CLU clusterin [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: CLUprovided by VGNC
Official Full Name: clusterinprovided by VGNC
Primary source: VGNC:VGNC:39369
See related: Ensembl:ENSCAFG00845010565
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: GP80
Summary: This gene encodes a protein that is similar to the human clusterin protein, a secreted chaperone that can also be found in the cell cytosol under certain stress conditions. The human protein has been suggested to be involved in several basic biological events such as cell death, tumor progression, and neurodegenerative disorders. [provided by RefSeq, May 2011]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	25	NC_051829.1 (30173217..30190014)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	25	NC_006607.4 (30569577..30586344)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	25	NC_049246.1 (30150889..30167668)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	25	NC_049285.1 (30103442..30120185)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	25	NC_049766.1 (29984486..30001273)

Chromosome 25 - NC_051829.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Real time RT-PCR and western blotting analysis indicated there was a greater abundance of clusterin in cryptorchid dog testes. Furthermore, clusterin was detected in extracellular regions of cryptorchid dog testes.
Title: Germ cell-specific apoptosis by extracellular clusterin in cryptorchid dog testes.
Clusterin may potentially serve as a marker for chronic spinal cord disease in the dog.
Title: The chaperone protein clusterin may serve as a cerebrospinal fluid biomarker for chronic spinal cord disorders in the dog.
The chaperone clusterin mediates systemic clearance of extracellular misfolded proteins
Title: Clusterin facilitates in vivo clearance of extracellular misfolded proteins.
The chaperone action of clusterin is important in quality control of extracellular protein folding
Title: Chapter 6: The chaperone action of Clusterin and its putative role in quality control of extracellular protein folding.
The extracellular chaperone clusterin appears in the cytosol during endoplasmic reticulum stress
Title: Stress-induced retrotranslocation of clusterin/ApoJ into the cytosol.
The chaperone action of clusterin targets prefibrillar species to inhibit amyloid formation
Title: The extracellular chaperone clusterin influences amyloid formation and toxicity by interacting with prefibrillar structures.
The chaperone action of clusterin is independent of ATP
Title: Clusterin is an ATP-independent chaperone with very broad substrate specificity that stabilizes stressed proteins in a folding-competent state.
The chaperone action of clusterin is like that of the small heat shock proteins
Title: Clusterin is a secreted mammalian chaperone.
Clusterin is an extracellular holdase-type chaperone
Title: Clusterin has chaperone-like activity similar to that of small heat shock proteins.
Clusterin expression may increase cardiac progenitor cell migration via increasing CXCR4 expression and SDF-1/chemokine receptor signaling in a PI3/Akt-dependent manner.
Title: Clusterin induces CXCR4 expression and migration of cardiac progenitor cells.

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General gene information

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General protein information

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Preferred Names: clusterin

Names: clusterin (complement lysis inhibitor, SP-40,40, sulfated glycoprotein 2, testosterone-repressed prostate message 2, apolipoprotein J); glycoprotein 80

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.