MYH10 myosin heavy chain 10 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYH10provided by HGNC
Official Full Name: myosin heavy chain 10provided by HGNC
Primary source: HGNC:HGNC:7568
See related: Ensembl:ENSG00000133026 MIM:160776
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: NMMHCB; NMMHC-IIB
Summary: This gene encodes a member of the myosin superfamily. The protein represents a conventional non-muscle myosin; it should not be confused with the unconventional myosin-10 (MYO10). Myosins are actin-dependent motor proteins with diverse functions including regulation of cytokinesis, cell motility, and cell polarity. Mutations in this gene have been associated with May-Hegglin anomaly and developmental defects in brain and heart. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression: Broad expression in lung (RPKM 33.9), placenta (RPKM 28.3) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 17p13.1

Exon count:: 47

Annotation release	Status	Assembly	Chr	Location
109.20210514	current	GRCh38.p13 (GCF_000001405.39)	17	NC_000017.11 (8474212..8631369, complement)
105.20201022	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (8377530..8534043, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Title: The distinct roles of myosin IIA and IIB under compression stress in nucleus pulposus cells.
Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
Title: Network-based analysis reveals novel gene signatures in the peripheral blood of patients with sporadic nonsyndromic thoracic aortic aneurysm.
survivin binds to non-muscle myosin II (NMII), regulating its filament assembly.
Title: A direct interaction between survivin and myosin II is required for cytokinesis.
Non-muscle myosin IIA (NMIIA) provides the mechanical tugging force necessary for cell-cell junction reinforcement and maintenance. Non-muscle myosin IIB (NMIIB) is involved in E-cadherin clustering, maintenance of a branched actin layer connecting E-cadherin complexes and perijunctional actin fibers in the biogenesis and integrity of adherens junctions.
Title: Myosin II isoforms play distinct roles in <i>adherens</i> junction biogenesis.
Nonmuscle myosin II is an actin-based motor that executes numerous mechanical tasks in cells including spatiotemporal organization of the actin cytoskeleton, adhesion, migration, cytokinesis, tissue remodeling, and membrane trafficking. It is ubiquitously expressed in mammalian cells as a tissue-specific combination of three paralogs. (Review)
Title: Mammalian nonmuscle myosin II comes in three flavors.
In human glioma cell lines, silencing the MYH10 gene reduced cell migration and invasion, by inhibiting the Wnt/beta-catenin pathway, which may regulate the ECM and inhibit EMT in human glioma.
Title: Myosin Heavy Chain 10 (MYH10) Gene Silencing Reduces Cell Migration and Invasion in the Glioma Cell Lines U251, T98G, and SHG44 by Inhibiting the Wnt/β-Catenin Pathway.
Myosin IIA and IIB are essential for the formation of transverse arcs and ventral stress fibers, respectively. Furthermore, the study illustrated the roles of both isoforms in lamellar flattening and also raised the possibility that actin filaments in ventral stress fibers are in a stretched conformation.
Title: Different contributions of nonmuscle myosin IIA and IIB to the organization of stress fiber subtypes in fibroblasts.
These distinct functions of NMIIA and NMIIB might promote intrinsic and directed migration of normal human fibroblasts.
Title: Nonmuscle myosin IIA and IIB differentially contribute to intrinsic and directed migration of human embryonic lung fibroblasts.
cellular quiescence induces Mec17 to couple the production of acetylated microtubules and Myh10, whose accumulation overcomes the inhibitory role of Myh9 and initiates ciliogenesis
Title: A Mec17-Myosin II Effector Axis Coordinates Microtubule Acetylation and Actin Dynamics to Control Primary Cilium Biogenesis.
We identify three mosaic missense and likely-gene disrupting mutations in genes previously implicated in ASD (KMT2C, NCKAP1, and MYH10) in probands but none in siblings. We find a strong ascertainment bias for mosaic mutations in probands relative to their unaffected siblings
Title: The Contribution of Mosaic Variants to Autism Spectrum Disorder.

Submit: New GeneRIF Correction See all GeneRIFs (49)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2019-01-23) ClinGen Genome Curation Page Haploinsufficency Little evidence for dosage pathogenicity (Last evaluated 2019-01-23) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Interaction of HIV-1 Gag with myosin, heavy chain 10, non-muscle (MYH10) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Tat	tat	The centripetal and lateral movements of the HIV-1 Tat protein transduction domain are linked to the integrity of myosin II-based actin contraction in HeLa cells	PubMed
retropepsin	gag-pol	HIV-1 protease cleaves human myosin heavy chain in vitro	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH36627 (e-PCR)
- UniSTS:74525

