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ATP1A1 ATPase Na+/K+ transporting subunit alpha 1 [ Ovis aries (sheep) ]

Gene ID: 443381, updated on 5-Mar-2024

Summary

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Gene symbol
ATP1A1
Gene description
ATPase Na+/K+ transporting subunit alpha 1
See related
EnsemblRapid:ENSOARG00020000332
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Orthologs
human mouse all
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Genomic context

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See ATP1A1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
RS_2023_10 current ARS-UI_Ramb_v3.0 (GCF_016772045.2) 1 NC_056054.1 (93717246..93750077)

Chromosome 1 - NC_056054.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121817648 Neighboring gene uncharacterized LOC121817653 Neighboring gene uncharacterized LOC114116588 Neighboring gene uncharacterized LOC132658106 Neighboring gene CD58 molecule

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_056054.1 Chromosome 1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural arrangement and conformational dynamics of the gamma subunit of the Na+/K+-ATPase. Dempski RE, et al. Biochemistry, 2008 Jan 8. PMID 18081317
  2. Amino-acid sequence of the catalytic subunit of the (Na+ + K+)ATPase deduced from a complementary DNA. Shull GE, et al. Nature, 1985 Aug 22-28. PMID 2993903
  3. Lysine 480 is an essential residue in the putative ATP site of lamb kidney (Na,K)-ATPase. Identification of the pyridoxal 5'-diphospho-5'-adenosine and pyridoxal phosphate reactive residue. Hinz HR, et al. J Biol Chem, 1990 Jun 25. PMID 2162343

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest that there is no relative change in distance between the alpha and gamma subunits during ion transport.
    Title: Structural arrangement and conformational dynamics of the gamma subunit of the Na+/K+-ATPase.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables P-type sodium:potassium-exchanging transporter activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in intracellular potassium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intracellular sodium ion homeostasis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in potassium ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in proton transmembrane transport IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sodium ion export across plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
sodium/potassium-transporting ATPase subunit alpha-1
Names
Na(+)/K(+) ATPase alpha-1 subunit
sodium pump 1
sodium pump subunit alpha-1
sodium/potassium-transporting ATPase alpha-1 chain
NP_001009360.1
XP_027824133.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009360.1 → NP_001009360.1  sodium/potassium-transporting ATPase subunit alpha-1

    See identical proteins and their annotated locations for NP_001009360.1

    Status: PROVISIONAL

    Source sequence(s)
    X02813
    UniProtKB/Swiss-Prot
    P04074
    UniProtKB/TrEMBL
    A0A836D9U0, W5QG59
    Related
    ENSOARP00020000740.1, ENSOART00020000917.2
    Conserved Domains (1) summary
    TIGR01106
    Location:25 → 1021
    ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit

RefSeqs of Annotated Genomes: GCF_016772045.2-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ARS-UI_Ramb_v3.0 Primary Assembly

Genomic

  1. NC_056054.1 Reference ARS-UI_Ramb_v3.0 Primary Assembly

    Range
    93717246..93750077
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027968332.3 → XP_027824133.1  sodium/potassium-transporting ATPase subunit alpha-1 isoform X1

    UniProtKB/TrEMBL
    W5QG59
    Related
    ENSOARP00020000757.1, ENSOART00020000936.2
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P04074.1 GenPept UniProtKB/Swiss-Prot:P04074

Gene LinkOut

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