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Hmgs HMG Coenzyme A synthase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 44154, updated on 4-Apr-2024

Summary

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Official Symbol
Hmgsprovided by FlyBase
Official Full Name
HMG Coenzyme A synthaseprovided by FlyBase
Primary source
FLYBASE:FBgn0010611
Locus tag
Dmel_CG4311
See related
AllianceGenome:FB:FBgn0010611
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG16796; CG4311; Dmel\CG4311; HMGS; l(2)06214; Ov25
Summary
Predicted to enable hydroxymethylglutaryl-CoA synthase activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Is expressed in several structures, including adult head; embryonic/larval dorsal trunk; and presumptive embryonic/larval system. Orthologous to human HMGCS1 (3-hydroxy-3-methylglutaryl-CoA synthase 1) and HMGCS2 (3-hydroxy-3-methylglutaryl-CoA synthase 2). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See Hmgs in Genome Data Viewer
Location:
53C1-53C1; 2-80 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16336090..16341242)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (12223595..12228747)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Vacuolar H[+] ATPase 44kD subunit Neighboring gene uncharacterized protein Neighboring gene Nucleoporin 62kD

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Glia fuel neurons with locally synthesized ketone bodies to sustain memory under starvation. Silva B, et al. Nat Metab, 2022 Feb. PMID 35177854, Free PMC Article
  2. MicroRNA miR-8 promotes cell growth of corpus allatum and juvenile hormone biosynthesis independent of insulin/IGF signaling in Drosophila melanogaster. Zhang J, et al. Insect Biochem Mol Biol, 2021 Sep. PMID 34182107
  3. CoA protects against the deleterious effects of caloric overload in Drosophila. Palanker Musselman L, et al. J Lipid Res, 2016 Mar. PMID 26805007, Free PMC Article
  4. Modes of metabolic compensation during mitochondrial disease using the Drosophila model of ATP6 dysfunction. Celotto AM, et al. PLoS One, 2011. PMID 21991365, Free PMC Article
  5. Regulation of SREBP processing and membrane lipid production by phospholipids in Drosophila. Dobrosotskaya IY, et al. Science, 2002 May 3. PMID 11988566

See all (47) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA synthase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in acetyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in acetyl-CoA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in farnesyl diphosphate biosynthetic process, mevalonate pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
HMG coenzyme A synthase
Names
CG4311-PA
CG4311-PB
CG4311-PC
CG4311-PD
CG4311-PE
CG4311-PF
HMG-CoA synthase
Hmgs-PA
Hmgs-PB
Hmgs-PC
Hmgs-PD
Hmgs-PE
Hmgs-PF
hydroxy-3-methylglutaryl-CoA synthase
NP_001286488.1
NP_524711.1
NP_725567.1
NP_725568.1
NP_725569.1
NP_725570.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16336090..16341242
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079972.4 → NP_524711.1  HMG coenzyme A synthase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524711.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Q9
    Related
    FBpp0086289
    Conserved Domains (3) summary
    TIGR01833
    Location:5 → 456
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:179 → 456
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:8 → 178
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

  2. NM_001299559.1 → NP_001286488.1  HMG coenzyme A synthase, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286488.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Q9
    Conserved Domains (3) summary
    TIGR01833
    Location:5 → 456
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:179 → 456
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:8 → 178
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

  3. NM_166167.3 → NP_725568.1  HMG coenzyme A synthase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725568.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Q9
    Related
    FBpp0086290
    Conserved Domains (3) summary
    TIGR01833
    Location:5 → 456
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:179 → 456
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:8 → 178
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

  4. NM_166166.3 → NP_725567.1  HMG coenzyme A synthase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725567.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Q9
    Related
    FBpp0086291
    Conserved Domains (3) summary
    TIGR01833
    Location:5 → 456
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:179 → 456
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:8 → 178
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

  5. NM_166168.3 → NP_725569.1  HMG coenzyme A synthase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725569.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Q9
    Related
    FBpp0086292
    Conserved Domains (3) summary
    TIGR01833
    Location:5 → 456
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:179 → 456
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:8 → 178
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...

  6. NM_166169.3 → NP_725570.1  HMG coenzyme A synthase, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_725570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7K4Q9
    Related
    FBpp0086293
    Conserved Domains (3) summary
    TIGR01833
    Location:5 → 456
    HMG-CoA-S_euk; 3-hydroxy-3-methylglutaryl-CoA-synthase, eukaryotic clade
    pfam08540
    Location:179 → 456
    HMG_CoA_synt_C; Hydroxymethylglutaryl-coenzyme A synthase C terminal
    cl09938
    Location:8 → 178
    cond_enzymes; Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7K4Q9 Q7K4Q9

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