MAP3K8 mitogen-activated protein kinase kinase kinase 8 [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: MAP3K8provided by VGNC
Official Full Name: mitogen-activated protein kinase kinase kinase 8provided by VGNC
Primary source: VGNC:VGNC:7238
Locus tag: CK820_G0018827
See related: Ensembl:ENSPTRG00000002400
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	8	NC_072406.2 (43429727..43458038)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	10	NC_072408.1 (33772458..33800325)

Chromosome 8 - NC_072406.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

MAP3K8_915 (e-PCR)
- UniSTS:468511

WI-14992 (e-PCR)
- UniSTS:70953

SHGC-35244 (e-PCR)
- UniSTS:59219

SHGC-78707 (e-PCR)
- UniSTS:95584

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info	PubMed
enables MAP kinase kinase kinase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in protein phosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: mitogen-activated protein kinase kinase kinase 8

XP_001137315.1

EC 2.7.1.-

EC 2.7.11.25

XP_001137395.1

EC 2.7.1.-

EC 2.7.11.25

XP_009456474.1

EC 2.7.1.-

EC 2.7.11.25

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

43429727..43458038

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_001137395.7 → XP_001137395.1 mitogen-activated protein kinase kinase kinase 8

See identical proteins and their annotated locations for XP_001137395.1

UniProtKB/TrEMBL

A0A2J8MN82, A0A6D2W586, H2Q1S6

Conserved Domains (1) summary

cd13995
Location:133 → 388

STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8
XM_009458199.4 → XP_009456474.1 mitogen-activated protein kinase kinase kinase 8

See identical proteins and their annotated locations for XP_009456474.1

UniProtKB/TrEMBL

A0A2J8MN82, A0A6D2W586, H2Q1S6

Conserved Domains (1) summary

cd13995
Location:133 → 388

STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8
XM_001137315.5 → XP_001137315.1 mitogen-activated protein kinase kinase kinase 8

See identical proteins and their annotated locations for XP_001137315.1

UniProtKB/TrEMBL

A0A2J8MN82, A0A6D2W586, H2Q1S6

Related

ENSPTRP00000004070.2

Conserved Domains (1) summary

cd13995
Location:133 → 388

STKc_MAP3K8; Catalytic domain of the Serine/Threonine kinase, Mitogen-Activated Protein Kinase (MAPK) Kinase Kinase 8