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PTGS1 prostaglandin-endoperoxide synthase 1 [ Ovis aries (sheep) ]

Gene ID: 443551, updated on 9-Feb-2019

Summary

Gene symbol
PTGS1
Gene description
prostaglandin-endoperoxide synthase 1
See related
Ensembl:ENSOARG00000014116
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Ovis aries
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Cetartiodactyla; Ruminantia; Pecora; Bovidae; Caprinae; Ovis
Also known as
COX1; COX-1; PGHS-1
Summary
This is one of two genes encoding similar enzymes that catalyze the conversion of arachinodate to prostaglandin. The encoded protein regulates angiogenesis in endothelial cells, and is inhibited by nonsteroidal anti-inflammatory drugs such as aspirin. Based on its ability to function as both a cyclooxygenase and as a peroxidase, the encoded protein has been identified as a moonlighting protein. [provided by RefSeq, Jan 2014]
Orthologs

Genomic context

See PTGS1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
103 current Oar_rambouillet_v1.0 (GCF_002742125.1) 3 NC_040254.1 (13938380..13963047, complement)
102 previous assembly Oar_v4.0 (GCF_000298735.2) 3 NC_019460.2 (13295718..13320592, complement)

Chromosome 3 - NC_040254.1Genomic Context describing neighboring genes Neighboring gene olfactory receptor 1L3-like Neighboring gene RNA-binding protein with multiple splicing 2 pseudogene Neighboring gene mitochondrial ribosome recycling factor Neighboring gene RNA binding motif protein 18

Genomic regions, transcripts, and products

Expression

  • Project title: Sheep Tissue Atlas
  • Description: Sheep total RNA was extracted from embryonic and adult tissues
  • BioProject: PRJEB6169
  • Publication: PMID 24904168
  • Analysis date: Mon Jan 29 09:33:46 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

General protein information

Preferred Names
prostaglandin G/H synthase 1
Names
PGH synthase 1
PHS 1
cyclooxygenase-1
prostaglandin H2 synthase 1
prostaglandin endoperoxide synthase
NP_001009476.1
XP_027821574.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009476.1NP_001009476.1  prostaglandin G/H synthase 1 precursor

    See identical proteins and their annotated locations for NP_001009476.1

    Status: PROVISIONAL

    Source sequence(s)
    Y00750
    UniProtKB/Swiss-Prot
    P05979
    Related
    ENSOARP00000015152, ENSOART00000015373
    Conserved Domains (2) summary
    cd09816
    Location:90576
    prostaglandin_endoperoxide_synthase; Animal prostaglandin endoperoxide synthase and related bacterial proteins
    cd00054
    Location:3370
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

RefSeqs of Annotated Genomes: Ovis aries Annotation Release 103 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Oar_rambouillet_v1.0 Primary Assembly

Genomic

  1. NC_040254.1 Reference Oar_rambouillet_v1.0 Primary Assembly

    Range
    13938380..13963047 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_027965773.1XP_027821574.1  prostaglandin G/H synthase 1 isoform X1

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