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MBP myelin basic protein [ Canis lupus familiaris (dog) ]

Gene ID: 476160, updated on 5-Mar-2024

Summary

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Official Symbol
MBPprovided by VGNC
Official Full Name
myelin basic proteinprovided by VGNC
Primary source
VGNC:VGNC:53736
See related
Ensembl:ENSCAFG00845000353
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
10
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (2644339..2759352)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (3844963..3959816)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (2810294..2925302)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (2689655..2804648)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (2640084..2755067)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene 60S ribosomal protein L10-like Neighboring gene small nucleolar RNA SNORA70 Neighboring gene galanin receptor 1 Neighboring gene zinc finger protein 236 Neighboring gene uncharacterized LOC102156552 Neighboring gene U6 spliceosomal RNA

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation. Levine GJ, et al. J Vet Intern Med, 2010 Jul-Aug. PMID 20492479
  2. Measurement of myelin basic protein in the cerebrospinal fluid of dogs with degenerative myelopathy. Oji T, et al. Vet Clin Pathol, 2007 Sep. PMID 17806078

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results of the present study indicate that in dogs with thoracolumbar acute thoracolumbar intervertebral disk herniation, CSF MBP concentration was associated with long-term functional outcome
    Title: Cerebrospinal fluid myelin basic protein as a prognostic biomarker in dogs with thoracolumbar intervertebral disk herniation.
  2. The concentration of MBP in the cerebrospinal fluid as a biological marker of degenerative myelopathy in dogs is reported.
    Title: Measurement of myelin basic protein in the cerebrospinal fluid of dogs with degenerative myelopathy.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables structural constituent of myelin sheath IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in myelination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell periphery IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in compact myelin IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in internode region of axon IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in neuronal cell body IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
myelin basic protein

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    2644339..2759352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653861.1 → XP_038509789.1  myelin basic protein isoform X1

    UniProtKB/TrEMBL
    A0A8I3MF11, A0A8P0NWT5, A0A8P0P208
    Related
    ENSCAFP00845000371.1, ENSCAFT00845000541.1
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 326
    Myelin_MBP; Myelin basic protein

  2. XM_038653862.1 → XP_038509790.1  myelin basic protein isoform X2

    UniProtKB/TrEMBL
    A0A8I3RP25, A0A8P0N3E7, A0A8P0P208
    Related
    ENSCAFP00845000380.1, ENSCAFT00845000558.1
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 315
    Myelin_MBP; Myelin basic protein

  3. XM_038653864.1 → XP_038509792.1  myelin basic protein isoform X4

    UniProtKB/TrEMBL
    A0A8C0M2G4
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 289
    Myelin_MBP; Myelin basic protein

  4. XM_038653863.1 → XP_038509791.1  myelin basic protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q0G3, A0A8I3MG04
    Related
    ENSCAFP00845000424.1, ENSCAFT00845000611.1
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 300
    Myelin_MBP; Myelin basic protein

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    2689655..2804648
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038465138.1 → XP_038321066.1  myelin basic protein isoform X1

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 326
    Myelin_MBP; Myelin basic protein

  2. XM_038465139.1 → XP_038321067.1  myelin basic protein isoform X2

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 315
    Myelin_MBP; Myelin basic protein

  3. XM_038465141.1 → XP_038321069.1  myelin basic protein isoform X4

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 289
    Myelin_MBP; Myelin basic protein

  4. XM_038465140.1 → XP_038321068.1  myelin basic protein isoform X3

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 300
    Myelin_MBP; Myelin basic protein

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    2640084..2755067
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590034.1 → XP_038445962.1  myelin basic protein isoform X1

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 326
    Myelin_MBP; Myelin basic protein

  2. XM_038590035.1 → XP_038445963.1  myelin basic protein isoform X2

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 315
    Myelin_MBP; Myelin basic protein

  3. XM_038590037.1 → XP_038445965.1  myelin basic protein isoform X4

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 289
    Myelin_MBP; Myelin basic protein

  4. XM_038590036.1 → XP_038445964.1  myelin basic protein isoform X3

    Conserved Domains (1) summary
    pfam01669
    Location:148 → 300
    Myelin_MBP; Myelin basic protein

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    2810294..2925302
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038525739.1 → XP_038381667.1  myelin basic protein isoform X1

    UniProtKB/TrEMBL
    A0A8I3MF11, A0A8P0NWT5, A0A8P0P208
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 326
    Myelin_MBP; Myelin basic protein

  2. XM_038525740.1 → XP_038381668.1  myelin basic protein isoform X2

    UniProtKB/TrEMBL
    A0A8I3RP25, A0A8P0N3E7, A0A8P0P208
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 315
    Myelin_MBP; Myelin basic protein

  3. XM_038525742.1 → XP_038381670.1  myelin basic protein isoform X4

    UniProtKB/TrEMBL
    A0A8C0M2G4
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 289
    Myelin_MBP; Myelin basic protein

  4. XM_038525741.1 → XP_038381669.1  myelin basic protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q0G3, A0A8I3MG04
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 300
    Myelin_MBP; Myelin basic protein

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    3844963..3959816
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038464296.1 → XP_038320224.1  myelin basic protein isoform X1

    UniProtKB/TrEMBL
    A0A8I3MF11, A0A8P0NWT5, A0A8P0P208
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 326
    Myelin_MBP; Myelin basic protein

  2. XM_038464319.1 → XP_038320247.1  myelin basic protein isoform X2

    UniProtKB/TrEMBL
    A0A8I3RP25, A0A8P0N3E7, A0A8P0P208
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 315
    Myelin_MBP; Myelin basic protein

  3. XM_038464388.1 → XP_038320316.1  myelin basic protein isoform X4

    UniProtKB/TrEMBL
    A0A8C0M2G4
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 289
    Myelin_MBP; Myelin basic protein

  4. XM_038464356.1 → XP_038320284.1  myelin basic protein isoform X3

    UniProtKB/TrEMBL
    A0A8C0Q0G3, A0A8I3MG04
    Conserved Domains (1) summary
    pfam01669
    Location:148 → 300
    Myelin_MBP; Myelin basic protein
Nucleotide Protein
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