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Men Malic enzyme [ Drosophila melanogaster (fruit fly) ]

Gene ID: 47173, updated on 11-Apr-2024

Summary

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Official Symbol
Menprovided by FlyBase
Official Full Name
Malic enzymeprovided by FlyBase
Primary source
FLYBASE:FBgn0002719
Locus tag
Dmel_CG10120
See related
AllianceGenome:FB:FBgn0002719
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.278; CG10120; Dmel\CG10120; MDH; Mdh-NADP; Me; ME; ME1; mem; men; MEN
Summary
Enables malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in several processes, including NADPH regeneration; determination of adult lifespan; and malate metabolic process. Located in cytosol. Is expressed in several structures, including central nervous system; circulatory system; embryonic/larval muscle system; epidermis; and extended germ band embryo. Orthologous to several human genes including ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
87C6-87C7; 3-52 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (12713103..12722442, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (8538825..8548164, complement)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Ninjurin C Neighboring gene Putative Achaete Scute Target 1 Neighboring gene uncharacterized protein Neighboring gene DNA polymerase theta Neighboring gene long non-coding RNA:CR44231 Neighboring gene UDP-glycosyltransferase family 37 member A2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background. Rzezniczak TZ, et al. Genetics, 2023 Feb 9. PMID 36482767, Free PMC Article
  2. Biological Effects of Single-Nucleotide Polymorphisms in the Drosophila melanogaster Malic Enzyme Locus. Baath S, et al. Biochem Genet, 2020 Feb. PMID 31302799
  3. A combination of structural and cis-regulatory factors drives biochemical differences in Drosophila melanogaster malic enzyme. Rzezniczak TZ, et al. Biochem Genet, 2012 Dec. PMID 22733181
  4. Nonclassical regulation of transcription: interchromosomal interactions at the malic enzyme locus of Drosophila melanogaster. Lum TE, et al. Genetics, 2011 Nov. PMID 21900270, Free PMC Article
  5. Regulation of Nadp-Malic Enzyme in the Eye-Antennal Disc of D. melanogaster/D. simulans Hybrids: Evidence for cis- and trans-Regulation. Kuhn DT, et al. Genetics, 1987 Feb. PMID 17246365, Free PMC Article

See all (144) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.
    Title: Regulation at Drosophila's Malic Enzyme highlights the complexity of transvection and its sensitivity to genetic background.
  2. these results suggest that metabolic changes mediated by Men during development might be related to the control of ROS tolerance and the longevity of Drosophila.
    Title: Overexpression of malic enzyme in the larval stage extends Drosophila lifespan.
  3. trans-interaction between alleles of the Malic enzyme (Men) locus in Drosophila melanogaster
    Title: Nonclassical regulation of transcription: interchromosomal interactions at the malic enzyme locus of Drosophila melanogaster.
  4. Studies suggest that variation in levels of cytoplasmic malic enzyme may contribute to variation in alcohol consumption.
    Title: Alcohol sensitivity in Drosophila: translational potential of systems genetics.
  5. Malic Enzyme is regulated by juvenile hormone by two mechanisms. One is by a direct effect of JH on the enzyme. The other is by stimulation of transcription of the MEN gene.
    Title: Regulation of cytosolic malate dehydrogenase by juvenile hormone in Drosophila melanogaster.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables malate dehydrogenase (decarboxylating) (NADP+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables malate dehydrogenase (decarboxylating) (NADP+) activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables malic enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in NADH metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in NADPH regeneration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in malate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in malate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of negative regulation of apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sleep IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
malic enzyme
Names
CG10120-PA
CG10120-PB
CG10120-PC
Men-PA
Men-PB
Men-PC
NADP-dependent malate dehydrogenase
NADP-malic enzyme
malic enzyme (cytosolic)
NP_001262509.1
NP_524880.2
NP_731739.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    12713103..12722442 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_080141.4 → NP_524880.2  malic enzyme, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524880.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NIW2, Q9VG31
    Related
    FBpp0082129
    Conserved Domains (3) summary
    cd05312
    Location:473 → 750
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:213 → 757
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:282 → 463
    malic; Malic enzyme, N-terminal domain

  2. NM_169479.2 → NP_731739.1  malic enzyme, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_731739.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9NIW1, Q9VG32
    Related
    FBpp0082130
    Conserved Domains (3) summary
    cd05312
    Location:469 → 746
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:209 → 753
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:278 → 459
    malic; Malic enzyme, N-terminal domain

  3. NM_001275580.1 → NP_001262509.1  malic enzyme, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001262509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H7BWU6, H7BWU8, Q2QBM1, Q9NIW0
    Conserved Domains (3) summary
    cd05312
    Location:288 → 565
    NAD_bind_1_malic_enz; NAD(P) binding domain of malic enzyme (ME), subgroup 1
    PLN03129
    Location:28 → 572
    PLN03129; NADP-dependent malic enzyme; Provisional
    pfam00390
    Location:97 → 278
    malic; Malic enzyme, N-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q2QBM1 Q2QBM1
Q9NIW0 Q9NIW0
Q9NIW1 Q9NIW1
Q9NIW2 Q9NIW2
Q9U1J1 Q9U1J1
Q9VG31 Q9VG31
Q9VG32 Q9VG32

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