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CRYAB crystallin alpha B [ Canis lupus familiaris (dog) ]

Gene ID: 479441, updated on 5-Mar-2024

Summary

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Official Symbol
CRYABprovided by VGNC
Official Full Name
crystallin alpha Bprovided by VGNC
Primary source
VGNC:VGNC:39635
See related
Ensembl:ENSCAFG00845001876
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
3
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 5 NC_051809.1 (21204772..21208082)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 5 NC_006587.4 (21104096..21107406)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 5 NC_049226.1 (21215316..21218626)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 5 NC_049265.1 (21266069..21269377)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 5 NC_049746.1 (21166521..21169831)

Chromosome 5 - NC_051809.1Genomic Context describing neighboring genes Neighboring gene chromosome 5 C11orf52 homolog Neighboring gene ATP synthase subunit ATP5MPL, mitochondrial-like Neighboring gene heat shock protein family B (small) member 2 Neighboring gene cilia and flagella associated protein 68 Neighboring gene ferredoxin-fold anticodon binding domain containing 1 Neighboring gene ALG9 alpha-1,2-mannosyltransferase Neighboring gene uncharacterized LOC111095839

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Stability of αB-crystallin gene expression in canine mammary gland neoplasms. Should it be considered as circulating tumor cell genetic marker? Chmielewska-Krzesińska M, et al. Pol J Vet Sci, 2019 Sep. PMID 31560457
  2. Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin. Nagaraj RH, et al. Ann N Y Acad Sci, 2005 Jun. PMID 16037235

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. alphaB-crystallin can be a marker of circulating tumor cells in the bloodstream, but for cancers in which basal marker expression occurs and thus not universal for all cancers originating from the mammary gland tissue.
    Title: Stability of αB-crystallin gene expression in canine mammary gland neoplasms. Should it be considered as circulating tumor cell genetic marker?
  2. alphaB-crystallin, a stress protein present in pericytes, can protect them from methylglyoal-mediated apoptosis.
    Title: Dicarbonyl stress and apoptosis of vascular cells: prevention by alphaB-crystallin.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein folding chaperone IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables structural constituent of eye lens IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein refolding IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in response to heat IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-crystallin B chain

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051809.1 Reference ROS_Cfam_1.0

    Range
    21204772..21208082
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038664904.1 → XP_038520832.1  alpha-crystallin B chain

    UniProtKB/TrEMBL
    A0A8C0JXJ4, A0A8C0Q8G4, A0A8I3MR05
    Related
    ENSCAFP00845002609.1, ENSCAFT00845003290.1
    Conserved Domains (2) summary
    cd06498
    Location:67 → 150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:1 → 52
    Crystallin; Alpha crystallin A chain, N terminal

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049265.1 Alternate UMICH_Zoey_3.1

    Range
    21266069..21269377
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038475044.1 → XP_038330972.1  alpha-crystallin B chain

    Conserved Domains (2) summary
    cd06498
    Location:67 → 150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:1 → 52
    Crystallin; Alpha crystallin A chain, N terminal

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049746.1 Alternate UNSW_CanFamBas_1.0

    Range
    21166521..21169831
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038600373.1 → XP_038456301.1  alpha-crystallin B chain

    Conserved Domains (2) summary
    cd06498
    Location:67 → 150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:1 → 52
    Crystallin; Alpha crystallin A chain, N terminal

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049226.1 Alternate UU_Cfam_GSD_1.0

    Range
    21215316..21218626
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038536180.1 → XP_038392108.1  alpha-crystallin B chain

    UniProtKB/TrEMBL
    A0A8C0JXJ4, A0A8C0Q8G4, A0A8I3MR05
    Conserved Domains (2) summary
    cd06498
    Location:67 → 150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:1 → 52
    Crystallin; Alpha crystallin A chain, N terminal

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006587.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    21104096..21107406
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_857165.6 → XP_862258.2  alpha-crystallin B chain

    See identical proteins and their annotated locations for XP_862258.2

    UniProtKB/TrEMBL
    A0A8C0JXJ4, A0A8C0Q8G4, A0A8I3MR05
    Conserved Domains (2) summary
    cd06498
    Location:67 → 150
    ACD_alphaB-crystallin_HspB5; Alpha-crystallin domain found in the small heat shock protein (sHsp) alphaB-crystallin (HspB5, 20kDa). sHsps are molecular chaperones that suppress protein aggregation and protect against cell stress, and are generally active as large oligomers ...
    pfam00525
    Location:1 → 52
    Crystallin; Alpha crystallin A chain, N terminal
Nucleotide Protein
Heading Accession and Version

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