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MT-CO1 mitochondrially encoded cytochrome c oxidase I [ Homo sapiens (human) ]

Gene ID: 4512, updated on 25-Nov-2021

Summary

Official Symbol
MT-CO1provided by HGNC
Official Full Name
mitochondrially encoded cytochrome c oxidase Iprovided by HGNC
Primary source
HGNC:HGNC:7419
See related
MIM:516030
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
COI; MTCO1; COX1
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Genomic context

See MT-CO1 in Genome Data Viewer
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) MT (non-nuclear) NC_012920.1 (5904..7445)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) MT (non-nuclear) NC_012920.1 (5904..7445)

Chromosome MT - NC_012920.1Genomic Context describing neighboring genes Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA Neighboring gene tRNA

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Tat-induced mitochondrial membrane permeabilization is associated with inhibition of cytochrome c oxidase (COX) activity by Tat in disrupted mitochondria from human samples PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the COX1 gene: The COX1 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, A.thaliana, and frog.
  • Orthologs

Gene Ontology Provided by GOA

Function Evidence Code Pubs
contributes_to cytochrome-c oxidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
contributes_to cytochrome-c oxidase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
enables heme binding IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in aerobic respiration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in aging IEA
Inferred from Electronic Annotation
more info
 
involved_in cerebellum development IEA
Inferred from Electronic Annotation
more info
 
involved_in electron transport coupled proton transport IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitochondrial electron transport, cytochrome c to oxygen IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in respiratory electron transport chain IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in response to copper ion IEA
Inferred from Electronic Annotation
more info
 
involved_in response to electrical stimulus IEA
Inferred from Electronic Annotation
more info
 
involved_in response to oxidative stress IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
cytochrome c oxidase subunit I
YP_003024028.1
  • cytochrome c oxidase I

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012920.1 Reference assembly

    Range
    5904..7445
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. YP_003024028.1 cytochrome c oxidase subunit I (mitochondrion) [Homo sapiens]

    See identical proteins and their annotated locations for YP_003024028.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    P00395
    UniProtKB/TrEMBL
    U5YWV7
    Related
    ENSP00000354499.2
    Conserved Domains (1) summary
    MTH00153
    Location:5507
    COX1; cytochrome c oxidase subunit I; Provisional
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