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CG1774 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43722, updated on 10-May-2024

Summary

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Official Symbol
CG1774provided by FlyBase
Primary source
FLYBASE:FBgn0039856
Locus tag
Dmel_CG1774
See related
AllianceGenome:FB:FBgn0039856
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG1774
Summary
Predicted to enable acyl-CoA hydrolase activity. Predicted to be involved in acyl-CoA metabolic process. Predicted to be active in mitochondrion. Is expressed in adult head and organism. Orthologous to human ACOT9 (acyl-CoA thioesterase 9). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See CG1774 in Genome Data Viewer
Location:
100C7-100C7; 3-102 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (31592803..31594719)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (27418525..27420441)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45190 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Ribosomal protein L6 Neighboring gene Cyclin G Neighboring gene Medea

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
  2. The Toll pathway underlies host sexual dimorphism in resistance to both Gram-negative and Gram-positive bacteria in mated Drosophila. Duneau DF, et al. BMC Biol, 2017 Dec 21. PMID 29268741, Free PMC Article
  3. Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body. Juhász G, et al. Cell Death Differ, 2007 Jun. PMID 17363962, Free PMC Article
  4. Flexible origin of hydrocarbon/pheromone precursors in Drosophila melanogaster. Wicker-Thomas C, et al. J Lipid Res, 2015 Nov. PMID 26353752, Free PMC Article
  5. Nutrient control of gene expression in Drosophila: microarray analysis of starvation and sugar-dependent response. Zinke I, et al. EMBO J, 2002 Nov 15. PMID 12426388, Free PMC Article

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables fatty acyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acyl-CoA metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG1774-PA
CG1774-PB
NP_001287623.1
NP_651875.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    31592803..31594719
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143618.3 → NP_651875.1  uncharacterized protein Dmel_CG1774, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651875.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9W4
    Related
    FBpp0085159
    Conserved Domains (1) summary
    cd03442
    Location:107 → 241
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

  2. NM_001300694.1 → NP_001287623.1  uncharacterized protein Dmel_CG1774, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287623.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9V9W4
    Conserved Domains (1) summary
    cd03442
    Location:107 → 241
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9V9W4 Q9V9W4

Gene LinkOut

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