MYH10_2175 (e-PCR)
- UniSTS:280861

SHGC-146743 (e-PCR)
- UniSTS:175407

RH15854 (e-PCR)
- UniSTS:16696

MARC_24284-24285:1030045561:1 (e-PCR)
- UniSTS:268872

SHGC-12899 (e-PCR)
- UniSTS:11870

RH12874 (e-PCR)
- UniSTS:75110

SHGC-32450 (e-PCR)
- UniSTS:29035

A004M39 (e-PCR)
- UniSTS:27039

RH18038 (e-PCR)
- UniSTS:28860

RH93338 (e-PCR)
- UniSTS:91600

D17S647 (e-PCR)
- UniSTS:9948

RH12513 (e-PCR)
- UniSTS:59113

D17S1384E (e-PCR)
- UniSTS:69106

Homology

Homologs of the MYH10 gene: The MYH10 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, fruit fly, mosquito, C.elegans, and frog.
Orthologs from Annotation Pipeline: 276 organisms have orthologs with human gene MYH10
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ADP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	IDA Inferred from Direct Assay more info	PubMed
enables ATP binding	NAS Non-traceable Author Statement more info	PubMed
enables RNA stem-loop binding	IDA Inferred from Direct Assay more info	PubMed
enables actin binding	NAS Non-traceable Author Statement more info	PubMed
enables actin filament binding	IDA Inferred from Direct Assay more info	PubMed
contributes_to actin filament binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables mRNA 5'-UTR binding	IDA Inferred from Direct Assay more info	PubMed
enables microfilament motor activity	IDA Inferred from Direct Assay more info	PubMed
contributes_to microfilament motor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin filament-based movement	IDA Inferred from Direct Assay more info	PubMed
involved_in actomyosin structure organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell adhesion	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cytokinesis	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of protein secretion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cell shape	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in actomyosin	IDA Inferred from Direct Assay more info	PubMed
located_in cell cortex	IDA Inferred from Direct Assay more info	PubMed
located_in cleavage furrow	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IMP Inferred from Mutant Phenotype more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	HDA more info	PubMed
located_in lamellipodium	IEA Inferred from Electronic Annotation more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
part_of myosin II complex	IDA Inferred from Direct Assay more info	PubMed
located_in myosin II filament	IDA Inferred from Direct Assay more info	PubMed
part_of myosin complex	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	HDA more info	PubMed
part_of polysome	IMP Inferred from Mutant Phenotype more info	PubMed
located_in stress fiber	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: myosin-10

Names: myosin heavy chain, nonmuscle type B; myosin, heavy chain 10, non-muscle; myosin, heavy polypeptide 10, non-muscle; nonmuscle myosin II heavy chain-B; nonmuscle myosin heavy chain IIB

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042305.2 RefSeqGene

Range

5037..161538

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001256012.3 → NP_001242941.1 myosin-10 isoform 1

See identical proteins and their annotated locations for NP_001242941.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC011061, AC025518, AC026130

Consensus CDS

CCDS58515.1

UniProtKB/Swiss-Prot

P35580

UniProtKB/TrEMBL

G1UI33

Related

ENSP00000353590.4, ENST00000360416.8

Conserved Domains (3) summary

cd14920
Location:99 → 802

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:879 → 1959

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
NM_001256095.2 → NP_001243024.1 myosin-10 isoform 3

See identical proteins and their annotated locations for NP_001243024.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, and lacks an alternate in-frame exon in the central coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.

Source sequence(s)

AC011061, AC025518, AC026130

Consensus CDS

CCDS73984.1

UniProtKB/Swiss-Prot

P35580

Related

ENSP00000369315.5, ENST00000379980.8

Conserved Domains (3) summary

cd14920
Location:99 → 780

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:857 → 1937

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
NM_001375266.1 → NP_001362195.1 myosin-10 isoform 4

Status: REVIEWED

Source sequence(s)

AC011061, AC025518, AC026130

Conserved Domains (3) summary

cd14920
Location:99 → 781

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:858 → 1938

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
NM_005964.5 → NP_005955.3 myosin-10 isoform 2

See identical proteins and their annotated locations for NP_005955.3

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in both the 5' and central coding regions, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.

