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CLU clusterin [ Canis lupus familiaris (dog) ]

Gene ID: 442971, updated on 28-Sep-2021

Summary

Official Symbol
CLUprovided by VGNC
Official Full Name
clusterinprovided by VGNC
Primary source
VGNC:VGNC:39369
See related
EnsemblRapid:ENSCAFG00845010565
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as
GP80
Summary
This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Orthologs
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Genomic context

See CLU in Genome Data Viewer
Location:
chromosome: 25
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (30173217..30190014)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (30569577..30586344)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (30150889..30167668)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (30103442..30120185)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (29984486..30001273)
105 previous assembly CanFam3.1 (GCF_000002285.3) 25 NC_006607.3 (29982811..29999565)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC106557781 Neighboring gene scavenger receptor class A member 3 Neighboring gene 40S ribosomal protein S24-like Neighboring gene uncharacterized LOC119865942 Neighboring gene L-gulonolactone oxidase Neighboring gene epoxide hydrolase 2

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GO

Function Evidence Code Pubs
NOT enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables chaperone binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables misfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables ubiquitin protein ligase binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables unfolded protein binding ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
involved_in chaperone-mediated protein folding ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in immune complex clearance ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of amyloid fibril formation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of protein-containing complex assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of NF-kappaB transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of intrinsic apoptotic signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of proteasomal ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of receptor-mediated endocytosis IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in positive regulation of ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in protein stabilization ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell population proliferation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in response to misfolded protein ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in chromaffin granule IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with collagen-containing extracellular matrix ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
PubMed 
located_in extracellular space ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrial inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in mitochondrion ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear endoplasmic reticulum lumen ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in perinuclear region of cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
part_of spherical high-density lipoprotein particle ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
clusterin
Names
clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J)
glycoprotein 80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001003370.1NP_001003370.1  clusterin precursor

    See identical proteins and their annotated locations for NP_001003370.1

    Status: PROVISIONAL

    Source sequence(s)
    M55251
    UniProtKB/Swiss-Prot
    P25473
    Related
    ENSCAFP00845014566.1, ENSCAFT00845018653.1
    Conserved Domains (1) summary
    pfam01093
    Location:30441
    Clusterin

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    30173217..30190014
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    30103442..30120185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    29984486..30001273
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    30150889..30167668
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30569577..30586344
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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