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pitx paired superclass homeobox transcription factor [ Ciona intestinalis (vase tunicate) ]

Gene ID: 445699, updated on 21-Dec-2023

Summary

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Gene symbol
pitx
Gene description
paired superclass homeobox transcription factor
See related
Ensembl:ENSCING00000005285
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Ciona intestinalis
Lineage
Eukaryota; Metazoa; Chordata; Tunicata; Ascidiacea; Phlebobranchia; Cionidae; Ciona
Also known as
PITX1; Ci-Pitx
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Genomic context

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See pitx in Genome Data Viewer
Location:
chromosome: Un
Exon count:
6
Annotation release Status Assembly Chr Location
104 current KH (GCF_000224145.3) Unplaced Scaffold NW_004190397.2 (197661..213473)

NW_004190397.2Genomic Context describing neighboring genes Neighboring gene cyclin-H Neighboring gene histone deacetylase 8 Neighboring gene uncharacterized LOC101241921 Neighboring gene uncharacterized LOC100183321

Genomic regions, transcripts, and products

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Genomic Sequence:
NW_004190397 Unplaced Scaffold Reference KH Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Left-right asymmetric expression of Pitx is regulated by the asymmetric Nodal signaling through an intronic enhancer in Ciona intestinalis. Yoshida K, et al. Dev Genes Evol, 2008 Jul. PMID 18546017
  2. A modular cis-regulatory system controls isoform-specific pitx expression in ascidian stomodaeum. Christiaen L, et al. Dev Biol, 2005 Jan 15. PMID 15617693
  3. Pitx homeobox genes in Ciona and amphioxus show left-right asymmetry is a conserved chordate character and define the ascidian adenohypophysis. Boorman CJ, et al. Evol Dev, 2002 Sep-Oct. PMID 12356265
  4. Pitx genes in Tunicates provide new molecular insight into the evolutionary origin of pituitary. Christiaen L, et al. Gene, 2002 Apr 3. PMID 11992728
  5. Gene expression profiles of transcription factors and signaling molecules in the ascidian embryo: towards a comprehensive understanding of gene networks. Imai KS, et al. Development, 2004 Aug. PMID 15269171

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The regulatory mechanism controlling the left-right asymmetric expression of the Pitx genes is well conserved between C. intestinalis and vertebrates.
    Title: Left-right asymmetric expression of Pitx is regulated by the asymmetric Nodal signaling through an intronic enhancer in Ciona intestinalis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
paired superclass homeobox transcription factor
Names
pituitary homeobox pitx

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001032517.2 → NP_001027689.2  paired superclass homeobox transcription factor

    Status: VALIDATED

    Source sequence(s)
    EAAA01003470
    UniProtKB/TrEMBL
    A0A1W5BFA5, F6UIC4, Q5Y4Y7

RefSeqs of Annotated Genomes: Ciona intestinalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference KH Primary Assembly

Genomic

  1. NW_004190397.2 Reference KH Primary Assembly

    Range
    197661..213473
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_018815448.2 → XP_018670993.1  paired superclass homeobox transcription factor isoform X2

    UniProtKB/TrEMBL
    A0A1W5BFA5, F6UIC4, Q5Y4Y7

  2. XM_009863002.3 → XP_009861304.1  paired superclass homeobox transcription factor isoform X1

    See identical proteins and their annotated locations for XP_009861304.1

    UniProtKB/TrEMBL
    A0A1W3JHI4, Q4H2Y1
    Conserved Domains (2) summary
    pfam00046
    Location:258 → 309
    Homeobox; Homeobox domain
    pfam03826
    Location:425 → 442
    OAR; OAR domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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