cryabb crystallin, alpha B, b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: cryabbprovided by ZNC
Official Full Name: crystallin, alpha B, bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040718-419
See related: Ensembl:ENSDARG00000101380 AllianceGenome:ZFIN:ZDB-GENE-040718-419
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: cryab2; fe37f08; zgc:91937; wu:fe37f08
Summary: Enables unfolded protein binding activity. Acts upstream of or within several processes, including heart contraction; myofibril assembly; and skeletal muscle tissue development. Is expressed in several structures, including brain; heart; lens; liver; and otic vesicle. Human ortholog(s) of this gene implicated in cataract 16 multiple types; dilated cardiomyopathy 1II; fatal infantile hypertonic myofibrillar myopathy; and myofibrillar myopathy 2. Orthologous to human CRYAB (crystallin alpha B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 5

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (57641116..57650564)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (56971363..56975676)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

alphaB-crystallin has a role in stress tolerance of the heart presumably through the proteostasis network; it also has a critical role through chaperone activity in the maintenance of lens transparency
Title: Loss of αB-crystallin function in zebrafish reveals critical roles in the development of the lens and stress resistance of the heart.
alphaB-crystallin (HSPB5) is expressed during development.
Title: Genome-wide analysis and expression profiling of the small heat shock proteins in zebrafish.

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables structural constituent of eye lens	IEA Inferred from Electronic Annotation more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within locomotory behavior	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within myofibril assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within skeletal muscle tissue development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: alpha-crystallin B chain; crystallin, alpha B, b

Names: alphaB2-crystallin; crystallin alphaB-b; crystallin, alpha B2; hspb5b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001002670.2 → NP_001002670.1 crystallin, alpha B, b

See identical proteins and their annotated locations for NP_001002670.1

Status: PROVISIONAL

Source sequence(s)

DQ113417

UniProtKB/TrEMBL

A0A2R8Q4Q6, B2GNH8, Q6DG35

Related

ENSDARP00000129989.1, ENSDART00000171309.2

Conserved Domains (3) summary

cd06478
Location:56 → 137

ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...

COG0071
Location:56 → 150

IbpA; Molecular chaperone IbpA, HSP20 family [Posttranslational modification, protein turnover, chaperones]

pfam00525
Location:1 → 47

Crystallin; Alpha crystallin A chain, N terminal

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

57641116..57650564

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_021476081.1 → XP_021331756.1 alpha-crystallin B chain isoform X1

UniProtKB/TrEMBL

A0A8M9Q8E3

Related

ENSDARP00000132828.1, ENSDART00000164742.2

Conserved Domains (2) summary

cd06478
Location:56 → 137

ACD_HspB4-5-6; Alpha-crystallin domain found in alphaA-crystallin (HspB4), alphaB-crystallin (HspB5), and the small heat shock protein (sHsp) HspB6, also known as Hsp20. sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, ...

pfam00525
Location:1 → 48

Crystallin; Alpha crystallin A chain, N terminal