PTEN phosphatase and tensin homolog [Pan troglodytes (chimpanzee)] - Gene

Summary

Official Symbol: PTENprovided by VGNC
Official Full Name: phosphatase and tensin homologprovided by VGNC
Primary source: VGNC:VGNC:12442
Locus tag: CK820_G0004392
See related: Ensembl:ENSPTRG00000002719
Gene type: protein coding
RefSeq status: MODEL
Organism: Pan troglodytes
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Pan
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	NHGRI_mPanTro3-v2.0_pri (GCF_028858775.2)	8	NC_072406.2 (100082916..100187838)
RS_2023_04	previous assembly	NHGRI_mPanTro3-v1.1-hic.freeze_pri (GCF_028858775.1)	10	NC_072408.1 (90704042..90808899)

Chromosome 8 - NC_072406.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Pathways from PubChem

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General gene information

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Markers

PMC20246P1 (e-PCR)
- UniSTS:271890

STS-H71499 (e-PCR)
- UniSTS:5911

G19918 (e-PCR)
- UniSTS:77108

RH66859 (e-PCR)
- UniSTS:92239

RH92455 (e-PCR)
- UniSTS:85842

RH122960 (e-PCR)
- UniSTS:135257

RH122724 (e-PCR)
- UniSTS:133995

AFMA086WG9 (e-PCR)
- UniSTS:2163

PTEN_234 (e-PCR)
- UniSTS:468624

MARC_17017-17018:1023291848:1 (e-PCR)
- UniSTS:268185

Pten (e-PCR), detects polymorphism
- UniSTS:144288

STS-W73720 (e-PCR)
- UniSTS:71597

PMC154149P1 (e-PCR)
- UniSTS:271292

PMC88770P1 (e-PCR)
- UniSTS:273605

PMC88770P2 (e-PCR)
- UniSTS:273606

PMC88770P3 (e-PCR)
- UniSTS:273607

RH103681 (e-PCR)
- UniSTS:98006

RH79866 (e-PCR)
- UniSTS:90866

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables inositol-1,3,4,5-tetrakisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables phosphatidylinositol-3,4-bisphosphate 3-phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables protein tyrosine/serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in cell motility	IEA Inferred from Electronic Annotation more info	PubMed
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed
involved_in phosphatidylinositol dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in protein dephosphorylation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cell projection	IEA Inferred from Electronic Annotation more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN; phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

Names: phosphatase and tensin homolog (mutated in multiple advanced cancers 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: GCF_028858775.2-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Genomic

NC_072406.2 Reference NHGRI_mPanTro3-v2.0_pri Primary Assembly

Range

100082916..100187838

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_054659762.2 → XP_054515737.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X5
XM_063780859.1 → XP_063636929.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X4
XM_016918822.4 → XP_016774311.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X3

UniProtKB/TrEMBL

A0A2I3TAR7, A0A2I3TNH3, A0A2J8PEH9, A0A6D2VUZ1

Related

ENSPTRP00000090779.1

Conserved Domains (2) summary

cd14509
Location:24 → 181

PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog

pfam10409
Location:188 → 349

PTEN_C2; C2 domain of PTEN tumor-suppressor protein
XM_054659760.2 → XP_054515735.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X1
XM_016918820.4 → XP_016774309.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X2

UniProtKB/TrEMBL

A0A2I3TAR7

Conserved Domains (2) summary

cd14509
Location:24 → 166

PTP_PTEN; protein tyrosine phosphatase-like catalytic domain of phosphatase and tensin homolog

pfam10409
Location:173 → 334

PTEN_C2; C2 domain of PTEN tumor-suppressor protein
XM_063780860.1 → XP_063636930.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X4
XM_054659763.2 → XP_054515738.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X6
XM_016918823.4 → XP_016774312.1 phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN isoform X7

Conserved Domains (1) summary

pfam10409
Location:1 → 152

PTEN_C2; C2 domain of PTEN tumor-suppressor protein