PlexA Plexin A [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: PlexAprovided by FlyBase
Official Full Name: Plexin Aprovided by FlyBase
Primary source: FLYBASE:FBgn0025741
Locus tag: Dmel_CG11081
See related: AllianceGenome:FB:FBgn0025741
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: BcDNA:GM05237; CG11081; D-Plex A; Dmel\CG11081; DPlexA; lincRNA.927; plex; plex A; Plex1; plexA; Plexa; PlexA1; PlexinA
Summary: Enables 14-3-3 protein binding activity; enzyme activator activity; and heparin binding activity. Involved in several processes, including axon guidance; positive regulation of guanylate cyclase activity; and semaphorin-plexin signaling pathway involved in regulation of photoreceptor cell axon guidance. Predicted to be part of semaphorin receptor complex. Predicted to be integral component of plasma membrane. Is expressed in several structures, including adult ventral nerve cord; eye photoreceptor cell; large field neuron of the central complex; myoblast; and protocerebral bridge. Orthologous to several human genes including PLXNA2 (plexin A2); PLXNA3 (plexin A3); and PLXNA4 (plexin A4). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 102F5-102F6; 4-0 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	4	NC_004353.4 (1009895..1027101, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	4	NC_004353.3 (1030521..1047727, complement)

Chromosome 4 - NC_004353.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sema-5c antagonizes the activity of Lar, another transmembrane guidance cue that operates along leading-trailing cell-cell interfaces in this tissue, via a mechanism that appears to be independent of Plexin A.
Title: Planar-Polarized Semaphorin-5c and Plexin A Promote the Collective Migration of Epithelial Cells in Drosophila.
plexins function in epithelial wound healing in diverse taxa.
Title: Plexins function in epithelial repair in both Drosophila and zebrafish.
The transmembrane proteins semaphorin-1a (Sema-1a) and plexin A function together to regulate ellipsoid body laminated ring (R) neuron axon lamination.
Title: The laminar organization of the Drosophila ellipsoid body is semaphorin-dependent and prevents the formation of ectopic synaptic connections.
deleting the RasGAP domain abolished the ability of PlexA to rescue the PlexA axon guidance phenotypes
Title: The axon guidance function of Rap1 small GTPase is independent of PlexA RasGAP activity in Drosophila.
PlexA regulates Gyc76C catalytic activity in vitro, and each distinct Gyc76C protein domain is crucial for regulating Gyc76C activity in vitro and motor axon guidance in vivo.
Title: Function of the Drosophila receptor guanylyl cyclase Gyc76C in PlexA-mediated motor axon guidance.
PlexinA functions to suppress excessive axonal branches and synapses and PlexinB facilitates axonal growth.
Title: Opposing roles of PlexinA and PlexinB in axonal branch and varicosity formation.
The data of this study proposed that PlexA regulates Semala reverse signaling in the Drosophila visual system.
Title: Plexin a-semaphorin-1a reverse signaling regulates photoreceptor axon guidance in Drosophila.
MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
Title: MICALs, a family of conserved flavoprotein oxidoreductases, function in plexin-mediated axonal repulsion.
Semaphorin 2a secreted by oenocytes signals through plexin B and plexin A to guide sensory axons in the Drosophila embryo
Title: Semaphorin 2a secreted by oenocytes signals through plexin B and plexin A to guide sensory axons in the Drosophila embryo.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

mobile_element

Loc: c1011506-1010988 mobile_element_type = transposon:INE-1{}3354
Loc: c1014084-1013961 mobile_element_type = transposon:HB{}3909
Loc: c1020618-1020299 mobile_element_type = transposon:INE-1{}3357
Loc: c1021022-1020703 mobile_element_type = transposon:INE-1{}5438
Loc: c1021333-1021156 mobile_element_type = transposon:INE-1{}5436