Source sequence(s)

AC011061, AC025518, AC026130

Consensus CDS

CCDS11144.1

UniProtKB/Swiss-Prot

P35580

Related

ENSP00000269243.4, ENST00000269243.8

Conserved Domains (3) summary

cd14920
Location:99 → 771

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

NC_000017.11 Reference GRCh38.p13 Primary Assembly

Range

8474212..8631369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011523878.2 → XP_011522180.1 myosin-10 isoform X1

Conserved Domains (11) summary

COG5134
Location:1378 → 1506

COG5134; Uncharacterized conserved protein [Function unknown]

cd14920
Location:129 → 811

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:117 → 811

Myosin_head; Myosin head (motor domain)

pfam01576
Location:888 → 1968

Myosin_tail_1; Myosin tail

pfam02736
Location:64 → 102

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1640 → 1650

GBP_C; coiled coil [structural motif]

cl19219
Location:1084 → 1173

DUF342; Protein of unknown function (DUF342)

cl19511
Location:1151 → 1262

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

cl19818
Location:1685 → 1736

DUF106; Integral membrane protein DUF106

cl20817
Location:1544 → 1650

GBP_C; Guanylate-binding protein, C-terminal domain

cl24005
Location:1813 → 1907

DUF2570; Protein of unknown function (DUF2570)
XM_017024680.1 → XP_016880169.1 myosin-10 isoform X5

UniProtKB/Swiss-Prot

P35580

Conserved Domains (3) summary

cd14920
Location:99 → 780

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:857 → 1937

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_011523880.2 → XP_011522182.1 myosin-10 isoform X3

Conserved Domains (11) summary

COG5134
Location:1368 → 1496

COG5134; Uncharacterized conserved protein [Function unknown]

cd14920
Location:129 → 801

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:117 → 801

Myosin_head; Myosin head (motor domain)

pfam01576
Location:878 → 1958

Myosin_tail_1; Myosin tail

pfam02736
Location:64 → 102

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1630 → 1640

GBP_C; coiled coil [structural motif]

cl19219
Location:1074 → 1163

DUF342; Protein of unknown function (DUF342)

cl19511
Location:1141 → 1252

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

cl19818
Location:1675 → 1726

DUF106; Integral membrane protein DUF106

cl20817
Location:1534 → 1640

GBP_C; Guanylate-binding protein, C-terminal domain

cl24005
Location:1803 → 1897

DUF2570; Protein of unknown function (DUF2570)
XM_011523879.2 → XP_011522181.1 myosin-10 isoform X2

Conserved Domains (11) summary

COG5134
Location:1377 → 1505

COG5134; Uncharacterized conserved protein [Function unknown]

cd14920
Location:129 → 810

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:117 → 810

Myosin_head; Myosin head (motor domain)

pfam01576
Location:887 → 1967

Myosin_tail_1; Myosin tail

pfam02736
Location:64 → 102

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1639 → 1649

GBP_C; coiled coil [structural motif]

cl19219
Location:1083 → 1172

DUF342; Protein of unknown function (DUF342)

cl19511
Location:1150 → 1261

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

cl19818
Location:1684 → 1735

DUF106; Integral membrane protein DUF106

cl20817
Location:1543 → 1649

GBP_C; Guanylate-binding protein, C-terminal domain

cl24005
Location:1812 → 1906

DUF2570; Protein of unknown function (DUF2570)
XM_011523875.2 → XP_011522177.1 myosin-10 isoform X7

Conserved Domains (11) summary

COG5134
Location:1399 → 1527

COG5134; Uncharacterized conserved protein [Function unknown]

cd14920
Location:129 → 832

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam00063
Location:117 → 832

Myosin_head; Myosin head (motor domain)

pfam01576
Location:909 → 1989

Myosin_tail_1; Myosin tail

pfam02736
Location:64 → 102

Myosin_N; Myosin N-terminal SH3-like domain

cd16269
Location:1661 → 1671

GBP_C; coiled coil [structural motif]

cl19219
Location:1105 → 1194

DUF342; Protein of unknown function (DUF342)

cl19511
Location:1172 → 1283

DUF2317; Uncharacterized protein conserved in bacteria (DUF2317)

cl19818
Location:1706 → 1757

DUF106; Integral membrane protein DUF106

cl20817
Location:1565 → 1671

GBP_C; Guanylate-binding protein, C-terminal domain

cl24005
Location:1834 → 1928

DUF2570; Protein of unknown function (DUF2570)
XM_017024681.1 → XP_016880170.1 myosin-10 isoform X6

UniProtKB/Swiss-Prot

P35580

Conserved Domains (3) summary

cd14920
Location:99 → 771

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_017024678.1 → XP_016880167.1 myosin-10 isoform X4

Conserved Domains (3) summary

cd14920
Location:99 → 781

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:858 → 1938

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_017024679.1 → XP_016880168.1 myosin-10 isoform X4

Conserved Domains (3) summary

cd14920
Location:99 → 781

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:858 → 1938

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain
XM_017024682.1 → XP_016880171.1 myosin-10 isoform X6

UniProtKB/Swiss-Prot

P35580

Conserved Domains (3) summary

cd14920
Location:99 → 771

MYSc_Myh10; class II myosin heavy chain 10, motor domain

pfam01576
Location:848 → 1928

Myosin_tail_1; Myosin tail

pfam02736
Location:33 → 72

Myosin_N; Myosin N-terminal SH3-like domain