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sbb scribbler [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44027, updated on 10-May-2024

Summary

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Official Symbol
sbbprovided by FlyBase
Official Full Name
scribblerprovided by FlyBase
Primary source
FLYBASE:FBgn0285917
Locus tag
Dmel_CG5580
See related
AllianceGenome:FB:FBgn0285917
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
bks; Bks; Brakeless; CG5580; disc6; Dmel\CG5580; GM04742; Group IIa; l(2)04440; mtv; Mtv; plt; Sbb; SBb; sbb/mtv
Summary
Enables transcription corepressor activity. Involved in several processes, including axonogenesis; regulation of imaginal disc growth; and wing disc development. Located in nucleus. Is expressed in several structures, including embryonic/larval nervous system; extended germ band embryo; imaginal disc; presumptive embryonic/larval system; and testis. Orthologous to human ZNF608 (zinc finger protein 608) and ZNF609 (zinc finger protein 609). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See sbb in Genome Data Viewer
Location:
55C2-55C4; 2-85 cM
Exon count:
13
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (18278198..18357296, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (14165703..14244801, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene long non-coding RNA:CR44421 Neighboring gene presenilin enhancer Neighboring gene Otefin Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Transport and Golgi organization 8 Neighboring gene long non-coding RNA:CR42736 Neighboring gene Bomanin Tailed 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Serotonergic neuronal death and concomitant serotonin deficiency curb copulation ability of Drosophila platonic mutants. Yilmazer YB, et al. Nat Commun, 2016 Dec 13. PMID 27958269, Free PMC Article
  2. Alteration of wing size through over-expression of scribbler isoforms. LaJeuensse D. Fly (Austin), 2010 Oct-Dec. PMID 20798603
  3. Turning behavior in Drosophila larvae: a role for the small scribbler transcript. Suster ML, et al. Genes Brain Behav, 2004 Oct. PMID 15344921
  4. Abnormal turning behavior in Drosophila larvae. Identification and molecular analysis of scribbler (sbb). Yang P, et al. Genetics, 2000 Jul. PMID 10880478, Free PMC Article
  5. Construction of transgenic Drosophila by using the site-specific integrase from phage phiC31. Groth AC, et al. Genetics, 2004 Apr. PMID 15126397, Free PMC Article

See all (126) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. data provide support for a Brakeless activator function that regulates transcription by interacting with Med19
    Title: The Brakeless co-regulator can directly activate and repress transcription in early Drosophila embryos.
  2. Sbb is associated with wing size.
    Title: Alteration of wing size through over-expression of scribbler isoforms.
  3. Scribble is part of the Stbm/Vang PCP complex and further suggest that it might act as an effector of Stbm/Vang during PCP establishment.
    Title: The apical/basal-polarity determinant Scribble cooperates with the PCP core factor Stbm/Vang and functions as one of its effectors.
  4. Brakeless is recruited to the Kr and kni cis-regulatory DNA modules, and represses transcription when tethered to DNA.
    Title: Drosophila brakeless interacts with atrophin and is required for tailless-mediated transcriptional repression in early embryos.
  5. both LRR and PDZ domains are important for the proper localization and function of Scribble in neuroblasts
    Title: Scribble protein domain mapping reveals a multistep localization mechanism and domains necessary for establishing cortical polarity.
  6. The neoplastic tumor suppressor gene scribble, via the activity of the LRR, governs proliferation primarily by regulating apicobasal polarity.
    Title: Domains controlling cell polarity and proliferation in the Drosophila tumor suppressor Scribble.
  7. Studies focused on the smaller of the two scribbler transcripts and show that its pan-neural expression during early larval life, but not in later larval life, restores wild type turning behavior.
    Title: Turning behavior in Drosophila larvae: a role for the small scribbler transcript.
  8. The cytoarchitectural suppressor gene scribble interacts with cell adhesion, signaling, cytoskeletal, and chromatin remodeling genes to negatively regulate cyclin E or S-phase entry.
    Title: A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.
  9. mutations in Atro and Sbb have similar phenotypes, including upregulation of the same genes in imaginal discs, which suggests that Sbb cooperates with Atro to provide repressive activity
    Title: Genetic interactions among scribbler, Atrophin and groucho in Drosophila uncover links in transcriptional repression.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables transcription corepressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in axon guidance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon target recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in imaginal disc-derived wing morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval locomotory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in larval locomotory behavior TAS
Traceable Author Statement
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of imaginal disc growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in wing disc dorsal/ventral pattern formation IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
scribbler
Names
CG5580-PC
CG5580-PD
CG5580-PE
CG5580-PF
CG5580-PG
CG5580-PH
CG5580-PJ
brakeless
master of thickveins
mother of thick-vein
platonic
sbb-PC
sbb-PD
sbb-PE
sbb-PF
sbb-PG
sbb-PH
sbb-PJ

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    18278198..18357296 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001169720.2 → NP_001163191.1  scribbler, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163191.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGL0, Q9GRA9
    Conserved Domains (1) summary
    PRK10856
    Location:1143 → 1245
    PRK10856; cytoskeletal protein RodZ; Provisional

  2. NM_001169718.3 → NP_001163189.1  scribbler, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163189.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB50, Q9GRA9, Q9N693
    Conserved Domains (1) summary
    PRK10856
    Location:1133 → 1235
    PRK10856; cytoskeletal protein RodZ; Provisional

  3. NM_001274145.1 → NP_001261074.1  scribbler, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261074.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A0B4KEU2, Q9GRA9
    Conserved Domains (1) summary
    PRK10856
    Location:1143 → 1245
    PRK10856; cytoskeletal protein RodZ; Provisional

  4. NM_079939.5 → NP_524678.3  scribbler, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524678.3

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB50, Q9GRA9, Q9N693
    Conserved Domains (1) summary
    PRK10856
    Location:1133 → 1235
    PRK10856; cytoskeletal protein RodZ; Provisional

  5. NM_206161.3 → NP_995883.1  scribbler, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995883.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A1ZB51, Q9NHQ0

  6. NM_001169719.2 → NP_001163190.1  scribbler, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163190.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NBL3, Q9NBW0

  7. NM_206162.4 → NP_995884.1  scribbler, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_995884.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NBL3, Q9NBW0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A0B4KEU2 A0A0B4KEU2
A1ZB51 A1ZB51
E1JGL0 E1JGL0
Q8SX80 Q8SX80
Q8T9H1 Q8T9H1
Q9GRA9 Q9GRA9
Q9N693 Q9N693
Q9NBL3 Q9NBL3
Q9NBW0 Q9NBW0
Q9NGW5 Q9NGW5
Q9NHQ0 Q9NHQ0

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