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables 14-3-3 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables GTPase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables guanylate cyclase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables heparin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables semaphorin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables semaphorin receptor activity	IEA Inferred from Electronic Annotation more info
enables semaphorin receptor activity	TAS Traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
involved_in Ras protein signal transduction	IDA Inferred from Direct Assay more info	PubMed
involved_in axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in axon midline choice point recognition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in motor neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of cell adhesion	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of axonogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of GTPase activity	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell migration	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cell shape	IBA Inferred from Biological aspect of Ancestor more info
involved_in semaphorin-plexin signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in semaphorin-plexin signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron axon guidance	IBA Inferred from Biological aspect of Ancestor more info
involved_in sensory neuron axon guidance	IGI Inferred from Genetic Interaction more info	PubMed
involved_in sensory neuron axon guidance	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISM Inferred from Sequence Model more info	PubMed
part_of semaphorin receptor complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: plexin A

Names: CG11081-PA; CG11081-PB; CG11081-PC; CG11081-PF; PlexA-PA; PlexA-PB; PlexA-PC; PlexA-PF; PlexinA; plexin; plexin A1; plexin-A

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_004353.4 Reference assembly

Range

1009895..1027101 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001258499.2 → NP_001245428.1 plexin A, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001245428.1

Status: REVIEWED

UniProtKB/TrEMBL

H9XVP3, O96681

Conserved Domains (7) summary

cd11236
Location:75 → 520

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

cd00603
Location:1196 → 1255

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:978 → 1063

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:885 → 977

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:522 → 574

PSI; Plexin repeat

pfam08337
Location:1353 → 1899

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:1078 → 1177

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_166804.4 → NP_726627.1 plexin A, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726627.1

Status: REVIEWED

UniProtKB/TrEMBL

G7H847, Q0KIF1

Related

FBpp0088289

Conserved Domains (7) summary

cd00603
Location:756 → 815

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:538 → 623

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:445 → 537

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:390 → 443

PSI; Plexin repeat

pfam08337
Location:913 → 1476

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:638 → 737

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:5 → 116

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins
NM_079898.3 → NP_524637.2 plexin A, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524637.2

Status: REVIEWED

UniProtKB/TrEMBL

O96681, Q9V491

Related

FBpp0088287

Conserved Domains (7) summary

cd11236
Location:75 → 520

Sema_plexin_like; The Sema domain, a protein interacting module, of Plexins and MET-like receptor tyrosine kinases

cd00603
Location:1196 → 1255

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:978 → 1063

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:885 → 977

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:522 → 574

PSI; Plexin repeat

pfam08337
Location:1353 → 1916

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:1078 → 1177

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...
NM_166805.4 → NP_726628.1 plexin A, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726628.1

Status: REVIEWED

UniProtKB/TrEMBL

G7H847, Q0KIF1

Related

FBpp0088288

Conserved Domains (7) summary

cd00603
Location:756 → 815

IPT_PCSR; IPT domain of Plexins and Cell Surface Receptors (PCSR) and related proteins . This subgroup contains IPT domains of plexins, receptors, like the plasminogen-related growth factor receptors, the hepatocyte growth factor-scatter factors, and the ...

cd01179
Location:538 → 623

IPT_plexin_repeat2; Second repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

cd01180
Location:445 → 537

IPT_plexin_repeat1; First repeat of the IPT domain of Plexins and Cell Surface Receptors (PCSR) . Plexins are involved in the regulation of cell proliferation and of cellular adhesion and repulsion receptors. In general, there are three copies of the IPT domain present ...

pfam01437
Location:390 → 443

PSI; Plexin repeat

pfam08337
Location:913 → 1476

Plexin_cytopl; Plexin cytoplasmic RasGAP domain

cl15674
Location:638 → 737

IPT; Immunoglobulin-like fold, Plexins, Transcription factors (IPT). IPTs are also known as Transcription factor ImmunoGlobin (TIG) domains. They are present in intracellular transcription factors, cell surface receptors (such as plexins and scatter factor ...

cl15693
Location:5 → 116

Sema; The Sema domain, a protein interacting module, of semaphorins and plexins