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Arhgef15 Rho guanine nucleotide exchange factor 15 [ Mus musculus (house mouse) ]

Gene ID: 442801, updated on 21-Apr-2024

Summary

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Official Symbol
Arhgef15provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor 15provided by MGI
Primary source
MGI:MGI:3045246
See related
Ensembl:ENSMUSG00000052921 AllianceGenome:MGI:3045246
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E5; D130071N09; D530030K12Rik
Summary
Enables guanyl-nucleotide exchange factor activity. Involved in negative regulation of synapse maturation. Acts upstream of or within retina vasculature morphogenesis in camera-type eye. Located in dendrite. Is expressed in several structures, including adipose tissue; alimentary system; genitourinary system; hemolymphoid system gland; and respiratory system. Orthologous to human ARHGEF15 (Rho guanine nucleotide exchange factor 15). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in lung adult (RPKM 39.8), adrenal adult (RPKM 12.1) and 15 other tissues See more
Orthologs
human all
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Genomic context

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Location:
11 B3; 11 42.21 cM
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68819726..68847760, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68928900..68956934, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22608 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene predicted gene, 51902 Neighboring gene STARR-positive B cell enhancer ABC_E8415 Neighboring gene predicted gene, 32273 Neighboring gene STARR-positive B cell enhancer ABC_E2994 Neighboring gene STARR-positive B cell enhancer ABC_E11482 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture. Ding X, et al. Acta Neuropathol, 2023 May. PMID 36929019
  2. ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice. Wang YJ, et al. Reprod Biol, 2023 Mar. PMID 36603298
  3. A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth. Hamilton AM, et al. Mol Cell Neurosci, 2017 Apr. PMID 28185854, Free PMC Article
  4. Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice. Sell GL, et al. J Clin Invest, 2017 May 1. PMID 28346227, Free PMC Article
  5. Arhgef15 promotes retinal angiogenesis by mediating VEGF-induced Cdc42 activation and potentiating RhoJ inactivation in endothelial cells. Kusuhara S, et al. PLoS One, 2012. PMID 23029280, Free PMC Article

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture.
    Title: Mutations in ARHGEF15 cause autosomal dominant hereditary cerebral small vessel disease and osteoporotic fracture.
  2. ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice.
    Title: ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice.
  3. a substrate of PKCepsilon, Ephexin5, whose early-elevated expression in developing neurons may in part explain the mechanism by which PKCepsilon plays seemingly opposing roles that depend on neuronal maturity.
    Title: PKCε Inhibits Neuronal Dendritic Spine Development through Dual Phosphorylation of Ephexin5.
  4. pathological elevation of Ephexin5 expression critically drives Abeta-induced memory impairment
    Title: Reducing expression of synapse-restricting protein Ephexin5 ameliorates Alzheimer's-like impairment in mice.
  5. The data of this study support a model in which Ephexin5 serves a dual role in spinogenesis, acting both as a brake on overall spine outgrowth and as a necessary component in the site-specific formation of new spines
    Title: A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth.
  6. Study identified a RhoA guanine nucleotide exchange factor, Ephexin5, which negatively regulates excitatory synapse development until EphrinB binding to the EphB receptor triggers Ephexin5 phosphorylation, ubiquitination, and degradation.[Ephexin5]
    Title: EphB-mediated degradation of the RhoA GEF Ephexin5 relieves a developmental brake on excitatory synapse formation.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Clone Names

  • MGC102247, MGC144141, MGC144142

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
  
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in activation of GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of stress fiber assembly ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of catalytic activity ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of postsynapse assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of postsynapse assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina vasculature morphogenesis in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
  
located_in dendrite IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in glutamatergic synapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
rho guanine nucleotide exchange factor 15
Names
Rho guanine nucleotide exchange factor (GEF) 15
ephexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364772.2 → NP_001351701.1  rho guanine nucleotide exchange factor 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL603662
    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  2. NM_177566.5 → NP_808234.2  rho guanine nucleotide exchange factor 15 isoform 1

    See identical proteins and their annotated locations for NP_808234.2

    Status: VALIDATED

    Source sequence(s)
    AL603662
    Consensus CDS
    CCDS24873.1
    UniProtKB/Swiss-Prot
    Q14B44, Q5FWH6, Q69ZV7
    Related
    ENSMUSP00000067684.7, ENSMUST00000065040.13
    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68819726..68847760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249118.2 → XP_011247420.1  rho guanine nucleotide exchange factor 15 isoform X7

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  2. XM_011249122.2 → XP_011247424.1  rho guanine nucleotide exchange factor 15 isoform X12

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  3. XM_011249112.1 → XP_011247414.1  rho guanine nucleotide exchange factor 15 isoform X1

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  4. XM_011249117.1 → XP_011247419.1  rho guanine nucleotide exchange factor 15 isoform X6

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  5. XM_011249119.1 → XP_011247421.1  rho guanine nucleotide exchange factor 15 isoform X8

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  6. XM_030246113.1 → XP_030101973.1  rho guanine nucleotide exchange factor 15 isoform X2

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  7. XM_011249114.1 → XP_011247416.1  rho guanine nucleotide exchange factor 15 isoform X3

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  8. XM_011249121.1 → XP_011247423.1  rho guanine nucleotide exchange factor 15 isoform X10

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  9. XM_030246115.1 → XP_030101975.1  rho guanine nucleotide exchange factor 15 isoform X13

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630 → 691
    PH-like; Pleckstrin homology-like domain

  10. XM_030246114.1 → XP_030101974.1  rho guanine nucleotide exchange factor 15 isoform X11

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630 → 691
    PH-like; Pleckstrin homology-like domain

  11. XM_017314643.1 → XP_017170132.1  rho guanine nucleotide exchange factor 15 isoform X11

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630 → 691
    PH-like; Pleckstrin homology-like domain

  12. XM_006533664.2 → XP_006533727.1  rho guanine nucleotide exchange factor 15 isoform X5

    See identical proteins and their annotated locations for XP_006533727.1

    UniProtKB/Swiss-Prot
    Q14B44, Q5FWH6, Q69ZV7
    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  13. XM_011249120.1 → XP_011247422.1  rho guanine nucleotide exchange factor 15 isoform X9

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  14. XM_011249116.1 → XP_011247418.1  rho guanine nucleotide exchange factor 15 isoform X4

    See identical proteins and their annotated locations for XP_011247418.1

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  15. XM_011249115.1 → XP_011247417.1  rho guanine nucleotide exchange factor 15 isoform X4

    See identical proteins and their annotated locations for XP_011247417.1

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630 → 750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

  16. XM_006533669.2 → XP_006533732.1  rho guanine nucleotide exchange factor 15 isoform X14

    See identical proteins and their annotated locations for XP_006533732.1

    Conserved Domains (2) summary
    smart00325
    Location:430 → 606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630 → 691
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_879714.4 RNA Sequence

  2. XR_001780023.1 RNA Sequence

  3. XR_388488.2 RNA Sequence

  4. XR_003949471.1 RNA Sequence

  5. XR_388487.3 RNA Sequence

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q5FWH6.1 GenPept UniProtKB/Swiss-Prot:Q5FWH6

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