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IleRS Isoleucyl-tRNA synthetase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 45785, updated on 10-May-2024

Summary

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Official Symbol
IleRSprovided by FlyBase
Official Full Name
Isoleucyl-tRNA synthetaseprovided by FlyBase
Primary source
FLYBASE:FBgn0027086
Locus tag
Dmel_CG11471
See related
AllianceGenome:FB:FBgn0027086
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Aats-ile; CG11471; Dmel\CG11471; IARS; IRS; IsoleuRS; l(3)00827
Summary
Predicted to enable isoleucine-tRNA ligase activity. Predicted to be involved in isoleucyl-tRNA aminoacylation. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including anterior endoderm; embryonic/larval muscle system; extended germ band embryo; gut section; and visceral muscle primordium. Orthologous to human IARS1 (isoleucyl-tRNA synthetase 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See IleRS in Genome Data Viewer
Location:
79D4-79D4; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (22288665..22292810)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (22281765..22285910)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR45960 Neighboring gene Serine-arginine protein kinase at 79D Neighboring gene HEM-protein Neighboring gene Tenascin major Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45963

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SUMOylation of Arginyl tRNA Synthetase Modulates the Drosophila Innate Immune Response. Nayak P, et al. Front Cell Dev Biol, 2021. PMID 34660574, Free PMC Article
  2. The multienzyme complex containing nine aminoacyl-tRNA synthetases is ubiquitous from Drosophila to mammals. Kerjan P, et al. Biochim Biophys Acta, 1994 Apr 21. PMID 8161568
  3. The HEM proteins: a novel family of tissue-specific transmembrane proteins expressed from invertebrates through mammals with an essential function in oogenesis. Baumgartner S, et al. J Mol Biol, 1995 Aug 4. PMID 7643388
  4. WRS-85D: A tryptophanyl-tRNA synthetase expressed to high levels in the developing Drosophila salivary gland. Seshaiah P, et al. Mol Biol Cell, 1999 May. PMID 10233165, Free PMC Article
  5. A mosaic genetic screen for novel mutations affecting Drosophila neuroblast divisions. Slack C, et al. BMC Genet, 2006 Jun 2. PMID 16749923, Free PMC Article

See all (46) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA editing activity IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables isoleucine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables isoleucine-tRNA ligase activity TAS
Traceable Author Statement
more info
 PubMed 
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in isoleucyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in isoleucyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in isoleucyl-tRNA aminoacylation TAS
Traceable Author Statement
more info
 PubMed 
involved_in tRNA aminoacylation for protein translation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Isoleucyl-tRNA synthetase
Names
CG11471-PA
CG11471-PC
CG11471-PD
IleRS-PA
IleRS-PC
IleRS-PD
NP_524840.2
NP_730716.1
NP_788565.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    22288665..22292810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_168952.4 → NP_730716.1  Isoleucyl-tRNA synthetase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730716.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSW0
    Related
    FBpp0078150
    Conserved Domains (3) summary
    cd07961
    Location:650 → 847
    Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
    cd00818
    Location:373 → 650
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PLN02882
    Location:9 → 1094
    PLN02882; aminoacyl-tRNA ligase

  2. NM_176387.2 → NP_788565.1  Isoleucyl-tRNA synthetase, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_788565.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSW0
    Related
    FBpp0078152
    Conserved Domains (3) summary
    cd07961
    Location:650 → 847
    Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
    cd00818
    Location:373 → 650
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PLN02882
    Location:9 → 1094
    PLN02882; aminoacyl-tRNA ligase

  3. NM_080101.4 → NP_524840.2  Isoleucyl-tRNA synthetase, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524840.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q8MSW0
    Related
    FBpp0078151
    Conserved Domains (3) summary
    cd07961
    Location:650 → 847
    Anticodon_Ia_Ile_ABEc; Anticodon-binding domain of archaeal, bacterial, and eukaryotic cytoplasmic isoleucyl tRNA synthetases
    cd00818
    Location:373 → 650
    IleRS_core; catalytic core domain of isoleucyl-tRNA synthetases
    PLN02882
    Location:9 → 1094
    PLN02882; aminoacyl-tRNA ligase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSW0 Q8MSW0

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