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Prosbeta1 Proteasome beta1 subunit [ Drosophila melanogaster (fruit fly) ]

Gene ID: 46058, updated on 4-Apr-2024

Summary

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Official Symbol
Prosbeta1provided by FlyBase
Official Full Name
Proteasome beta1 subunitprovided by FlyBase
Primary source
FLYBASE:FBgn0010590
Locus tag
Dmel_CG8392
See related
AllianceGenome:FB:FBgn0010590
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
1(2)05070; 8392; Beta 1 subunit; beta-1; Beta-1; beta1; B[[1]]; CG8392; Dmel\CG8392; l(2)05070; prosbeta1
Summary
Predicted to enable endopeptidase activity. Predicted to be involved in proteasome-mediated ubiquitin-dependent protein catabolic process. Part of proteasome core complex. Is expressed in adult head; adult heart; germline cell; organism; and primordial germ cell. Human ortholog(s) of this gene implicated in autoimmune disease (multiple); lymphoma; and renal cell carcinoma. Orthologous to several human genes including PSMB6 (proteasome 20S subunit beta 6). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
52D13-52D14; 2-76 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (16013805..16014787, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (11901310..11902292, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene Transmembrane protein 131 Neighboring gene Ubiquitin-fold modifier conjugating enzyme 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene Rrp42 Neighboring gene ER membrane protein complex subunit 7 Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The proteasome beta 5 subunit is essential for sexually divergent adaptive homeostatic responses to oxidative stress in D. melanogaster. Pomatto LCD, et al. Free Radic Biol Med, 2020 Nov 20. PMID 32758664, Free PMC Article
  2. The age- and sex-specific decline of the 20s proteasome and the Nrf2/CncC signal transduction pathway in adaption and resistance to oxidative stress in Drosophila melanogaster. Pomatto LCD, et al. Aging (Albany NY), 2017 Apr. PMID 28373600, Free PMC Article
  3. Comparative Ubiquitome Analysis Reveals Deubiquitinating Effects Induced by Wolbachia Infection in Drosophila melanogaster. Zong Q, et al. Int J Mol Sci, 2022 Aug 21. PMID 36012723, Free PMC Article
  4. A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. Pickering AM, et al. J Exp Biol, 2013 Feb 15. PMID 23038734, Free PMC Article
  5. Proteasome β5 subunit overexpression improves proteostasis during aging and extends lifespan in Drosophila melanogaster. Nguyen NN, et al. Sci Rep, 2019 Feb 28. PMID 30816680, Free PMC Article

See all (78) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables endopeptidase activity IC
Inferred by Curator
more info
 PubMed 
enables endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables threonine-type endopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IC
Inferred by Curator
more info
 PubMed 
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in proteolysis involved in protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex IEA
Inferred from Electronic Annotation
more info
  
part_of proteasome core complex, beta-subunit complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of proteasome core complex, beta-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
proteasome beta1 subunit
Names
CG8392-PA
Prosbeta1-PA
beta1
lethal (2) 05070
NP_652031.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    16013805..16014787 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_143774.3 → NP_652031.2  proteasome beta1 subunit [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_652031.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0AQH0, Q8SYQ2, Q95SA6
    Related
    FBpp0086400
    Conserved Domains (2) summary
    TIGR03690
    Location:15 → 201
    20S_bact_beta; proteasome, beta subunit, bacterial type
    cd03762
    Location:16 → 203
    proteasome_beta_type_6; proteasome beta type-6 subunit. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0AQH0 A0AQH0
Q8SYQ2 Q8SYQ2
Q95SA6 Q95SA6

Gene LinkOut

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