Acf ATP-dependent chromatin assembly factor large subunit [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Acfprovided by FlyBase
Official Full Name: ATP-dependent chromatin assembly factor large subunitprovided by FlyBase
Primary source: FLYBASE:FBgn0027620
Locus tag: Dmel_CG1966
See related: AllianceGenome:FB:FBgn0027620
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 175K protein; ACF; Acf-1; ACF/CHRAC; acf1; Acf1; ACF1; CAF; CG1966; CHRAC; CHRAC-175; dACF; dAcf1; dCHRAC; Dmel\CG1966; p170; p170/p185; p175
Summary: Enables ATPase activator activity and DNA binding activity. Involved in several processes, including nucleosome organization; regulation of ATPase activity; and regulation of gene expression. Located in nucleus. Part of ACF complex and CHRAC. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; endoderm anlage; extended germ band embryo; and female-specific anatomical entity. Orthologous to human BAZ1A (bromodomain adjacent to zinc finger domain 1A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (31793981..31799799)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (27619703..27625521)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

ACF1 has a role in nucleosome remodeling during Drosophila oogenesis
Title: A role for tuned levels of nucleosome remodeler subunit ACF1 during Drosophila oogenesis.
Altering the levels of ACF1 leads to global and variegated deviations from normal chromatin organisation with pleiotropic defects.
Title: Developmental role for ACF1-containing nucleosome remodellers in chromatin organisation.
The chromatin remodeler Acf1 directly represses Wg transcriptional targets.
Title: The chromatin remodelers ISWI and ACF1 directly repress Wingless transcriptional targets.
ACF1 facilitates HP1 binding to chromatin methylated at lysine 9 within the H3 N terminus (H3K9).
Title: HP1 binding to chromatin methylated at H3K9 is enhanced by auxiliary factors.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables ATPase regulator activity	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in DNA replication-dependent chromatin assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin organization	IDA Inferred from Direct Assay more info	PubMed
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nervous system development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleosome organization	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of DNA replication	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heterochromatin formation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of ACF complex	IDA Inferred from Direct Assay more info	PubMed
part_of ACF complex	IPI Inferred from Physical Interaction more info	PubMed
part_of CHRAC	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nuclear chromosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

Names: ATP-utilizing chromatin assembly and remodeling factor; Acf-PA; CG1966-PA; chromatin accessibility complex

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