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slc1a1 solute carrier family 1 member 1 [ Danio rerio (zebrafish) ]

Gene ID: 436939, updated on 5-Jan-2022

Summary

Official Symbol
slc1a1provided by ZNC
Official Full Name
solute carrier family 1 member 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040718-414
See related
Ensembl:ENSDARG00000020212
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
EAAT3; SLC1A2a; zgc:91959
Summary
Predicted to enable L-glutamate transmembrane transporter activity; cysteine transmembrane transporter activity; and glutamate:sodium symporter activity. Predicted to be involved in L-aspartate transmembrane transport and L-glutamate import across plasma membrane. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in cerebellum; optic tectum; and telencephalon. Human ortholog(s) of this gene implicated in dicarboxylic aminoaciduria and schizophrenia 18. Orthologous to human SLC1A1 (solute carrier family 1 member 1). [provided by Alliance of Genome Resources, Nov 2021]
Orthologs
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Genomic context

See slc1a1 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
13
Annotation release Status Assembly Chr Location
106 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (69496293..69521477, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (69258243..69283288, complement)
103 previous assembly Zv9 (GCF_000002035.4) 7 NC_007118.5 (72213224..72238389, complement)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene GABA(A) receptor-associated protein b Neighboring gene uncharacterized LOC103911445 Neighboring gene spermatogenesis associated 6-like Neighboring gene RAP1, GTP-GDP dissociation stimulator 1 Neighboring gene tetraspanin 5a

Genomic regions, transcripts, and products

Expression

  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

General gene information

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables L-glutamate transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables cysteine transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables glutamate:sodium symporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables neutral amino acid transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables symporter activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in L-aspartate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-glutamate import across plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in L-glutamate transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
excitatory amino acid transporter 3
Names
solute carrier family 1 (neuronal/epithelial high affinity glutamate transporter, system Xag), member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001002666.1NP_001002666.2  excitatory amino acid transporter 3

    See identical proteins and their annotated locations for NP_001002666.2

    Status: VALIDATED

    Source sequence(s)
    BC076553
    UniProtKB/TrEMBL
    D7RVR6, Q6DG02
    Related
    ENSDARP00000124867.1, ENSDART00000148465.3
    Conserved Domains (1) summary
    pfam00375
    Location:23470
    SDF; Sodium:dicarboxylate symporter family

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    69496293..69521477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021477460.1XP_021333135.1  excitatory amino acid transporter 3 isoform X1

    Conserved Domains (1) summary
    cl00573
    Location:23302
    SDF; Sodium:dicarboxylate symporter family
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