prkacab protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: prkacabprovided by ZNC
Official Full Name: protein kinase, cAMP-dependent, catalytic, alpha, genome duplicate bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040801-208
See related: Ensembl:ENSDARG00000016809 AllianceGenome:ZFIN:ZDB-GENE-040801-208
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:91856; CH1073-57O22.1
Summary: Predicted to enable protein kinase A regulatory subunit binding activity. Predicted to be involved in protein kinase A signaling. Predicted to act upstream of or within protein phosphorylation. Predicted to be active in nucleus. Is expressed in several structures, including central nervous system; fin bud; optic cup; pronephric duct; and retinal neural layer. Human ortholog(s) of this gene implicated in adrenal cortical adenoma; congestive heart failure; platelet-type bleeding disorder 19; and primary pigmented nodular adrenocortical disease. Orthologous to several human genes including PRKACA (protein kinase cAMP-activated catalytic subunit alpha). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 1

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (55843552..55873178, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (55165901..55195527, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb16b10.x1 (e-PCR)
- UniSTS:202961

fj05c04.y1 (e-PCR)
- UniSTS:198386

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables cAMP-dependent protein kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables cAMP-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase A regulatory subunit binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in protein kinase A signaling	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of cAMP-dependent protein kinase complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cAMP-dependent protein kinase catalytic subunit alpha

NP_001003470.1

EC 2.7.11.11

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001003470.1 → NP_001003470.1 cAMP-dependent protein kinase catalytic subunit alpha

See identical proteins and their annotated locations for NP_001003470.1

Status: PROVISIONAL

Source sequence(s)

BC078343

UniProtKB/TrEMBL

A0A8M1N167, Q6DBV8

Related

ENSDARP00000002825.5, ENSDART00000019936.6

Conserved Domains (2) summary

PTZ00263
Location:41 → 351

PTZ00263; protein kinase A catalytic subunit; Provisional

cd14209
Location:42 → 331

STKc_PKA; Catalytic subunit of the Serine/Threonine Kinase, cAMP-dependent protein kinase