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DOCK8 dedicator of cytokinesis 8 [ Canis lupus familiaris (dog) ]

Gene ID: 476333, updated on 5-Mar-2024

Summary

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Official Symbol
DOCK8provided by VGNC
Official Full Name
dedicator of cytokinesis 8provided by VGNC
Primary source
VGNC:VGNC:40052
See related
Ensembl:ENSCAFG00845001647
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
51
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (89701521..89930127)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (89621978..89850471)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (89820804..90055669)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (89347665..89576215)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (89059801..89288656)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene forkhead box protein D4-like Neighboring gene Zn regulated GTPase metalloprotein activator 1 Neighboring gene KN motif and ankyrin repeat domains 1 Neighboring gene uncharacterized LOC119870839 Neighboring gene uncharacterized LOC119869545

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables guanyl-nucleotide exchange factor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in positive regulation of GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of T cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of establishment of T cell polarity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in small GTPase-mediated signal transduction IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cell leading edge IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dedicator of cytokinesis protein 8; LOW QUALITY PROTEIN: dedicator of cytokinesis protein 8

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    89701521..89930127
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038655262.1 → XP_038511190.1  dedicator of cytokinesis protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LN09, A0A8C0N5V5, A0A8I3MME8
    Related
    ENSCAFP00845002298.1, ENSCAFT00845002883.1
    Conserved Domains (3) summary
    cd08696
    Location:559 → 739
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1638 → 2059
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:56 → 166
    DUF3398; Domain of unknown function (DUF3398)

  2. XM_038655263.1 → XP_038511191.1  dedicator of cytokinesis protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q2V3, A0A8I3MJQ9
    Related
    ENSCAFP00845002373.1, ENSCAFT00845002978.1
    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  3. XM_038655264.1 → XP_038511192.1  dedicator of cytokinesis protein 8 isoform X2

    UniProtKB/TrEMBL
    A0A8C0Q2V3, A0A8I3MJQ9
    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  4. XM_038655265.1 → XP_038511193.1  dedicator of cytokinesis protein 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R8M3
    Conserved Domains (2) summary
    cd08696
    Location:194 → 374
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1273 → 1694
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    89347665..89576215
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038466454.1 → XP_038322382.1  dedicator of cytokinesis protein 8 isoform X1

    Conserved Domains (3) summary
    cd08696
    Location:559 → 739
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1638 → 2059
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:56 → 166
    DUF3398; Domain of unknown function (DUF3398)

  2. XM_038466455.1 → XP_038322383.1  dedicator of cytokinesis protein 8 isoform X2

    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  3. XM_038466456.1 → XP_038322384.1  dedicator of cytokinesis protein 8 isoform X2

    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  4. XM_038466457.1 → XP_038322385.1  dedicator of cytokinesis protein 8 isoform X3

    Conserved Domains (2) summary
    cd08696
    Location:194 → 374
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1273 → 1694
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    89059801..89288656
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038591460.1 → XP_038447388.1  dedicator of cytokinesis protein 8 isoform X1

    Conserved Domains (3) summary
    cd08696
    Location:559 → 739
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1638 → 2059
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:56 → 166
    DUF3398; Domain of unknown function (DUF3398)

  2. XM_038591461.1 → XP_038447389.1  dedicator of cytokinesis protein 8 isoform X2

    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  3. XM_038591462.1 → XP_038447390.1  dedicator of cytokinesis protein 8 isoform X2

    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:1 → 98
    DUF3398; Domain of unknown function (DUF3398)

  4. XM_038591463.1 → XP_038447391.1  dedicator of cytokinesis protein 8 isoform X3

    Conserved Domains (2) summary
    cd08696
    Location:194 → 374
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1273 → 1694
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    89820804..90055669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038527147.1 → XP_038383075.1  LOW QUALITY PROTEIN: dedicator of cytokinesis protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8C0LN09, A0A8C0N5V5, A0A8I3MME8
    Conserved Domains (3) summary
    cd08696
    Location:559 → 739
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1638 → 2059
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:56 → 166
    DUF3398; Domain of unknown function (DUF3398)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    89621978..89850471
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038590975.1 → XP_038446903.1  dedicator of cytokinesis protein 8 isoform X1

    UniProtKB/TrEMBL
    A0A8P0P0E7, A0A8P0P9W7
    Conserved Domains (3) summary
    cd08696
    Location:559 → 739
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1638 → 2059
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:56 → 166
    DUF3398; Domain of unknown function (DUF3398)

  2. XM_005615889.4 → XP_005615946.1  dedicator of cytokinesis protein 8 isoform X2

    See identical proteins and their annotated locations for XP_005615946.1

    UniProtKB/TrEMBL
    A0A8P0SZC1
    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:5 → 96
    DUF3398; Domain of unknown function (DUF3398)

  3. XM_533535.7 → XP_533535.4  dedicator of cytokinesis protein 8 isoform X2

    See identical proteins and their annotated locations for XP_533535.4

    UniProtKB/TrEMBL
    A0A8P0SZC1
    Conserved Domains (3) summary
    cd08696
    Location:491 → 671
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1570 → 1991
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
    pfam11878
    Location:5 → 96
    DUF3398; Domain of unknown function (DUF3398)

  4. XM_022421527.2 → XP_022277235.1  dedicator of cytokinesis protein 8 isoform X3

    UniProtKB/TrEMBL
    A0A8C0R8M3
    Conserved Domains (2) summary
    cd08696
    Location:194 → 374
    C2_Dock-C; C2 domains found in Dedicator Of CytoKinesis (Dock) class C proteins
    cd11701
    Location:1273 → 1694
    DHR2_DOCK8; Dock Homology Region 2, a GEF domain, of Class C Dedicator of Cytokinesis 8
Nucleotide Protein
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