Format

Send to:

Choose Destination

CFTR CF transmembrane conductance regulator [ Ovis aries (sheep) ]

Gene ID: 443347, updated on 18-May-2019

Summary

Gene symbol
CFTR
Gene description
CF transmembrane conductance regulator
See related
Ensembl:ENSOARG00000018133
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs

Genomic context

See CFTR in Genome Data Viewer
Location:
chromosome: 4
Exon count:
27
Annotation release Status Assembly Chr Location
103 current Oar_rambouillet_v1.0 (GCF_002742125.1) 4 NC_040255.1 (57106498..57293281, complement)
102 previous assembly Oar_v4.0 (GCF_000298735.2) 4 NC_019461.2 (50644000..50864925, complement)

Chromosome 4 - NC_040255.1Genomic Context describing neighboring genes Neighboring gene transfer RNA cysteine (anticodon GCA) Neighboring gene 40S ribosomal protein S24-like Neighboring gene cortactin binding protein 2 Neighboring gene U6 spliceosomal RNA Neighboring gene ankyrin repeat, SAM and basic leucine zipper domain containing 1 Neighboring gene Wnt family member 2

Genomic regions, transcripts, and products

Expression

  • Project title: Sheep Tissue Atlas
  • Description: Sheep total RNA was extracted from embryonic and adult tissues
  • BioProject: PRJEB6169
  • Publication: PMID 24904168
  • Analysis date: Mon Jan 29 09:33:46 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • ABC transporters, organism-specific biosystem (from KEGG)
    ABC transporters, organism-specific biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • ABC transporters, conserved biosystem (from KEGG)
    ABC transporters, conserved biosystemThe ATP-binding cassette (ABC) transporters form one of the largest known protein families, and are widespread in bacteria, archaea, and eukaryotes. They couple ATP hydrolysis to active transport of ...
  • AMPK signaling pathway, organism-specific biosystem (from KEGG)
    AMPK signaling pathway, organism-specific biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • AMPK signaling pathway, conserved biosystem (from KEGG)
    AMPK signaling pathway, conserved biosystemAMP-activated protein kinase (AMPK) is a serine threonine kinase that is highly conserved through evolution. AMPK system acts as a sensor of cellular energy status. It is activated by increases in th...
  • Bile secretion, organism-specific biosystem (from KEGG)
    Bile secretion, organism-specific biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Bile secretion, conserved biosystem (from KEGG)
    Bile secretion, conserved biosystemBile is a vital secretion, essential for digestion and absorption of fats and fat-soluble vitamins in the small intestine. Moreover, bile is an important route of elimination for excess cholesterol a...
  • Gastric acid secretion, organism-specific biosystem (from KEGG)
    Gastric acid secretion, organism-specific biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Gastric acid secretion, conserved biosystem (from KEGG)
    Gastric acid secretion, conserved biosystemGastric acid is a key factor in normal upper gastrointestinal functions, including protein digestion and calcium and iron absorption, as well as providing some protection against bacterial infections...
  • Pancreatic secretion, organism-specific biosystem (from KEGG)
    Pancreatic secretion, organism-specific biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Pancreatic secretion, conserved biosystem (from KEGG)
    Pancreatic secretion, conserved biosystemThe pancreas performs both exocrine and endocrine functions. The exocrine pancreas consists of two parts, the acinar and duct cells. The primary functions of pancreatic acinar cells are to synthesiz...
  • Tight junction, organism-specific biosystem (from KEGG)
    Tight junction, organism-specific biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • Tight junction, conserved biosystem (from KEGG)
    Tight junction, conserved biosystemTight junctions (TJs) are essential for establishing a selectively permeable barrier to diffusion through the paracellular space between neighboring cells. TJs are composed of at least three types of...
  • cAMP signaling pathway, organism-specific biosystem (from KEGG)
    cAMP signaling pathway, organism-specific biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...
  • cAMP signaling pathway, conserved biosystem (from KEGG)
    cAMP signaling pathway, conserved biosystemcAMP is one of the most common and universal second messengers, and its formation is promoted by adenylyl cyclase (AC) activation after ligation of G protein-coupled receptors (GPCRs) by ligands incl...

General gene information

Markers

Homology

General protein information

Preferred Names
cystic fibrosis transmembrane conductance regulator
Names
ATP-binding cassette sub-family C member 7
ATP-binding cassette transporter sub-family C member 7
cAMP-dependent chloride channel
channel conductance-controlling ATPase
cystic fibrosis transmembrane conductance regulator, ATP-binding cassette (sub-family C, member 7)
NP_001009781.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009781.1NP_001009781.1  cystic fibrosis transmembrane conductance regulator

    See identical proteins and their annotated locations for NP_001009781.1

    Status: PROVISIONAL

    Source sequence(s)
    U20418
    UniProtKB/Swiss-Prot
    Q00555
    Related
    ENSOARP00000019473, ENSOART00000019744
    Conserved Domains (6) summary
    cd03291
    Location:389669
    ABCC_CFTR1; ATP-binding cassette domain of the cystic fibrosis transmembrane regulator, subfamily C
    TIGR01271
    Location:11469
    CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)
    pfam00664
    Location:9131147
    ABC_membrane; ABC transporter transmembrane region
    pfam14396
    Location:638849
    CFTR_R; Cystic fibrosis TM conductance regulator (CFTR), regulator domain
    cl00549
    Location:85306
    ABC_membrane; ABC transporter transmembrane region
    cl21455
    Location:12091469
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

RefSeqs of Annotated Genomes: Ovis aries Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Oar_rambouillet_v1.0 Primary Assembly

Genomic

  1. NC_040255.1 Reference Oar_rambouillet_v1.0 Primary Assembly

    Range
    57106498..57293281 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center