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VLDLR very low density lipoprotein receptor [ Canis lupus familiaris (dog) ]

Gene ID: 476336, updated on 5-Mar-2024

Summary

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Official Symbol
VLDLRprovided by VGNC
Official Full Name
very low density lipoprotein receptorprovided by VGNC
Primary source
VGNC:VGNC:48269
See related
Ensembl:ENSCAFG00845002345
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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See VLDLR in Genome Data Viewer
Location:
chromosome: 1
Exon count:
19
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (91786552..91821587)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (91709985..91740404)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (91920678..91951114)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (91433922..91464358)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (91145967..91176393)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Neighboring gene uncharacterized LOC119870840 Neighboring gene nmrA-like family domain-containing protein 1 Neighboring gene uncharacterized LOC111096835 Neighboring gene potassium voltage-gated channel modifier subfamily V member 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM). Gerber M, et al. PLoS One, 2015. PMID 25668033, Free PMC Article
  2. Comparative radiation hybrid map of canine chromosome 1 incorporating SNP and indel polymorphisms. Housley DJ, et al. Genomics, 2004 Aug. PMID 15233990

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. VLDLR:c.1713delC causes cerebellar hypoplasia resembling a Dandy-Walker-like malformation in Eurasier dogs.
    Title: A deletion in the VLDLR gene in Eurasier dogs with cerebellar hypoplasia resembling a Dandy-Walker-like malformation (DWLM).
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
very low-density lipoprotein receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001286978.1 → NP_001273907.1  very low-density lipoprotein receptor precursor

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000354
    UniProtKB/TrEMBL
    A0A8C0N5Z3, A0A8I3RQN7, A0A8P0TU47
    Related
    ENSCAFP00845003367.1, ENSCAFT00845004212.1
    Conserved Domains (7) summary
    smart00192
    Location:71 → 103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:505 → 547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396 → 426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:33 → 67
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:237 → 273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:568 → 608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360 → 390
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    91786552..91821587
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038653490.1 → XP_038509418.1  very low-density lipoprotein receptor isoform X1

    UniProtKB/TrEMBL
    A0A8C0LSZ2, A0A8C0LX46, A0A8C0QCS9, A0A8I3MFA4, A0A8P0TP72
    Related
    ENSCAFP00845003381.1, ENSCAFT00845004233.1
    Conserved Domains (7) summary
    smart00192
    Location:71 → 103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:505 → 547
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:396 → 426
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:33 → 67
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:237 → 273
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:568 → 608
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:360 → 390
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  2. XM_038653491.1 → XP_038509419.1  very low-density lipoprotein receptor isoform X2

    UniProtKB/TrEMBL
    A0A8C0N420, A0A8C0N8P3
    Conserved Domains (7) summary
    smart00192
    Location:71 → 103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:464 → 506
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:355 → 385
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:33 → 67
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:196 → 232
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:527 → 567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:319 → 349
    FXa_inhibition; Coagulation Factor Xa inhibitory site

  3. XM_038653492.1 → XP_038509420.1  very low-density lipoprotein receptor isoform X3

    UniProtKB/TrEMBL
    A0A8I3MF94, A0A8I3MSV0, A0A8P0NMC0, A0A8P0NUR6
    Related
    ENSCAFP00845003320.1, ENSCAFT00845004150.1
    Conserved Domains (7) summary
    smart00192
    Location:71 → 103
    LDLa; Low-density lipoprotein receptor domain class A
    smart00135
    Location:464 → 506
    LY; Low-density lipoprotein-receptor YWTD domain
    smart00179
    Location:355 → 385
    EGF_CA; Calcium-binding EGF-like domain
    cd00112
    Location:33 → 67
    LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
    pfam00057
    Location:196 → 232
    Ldl_recept_a; Low-density lipoprotein receptor domain class A
    pfam00058
    Location:527 → 567
    Ldl_recept_b; Low-density lipoprotein receptor repeat class B
    pfam14670
    Location:319 → 349
    FXa_inhibition; Coagulation Factor Xa inhibitory site

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    91433922..91464358
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    91145967..91176393
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    91920678..91951114
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    91709985..91740404
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

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