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CUL2 cullin 2 [ Canis lupus familiaris (dog) ]

Gene ID: 477952, updated on 5-Mar-2024

Summary

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Official Symbol
CUL2provided by VGNC
Official Full Name
cullin 2provided by VGNC
Primary source
VGNC:VGNC:39729
See related
Ensembl:ENSCAFG00845002080
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 2
Exon count:
29
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 2 NC_051806.1 (2111788..2276949)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 2 NC_006584.4 (1920061..2084989)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 2 NC_049223.1 (2050312..2216547)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 2 NC_049262.1 (1883731..2049588)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 2 NC_049743.1 (1926447..2092740)

Chromosome 2 - NC_051806.1Genomic Context describing neighboring genes Neighboring gene cyclin Y Neighboring gene uncharacterized LOC119870079 Neighboring gene uncharacterized LOC111091150 Neighboring gene cAMP responsive element modulator Neighboring gene axin interactor, dorsalization-associated protein-like Neighboring gene protein SGT1 homolog Neighboring gene uncharacterized LOC119870080 Neighboring gene keratin, type I cytoskeletal 18-like Neighboring gene uncharacterized LOC111094492 Neighboring gene uncharacterized LOC119871071 Neighboring gene uncharacterized LOC111091164

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ubiquitin protein ligase binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of Cul2-RING ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of SCF ubiquitin ligase complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
cullin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051806.1 Reference ROS_Cfam_1.0

    Range
    2111788..2276949
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657993.1 → XP_038513921.1  cullin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MLF0, A0A8I3MI69, A0A8I3MM29, A0A8P0TCN5
    Related
    ENSCAFP00845002916.1, ENSCAFT00845003670.1
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 601
    Cullin; Cullin family
    pfam10557
    Location:632 → 692
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_038657985.1 → XP_038513913.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  3. XM_038657983.1 → XP_038513911.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  4. XM_038657988.1 → XP_038513916.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  5. XM_038657987.1 → XP_038513915.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  6. XM_038657986.1 → XP_038513914.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  7. XM_038657992.1 → XP_038513920.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  8. XM_038657984.1 → XP_038513912.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Related
    ENSCAFP00845002885.1, ENSCAFT00845003633.1
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  9. XM_038657989.1 → XP_038513917.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Related
    ENSCAFP00845003037.1, ENSCAFT00845003815.1
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  10. XM_038657991.1 → XP_038513919.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049262.1 Alternate UMICH_Zoey_3.1

    Range
    1883731..2049588
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038468970.1 → XP_038324898.1  cullin-2 isoform X2

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 601
    Cullin; Cullin family
    pfam10557
    Location:632 → 692
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_038468963.1 → XP_038324891.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  3. XM_038468967.1 → XP_038324895.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  4. XM_038468965.1 → XP_038324893.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  5. XM_038468969.1 → XP_038324897.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  6. XM_038468964.1 → XP_038324892.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  7. XM_038468966.1 → XP_038324894.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  8. XM_038468968.1 → XP_038324896.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049743.1 Alternate UNSW_CanFamBas_1.0

    Range
    1926447..2092740
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593914.1 → XP_038449842.1  cullin-2 isoform X2

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 601
    Cullin; Cullin family
    pfam10557
    Location:632 → 692
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_038593907.1 → XP_038449835.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  3. XM_038593905.1 → XP_038449833.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  4. XM_038593910.1 → XP_038449838.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  5. XM_038593909.1 → XP_038449837.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  6. XM_038593908.1 → XP_038449836.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  7. XM_038593913.1 → XP_038449841.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  8. XM_038593906.1 → XP_038449834.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  9. XM_038593911.1 → XP_038449839.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  10. XM_038593912.1 → XP_038449840.1  cullin-2 isoform X1

    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049223.1 Alternate UU_Cfam_GSD_1.0

    Range
    2050312..2216547
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038529677.1 → XP_038385605.1  cullin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MLF0, A0A8I3MI69, A0A8I3MM29, A0A8P0TCN5
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 601
    Cullin; Cullin family
    pfam10557
    Location:632 → 692
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_038529670.1 → XP_038385598.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  3. XM_038529668.1 → XP_038385596.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  4. XM_038529673.1 → XP_038385601.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  5. XM_038529672.1 → XP_038385600.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  6. XM_038529671.1 → XP_038385599.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  7. XM_038529676.1 → XP_038385604.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  8. XM_038529669.1 → XP_038385597.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  9. XM_038529674.1 → XP_038385602.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  10. XM_038529675.1 → XP_038385603.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006584.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    1920061..2084989
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022406087.2 → XP_022261795.1  cullin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8C0MLF0, A0A8I3MI69, A0A8I3MM29, A0A8P0TCN5
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 601
    Cullin; Cullin family
    pfam10557
    Location:632 → 692
    Cullin_Nedd8; Cullin protein neddylation domain

  2. XM_005616938.4 → XP_005616995.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_005616995.1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  3. XM_005616937.4 → XP_005616994.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_005616994.1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  4. XM_535140.7 → XP_535140.2  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_535140.2

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  5. XM_022406067.2 → XP_022261775.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  6. XM_038455510.1 → XP_038311438.1  cullin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  7. XM_005616941.4 → XP_005616998.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_005616998.1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  8. XM_005616940.4 → XP_005616997.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_005616997.1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  9. XM_005616939.4 → XP_005616996.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_005616996.1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain

  10. XM_005616943.4 → XP_005617000.1  cullin-2 isoform X1

    See identical proteins and their annotated locations for XP_005617000.1

    UniProtKB/TrEMBL
    A0A8C0RUX9, A0A8I3MF89, A0A8I3MFB8, A0A8I3RRY3, A0A8P0N6K0, A0A8P0TDF7
    Conserved Domains (2) summary
    pfam00888
    Location:14 → 644
    Cullin; Cullin family
    pfam10557
    Location:675 → 735
    Cullin_Nedd8; Cullin protein neddylation domain
Nucleotide Protein
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