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cype cyclope [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46040, updated on 11-Apr-2024

Summary

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Official Symbol
cypeprovided by FlyBase
Official Full Name
cyclopeprovided by FlyBase
Primary source
FLYBASE:FBgn0015031
Locus tag
Dmel_CG14028
See related
AllianceGenome:FB:FBgn0015031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
BcDNA:GH04604; CG14028; CG18323; Cox6c; COX6C; COXH; COXVIc; cyc; Cyc; Cype; Dmel\CG14028; l(2)03771; Q9VMS1; VIc
Summary
Predicted to enable cytochrome-c oxidase activity. Located in mitochondrion. Is expressed in several structures, including adult heart; gonad; imaginal disc; neuroblasts; and presumptive embryonic/larval central nervous system. Used to study cytochrome-c oxidase deficiency disease. Orthologous to human COX6C (cytochrome c oxidase subunit 6C). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
25D6-25D6; 2-16 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2L NT_033779.5 (5327227..5327969)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2L NT_033779.4 (5327227..5327969)

Chromosome 2L - NT_033779.5Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Nuclear receptor coactivator 6 Neighboring gene long non-coding RNA:CR44985 Neighboring gene uncharacterized protein Neighboring gene Turandot M

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Drosophila mechanosensory transduction channel. Walker RG, et al. Science, 2000 Mar 24. PMID 10744543
  2. The Mitochondria-Targeted Plastoquinone-Derivative SkQ1 Promotes Health and Increases Drosophila melanogaster Longevity in Various Environments. Tsybul'ko E, et al. J Gerontol A Biol Sci Med Sci, 2017 Apr 1. PMID 27166099, Free PMC Article
  3. Expression of the Ciona intestinalis alternative oxidase (AOX) in Drosophila complements defects in mitochondrial oxidative phosphorylation. Fernandez-Ayala DJ, et al. Cell Metab, 2009 May. PMID 19416715
  4. Presynaptic calcium channel localization and calcium-dependent synaptic vesicle exocytosis regulated by the Fuseless protein. Long AA, et al. J Neurosci, 2008 Apr 2. PMID 18385325, Free PMC Article
  5. Cytochrome c oxidase loses catalytic activity and structural integrity during the aging process in Drosophila melanogaster. Ren JC, et al. Biochem Biophys Res Commun, 2010 Oct 8. PMID 20833144, Free PMC Article

See all (68) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Component Evidence Code Pubs
part_of mitochondrial respiratory chain complex IV ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
cyclope
Names
CG14028-PA
CG14028-PB
CG14028-PC
cype-PA
cype-PB
cype-PC
cytochrome c oxidase VIc
cytochrome c oxidase polypeptide VIc
cytochrome c oxidase subunit 6C
subunit VIc

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033779.5 Reference assembly

    Range
    5327227..5327969
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001258957.2 → NP_001245886.1  cyclope, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245886.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UT3, Q9VMS1
    Conserved Domains (1) summary
    cd00927
    Location:8 → 77
    Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  2. NM_080526.3 → NP_536787.1  cyclope, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_536787.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UT3, Q9VMS1
    Related
    FBpp0078707
    Conserved Domains (1) summary
    cd00927
    Location:8 → 77
    Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...

  3. NM_001258956.2 → NP_001245885.1  cyclope, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001245885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q95UT3, Q9VMS1
    Conserved Domains (1) summary
    cd00927
    Location:8 → 77
    Cyt_c_Oxidase_VIc; Cytochrome c oxidase subunit VIc. Cytochrome c oxidase (CcO), the terminal oxidase in the respiratory chains of eukaryotes and most bacteria, is a multi-chain transmembrane protein located in the inner membrane of mitochondria and the cell membrane of ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8MSK4 Q8MSK4
Q9VMS1 Q9VMS1

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