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Arhgef15 Rho guanine nucleotide exchange factor (GEF) 15 [ Mus musculus (house mouse) ]

Gene ID: 442801, updated on 23-Jun-2021

Summary

Official Symbol
Arhgef15provided by MGI
Official Full Name
Rho guanine nucleotide exchange factor (GEF) 15provided by MGI
Primary source
MGI:MGI:3045246
See related
Ensembl:ENSMUSG00000052921
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
E5; D130071N09; D530030K12Rik
Expression
Broad expression in lung adult (RPKM 39.8), adrenal adult (RPKM 12.1) and 15 other tissues See more
Orthologs
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Genomic context

See Arhgef15 in Genome Data Viewer
Location:
11; 11 B3
Exon count:
20
Annotation release Status Assembly Chr Location
109 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (68819726..68847760, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (68928900..68956934, complement)
Build 37.2 previous assembly MGSCv37 (GCF_000001635.18) 11 NC_000077.5 (68756656..68770360, complement)

Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 22608 Neighboring gene outer dense fiber of sperm tails 4 Neighboring gene predicted gene, 51902 Neighboring gene predicted gene, 32273 Neighboring gene solute carrier family 25, member 35 Neighboring gene RAN guanine nucleotide release factor

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Clone Names

  • MGC102247, MGC144141, MGC144142

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables GTPase activator activity IEA
Inferred from Electronic Annotation
more info
 
enables guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
enables guanyl-nucleotide exchange factor activity ISO
Inferred from Sequence Orthology
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 
located_in cytoplasm ISO
Inferred from Sequence Orthology
more info
 
located_in dendrite IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
rho guanine nucleotide exchange factor 15
Names
ephexin-5

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001364772.1NP_001351701.1  rho guanine nucleotide exchange factor 15 isoform 2

    Status: VALIDATED

    Source sequence(s)
    BC089365, BC116343, BY132845
    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  2. NM_177566.4NP_808234.2  rho guanine nucleotide exchange factor 15 isoform 1

    See identical proteins and their annotated locations for NP_808234.2

    Status: VALIDATED

    Source sequence(s)
    BC089365, BY132845
    Consensus CDS
    CCDS24873.1
    UniProtKB/Swiss-Prot
    Q5FWH6
    Related
    ENSMUSP00000067684.7, ENSMUST00000065040.13
    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Mus musculus Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000077.7 Reference GRCm39 C57BL/6J

    Range
    68819726..68847760 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011249118.2XP_011247420.1  rho guanine nucleotide exchange factor 15 isoform X7

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  2. XM_011249122.2XP_011247424.1  rho guanine nucleotide exchange factor 15 isoform X12

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  3. XM_011249112.1XP_011247414.1  rho guanine nucleotide exchange factor 15 isoform X1

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  4. XM_011249117.1XP_011247419.1  rho guanine nucleotide exchange factor 15 isoform X6

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  5. XM_011249119.1XP_011247421.1  rho guanine nucleotide exchange factor 15 isoform X8

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  6. XM_030246113.1XP_030101973.1  rho guanine nucleotide exchange factor 15 isoform X2

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  7. XM_011249114.1XP_011247416.1  rho guanine nucleotide exchange factor 15 isoform X3

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  8. XM_011249121.1XP_011247423.1  rho guanine nucleotide exchange factor 15 isoform X10

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  9. XM_030246115.1XP_030101975.1  rho guanine nucleotide exchange factor 15 isoform X13

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630691
    PH-like; Pleckstrin homology-like domain
  10. XM_030246114.1XP_030101974.1  rho guanine nucleotide exchange factor 15 isoform X11

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630691
    PH-like; Pleckstrin homology-like domain
  11. XM_017314643.1XP_017170132.1  rho guanine nucleotide exchange factor 15 isoform X11

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630691
    PH-like; Pleckstrin homology-like domain
  12. XM_006533664.2XP_006533727.1  rho guanine nucleotide exchange factor 15 isoform X5

    See identical proteins and their annotated locations for XP_006533727.1

    UniProtKB/Swiss-Prot
    Q5FWH6
    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  13. XM_011249120.1XP_011247422.1  rho guanine nucleotide exchange factor 15 isoform X9

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  14. XM_011249116.1XP_011247418.1  rho guanine nucleotide exchange factor 15 isoform X4

    See identical proteins and their annotated locations for XP_011247418.1

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  15. XM_011249115.1XP_011247417.1  rho guanine nucleotide exchange factor 15 isoform X4

    See identical proteins and their annotated locations for XP_011247417.1

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cd01221
    Location:630750
    PH_ephexin; Ephexin Pleckstrin homology (PH) domain
  16. XM_006533669.2XP_006533732.1  rho guanine nucleotide exchange factor 15 isoform X14

    See identical proteins and their annotated locations for XP_006533732.1

    Conserved Domains (2) summary
    smart00325
    Location:430606
    RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases
    cl17171
    Location:630691
    PH-like; Pleckstrin homology-like domain

RNA

  1. XR_879714.4 RNA Sequence

  2. XR_001780023.1 RNA Sequence

  3. XR_388488.2 RNA Sequence

  4. XR_003949471.1 RNA Sequence

  5. XR_388487.3 RNA Sequence

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