Rbm4b RNA binding motif protein 4B [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Rbm4bprovided by RGD
Official Full Name: RNA binding motif protein 4Bprovided by RGD
Primary source: RGD:1359343
See related: Ensembl:ENSRNOG00000061795 AllianceGenome:RGD:1359343
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in entrainment of circadian clock by photoperiod; mRNA splicing, via spliceosome; and regulation of gene expression. Predicted to act upstream of or within positive regulation of gene expression. Predicted to be located in cytosol and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in nuclear speck. Orthologous to human RBM4B (RNA binding motif protein 4B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in Testes (RPKM 128.1), Thymus (RPKM 102.2) and 9 other tissues See more
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Genomic context

Location:: 1q43

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (211477337..211487428)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (202047934..202058025)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (220009397..220019488)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

AA955538 (e-PCR)
- UniSTS:261166

AA957251 (e-PCR)
- UniSTS:248116

RH144046 (e-PCR)
- UniSTS:233292

Rbm4b (e-PCR), detects polymorphism
- UniSTS:479057

RH70506 (e-PCR)
- UniSTS:88660

BE096290 (e-PCR)
- UniSTS:260511

RH141150 (e-PCR)
- UniSTS:223146

NoName (e-PCR)
- UniSTS:492235

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in circadian regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in circadian regulation of gene expression	ISS Inferred from Sequence or Structural Similarity more info
involved_in circadian rhythm	ISO Inferred from Sequence Orthology more info
involved_in circadian rhythm	ISS Inferred from Sequence or Structural Similarity more info
involved_in entrainment of circadian clock by photoperiod	ISO Inferred from Sequence Orthology more info
involved_in entrainment of circadian clock by photoperiod	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: RNA-binding protein 4B

Names: RNA-binding motif protein 30; RNA-binding protein 30; zinc-responsive protein ZD7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007014.2 → NP_001007015.2 RNA-binding protein 4B

See identical proteins and their annotated locations for NP_001007015.2

Status: PROVISIONAL

Source sequence(s)

BC086416

UniProtKB/Swiss-Prot

Q5U1X3, Q64LC9

UniProtKB/TrEMBL

A6HYY7

Related

ENSRNOP00000071527.1, ENSRNOT00000084410.2

Conserved Domains (4) summary

PTZ00368
Location:145 → 181

PTZ00368; universal minicircle sequence binding protein (UMSBP); Provisional

smart00343
Location:161 → 176

ZnF_C2HC; zinc finger

cd12606
Location:2 → 68

RRM1_RBM4; RNA recognition motif 1 (RRM1) found in vertebrate RNA-binding protein 4 (RBM4)

cd12607
Location:78 → 144

RRM2_RBM4; RNA recognition motif 2 (RRM2) found in vertebrate RNA-binding protein 4 (RBM4)