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Ret Ret oncogene [ Drosophila melanogaster (fruit fly) ]

Gene ID: 43875, updated on 19-Oct-2021

Summary

Official Symbol
Retprovided by FlyBase
Official Full Name
Ret oncogeneprovided by FlyBase
Primary source
FLYBASE:FBgn0011829
Locus tag
Dmel_CG14396
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG1061; CG14396; D-ret; Dmel\CG14396; DmHD-59; DmRet; dret; dRet; dRET; Dret; DRet; DRET; HD-59; MEN2; ret; RET; Reto
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Genomic context

See Ret in Genome Data Viewer
Location:
39B1-39B1; 2-54 cM
Exon count:
7
Annotation release Status Assembly Chr Location
Release 6.32 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (21182446..21198762, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (21182446..21198762, complement)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA : PsiU2-38.40.42 Neighboring gene burgundy Neighboring gene antisense RNA:CR44911 Neighboring gene Minichromosome maintenance 10 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables calcium ion binding ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables integrin binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transmembrane receptor protein tyrosine kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Process Evidence Code Pubs
involved_in actin filament organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in multicellular organism development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in positive regulation of cell-matrix adhesion IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 
involved_in protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in regulation of dendrite development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cell surface IDA
Inferred from Direct Assay
more info
PubMed 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in integral component of plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in integral component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
located_in plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
part_of receptor complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
Ret oncogene
Names
CG14396-PA
CG14396-PB
CG14396-PC
Ret-PA
Ret-PB
Ret-PC
dret
NP_477044.1
NP_724315.1
NP_724316.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    21182446..21198762 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_057696.4NP_477044.1  Ret oncogene, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_477044.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT06
    Related
    FBpp0081023, FBtr0081495
    Conserved Domains (2) summary
    smart00219
    Location:7711042
    TyrKc; Tyrosine kinase, catalytic domain
    cl21453
    Location:7701049
    PKc_like; Protein Kinases, catalytic domain
  2. NM_165358.2NP_724315.1  Ret oncogene, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724315.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT06
    Related
    FBpp0081022, FBtr0081494
    Conserved Domains (2) summary
    smart00219
    Location:7711042
    TyrKc; Tyrosine kinase, catalytic domain
    cl21453
    Location:7701049
    PKc_like; Protein Kinases, catalytic domain
  3. NM_165359.2NP_724316.1  Ret oncogene, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_724316.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KT06
    Related
    FBpp0081021, FBtr0081493
    Conserved Domains (2) summary
    smart00219
    Location:7711042
    TyrKc; Tyrosine kinase, catalytic domain
    cl21453
    Location:7701049
    PKc_like; Protein Kinases, catalytic domain
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