying macromolecules in a cellular context: template matching applied to electron tomograms. Bohm J, et al. Proc Natl Acad Sci U S A, 2000 Dec 19. PMID 11087814, Free PMC Article
  4. The ubiquitin proteasome system acutely regulates presynaptic protein turnover and synaptic efficacy. Speese SD, et al. Curr Biol, 2003 May 27. PMID 12781128
  5. On the Origin and Evolution of Drosophila New Genes during Spermatogenesis. Su Q, et al. Genes (Basel), 2021 Nov 15. PMID 34828402, Free PMC Article

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in male germ cell nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, alpha-subunit complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome alpha3 subunit, Testis-specific
Names
20s proteasome
CG1736-PA
Prosalpha3T-PA
proteasome 20S alpha3t subunit
proteasome alpha3T subunit

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31122527..31123415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143586.3 → NP_651843.1  proteasome alpha3 subunit, Testis-specific [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651843.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3DN24, Q8IS89, Q9VA12
    Related
    FBpp0085100
    Conserved Domains (2) summary
    PTZ00246
    Location:1 → 241
    PTZ00246; proteasome subunit alpha; Provisional
    cl00467
    Location:3 → 218
    Ntn_hydrolase; The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VA12.1 Q9VA12

Gene LinkOut

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