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Fad2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44006, updated on 4-Apr-2024

Summary

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Official Symbol
Fad2provided by FlyBase
Primary source
FLYBASE:FBgn0029172
Locus tag
Dmel_CG7923
See related
AllianceGenome:FB:FBgn0029172
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7923; desatF; DesatF; desatF-alpha; Dmel CPVD; Dmel\CG7923; dsat-F; fad; fad2
Summary
Predicted to enable iron ion binding activity and stearoyl-CoA 9-desaturase activity. Involved in courtship behavior and pheromone metabolic process. Predicted to be active in endoplasmic reticulum membrane. Is expressed in adult heart; adult oenocyte; and organism. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 79. Orthologous to human SCD5 (stearoyl-CoA desaturase 5). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Fad2 in Genome Data Viewer
Location:
68A1-68A1; 3-34 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (11023535..11024846)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (11016635..11017946)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR45745 Neighboring gene klumpfuss Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Altered pheromone biosynthesis is associated with sex-specific changes in life span and behavior in Drosophila melanogaster. Joseph NM, et al. Mech Ageing Dev, 2018 Dec. PMID 30312624
  2. Identification of quantitative trait loci function through analysis of multiple cuticular hydrocarbons differing between Drosophila simulans and Drosophila sechellia females. Gleason JM, et al. Heredity (Edinb), 2009 Nov. PMID 19654611
  3. Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila. Legendre A, et al. Insect Biochem Mol Biol, 2008 Feb. PMID 18207084
  4. Contribution of oenocytes and pheromones to courtship behaviour in Drosophila. Wicker-Thomas C, et al. BMC Biochem, 2009 Aug 11. PMID 19671131, Free PMC Article
  5. A model-based analysis of chemical and temporal patterns of cuticular hydrocarbons in male Drosophila melanogaster. Kent C, et al. PLoS One, 2007 Sep 26. PMID 17896002, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. desatF is involved in the synthesis of 7,11-dienes; D. melanogaster/D. simulans hybrids with a chromosomal deletion of the gene had no dienes and received normal courtship from D. simulans males
    Title: Evolution of a desaturase involved in female pheromonal cuticular hydrocarbon biosynthesis and courtship behavior in Drosophila.
  2. desatF is a crucial enzyme for female pheromone biosynthesis and courtship behaviour in D. melanogaster.
    Title: A female-specific desaturase gene responsible for diene hydrocarbon biosynthesis and courtship behaviour in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables iron ion binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water IEA
Inferred from Electronic Annotation
more info
  
enables stearoyl-CoA 9-desaturase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables stearoyl-CoA 9-desaturase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in pheromone metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Fad2
Names
CG7923-PA
Fad2-PA
desaturase-F
NP_651966.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    11023535..11024846
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143709.3 → NP_651966.2  Fad2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_651966.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    C4IY13, Q9VTD4
    Related
    FBpp0075926
    Conserved Domains (1) summary
    cd03505
    Location:68 → 309
    Delta9-FADS-like; The Delta9 Fatty Acid Desaturase (Delta9-FADS)-like CD includes the delta-9 and delta-11 acyl CoA desaturases found in various eukaryotes including vertebrates, insects, higher plants, and fungi. The delta-9 acyl-lipid desaturases are found in a wide ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NFT2 Q9NFT2
Q9VTD4 Q9VTD4

Gene LinkOut

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