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Mkrn1 Makorin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44131, updated on 10-May-2024

Summary

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Official Symbol
Mkrn1provided by FlyBase
Official Full Name
Makorin 1provided by FlyBase
Primary source
FLYBASE:FBgn0029152
Locus tag
Dmel_CG7184
See related
AllianceGenome:FB:FBgn0029152
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7184; Dmel\CG7184; mkrn1; MKRN1
Summary
Enables mRNA 3'-UTR binding activity. Involved in several processes, including positive regulation of insulin receptor signaling pathway; positive regulation of oogenesis; and positive regulation of oskar mRNA translation. Part of ribonucleoprotein complex. Is active in P granule. Is expressed in organism. Orthologous to human MKRN1 (makorin ring finger protein 1) and MKRN2 (makorin ring finger protein 2). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Mkrn1 in Genome Data Viewer
Location:
78D5-78D5; 3-47 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (21529959..21533713, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (21523059..21526813, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene antisense RNA:CR43877 Neighboring gene ACAT-related protein required for viability 1 Neighboring gene pickpocket 5 Neighboring gene Regulatory particle non-ATPase 10

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The ancient source of a distinct gene family encoding proteins featuring RING and C(3)H zinc-finger motifs with abundant expression in developing brain and nervous system. Gray TA, et al. Genomics, 2000 May 15. PMID 10843807
  2. Makorin 1 Regulates Developmental Timing in Drosophila. Tran HT, et al. Mol Cells, 2018 Dec 31. PMID 30396233, Free PMC Article
  3. Hyd ubiquitinates the NF-κB co-factor Akirin to operate an effective immune response in Drosophila. Cammarata-Mouchtouris A, et al. PLoS Pathog, 2020 Apr. PMID 32339205, Free PMC Article
  4. Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling. Jeong EB, et al. PLoS One, 2019. PMID 31009498, Free PMC Article
  5. Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation. Dold A, et al. PLoS Genet, 2020 Jan. PMID 31978041, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mkrn1 controls embryonic patterning and germ cell formation by specifically activating osk translation, most likely by competing with Bru1 to bind to osk 3' UTR.
    Title: Makorin 1 controls embryonic patterning by alleviating Bruno1-mediated repression of oskar translation.
  2. Data indicate that Drosophila Makorin RING finger protein 1 gene (Mkrn1) functions in the metabolic regulation of oogenesis.
    Title: Makorin 1 is required for Drosophila oogenesis by regulating insulin/Tor signaling.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin protein ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin protein ligase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables zinc ion binding ISM
Inferred from Sequence Model
more info
 PubMed 
Process Evidence Code Pubs
involved_in anterior/posterior axis specification, embryo IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of insulin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of oskar mRNA translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein polyubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein polyubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein ubiquitination IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in P granule IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in pole plasm IDA
Inferred from Direct Assay
more info
 PubMed 
part_of ribonucleoprotein complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
makorin 1
Names
CG7184-PA
CG7184-PB
CG7184-PC
Mkrn1-PA
Mkrn1-PB
Mkrn1-PC

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    21529959..21533713 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079965.4 → NP_524704.1  makorin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524704.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TM0, Q9TVX6, Q9VP20
    Related
    FBpp0078038
    Conserved Domains (2) summary
    smart00356
    Location:20 → 43
    ZnF_C3H1; zinc finger
    cd00162
    Location:213 → 267
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  2. NM_168922.3 → NP_730653.1  makorin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730653.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TM0, Q9TVX6, Q9VP20
    Related
    FBpp0078039
    Conserved Domains (2) summary
    smart00356
    Location:20 → 43
    ZnF_C3H1; zinc finger
    cd00162
    Location:213 → 267
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...

  3. NM_001259938.2 → NP_001246867.1  makorin 1, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246867.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95TM0, Q9TVX6, Q9VP20
    Conserved Domains (2) summary
    smart00356
    Location:20 → 43
    ZnF_C3H1; zinc finger
    cd00162
    Location:213 → 267
    RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9TVX6 Q9TVX6
Q9VP20 Q9VP20

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