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TNC tenascin C [ Canis lupus familiaris (dog) ]

Gene ID: 481689, updated on 5-Mar-2024

Summary

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Official Symbol
TNCprovided by VGNC
Official Full Name
tenascin Cprovided by VGNC
Primary source
VGNC:VGNC:47646
See related
Ensembl:ENSCAFG00845010582
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 11
Exon count:
30
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 11 NC_051815.1 (70201293..70293471, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 11 NC_006593.4 (67478996..67543867, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 11 NC_049232.1 (69487404..69552684, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 11 NC_049271.1 (68715128..68780124, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 11 NC_049752.1 (68756416..68820385, complement)

Chromosome 11 - NC_051815.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC111097961 Neighboring gene TNF superfamily member 8 Neighboring gene uncharacterized LOC119874050 Neighboring gene uncharacterized LOC111097962

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Increased presence of stromal myofibroblasts and tenascin-C with malignant progression in canine mammary tumors. Yoshimura H, et al. Vet Pathol, 2011 Jan. PMID 20571146
  2. Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells. Mekonnen GA, et al. Vet Pathol, 2007 Nov. PMID 18039893

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The appearance of stromal myofibroblasts and expression of Tn-C were significantly correlated with higher histological grades of malignancy and vascular/lymphatic invasion in simple carcinomas.
    Title: Increased presence of stromal myofibroblasts and tenascin-C with malignant progression in canine mammary tumors.
  2. This study reported the distribution of tenascin-C (TN-C) and the correlation of TN-C with the necro-inflammatory activity and expression of alpha-smooth muscle actin (alpha-SMA), cytokeratin 7 (CK7), and CD3+ T-lymphocytes in canine chronic hepatitis.
    Title: Tenascin-C in chronic canine hepatitis: immunohistochemical localization and correlation with necro-inflammatory activity, fibrotic stage, and expression of alpha-smooth muscle actin, cytokeratin 7, and CD3+ cells.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tenascin
Names
tenascin C (hexabrachion)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001195149.2 → NP_001182078.1  tenascin precursor

    See identical proteins and their annotated locations for NP_001182078.1

    Status: VALIDATED

    Source sequence(s)
    JAAUVH010000356
    UniProtKB/TrEMBL
    A0A8C0S0B7, A0A8I3NF05, A0A8P0N6C4
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1980 → 2189
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051815.1 Reference ROS_Cfam_1.0

    Range
    70201293..70293471 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038680968.1 → XP_038536896.1  tenascin isoform X3

    UniProtKB/TrEMBL
    A0A8I3NSD6, A0A8I3RW59, A0A8P0T564, A0A8P0T8Y3
    Related
    ENSCAFP00845015125.1, ENSCAFT00845019345.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:2072 → 2281
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  2. XM_038680969.1 → XP_038536897.1  tenascin isoform X4

    UniProtKB/TrEMBL
    A0A8C0K0T0
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:2072 → 2281
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  3. XM_038680967.1 → XP_038536895.1  tenascin isoform X2

    UniProtKB/TrEMBL
    A0A8C0QW02, A0A8I3NJF5, A0A8P0PAV3
    Related
    ENSCAFP00845015280.1, ENSCAFT00845019542.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:2072 → 2281
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  4. XM_038680970.1 → XP_038536898.1  tenascin isoform X5

    UniProtKB/TrEMBL
    A0A8C0S0B7, A0A8I3NJZ1, A0A8P0P622
    Related
    ENSCAFP00845015535.1, ENSCAFT00845019842.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:2071 → 2280
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  5. XM_038680966.1 → XP_038536894.1  tenascin isoform X1

    UniProtKB/TrEMBL
    A0A8I3NFV4, A0A8I3NSD6, A0A8P0NNH6, A0A8P0T564
    Related
    ENSCAFP00845014708.1, ENSCAFT00845018837.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:2163 → 2372
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  6. XM_038680971.1 → XP_038536899.1  tenascin isoform X6

    UniProtKB/TrEMBL
    A0A8I3NSD6, A0A8I3RWE2, A0A8P0T564, A0A8P0TA02
    Related
    ENSCAFP00845015647.1, ENSCAFT00845019976.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1981 → 2190
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  7. XM_038680975.1 → XP_038536903.1  tenascin isoform X10

    UniProtKB/TrEMBL
    A0A8C0JZF4
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1889 → 2098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  8. XM_038680974.1 → XP_038536902.1  tenascin isoform X9

    UniProtKB/TrEMBL
    A0A8C0S0B7
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1889 → 2098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  9. XM_038680972.1 → XP_038536900.1  tenascin isoform X7

    UniProtKB/TrEMBL
    A0A8C0S0B7, A0A8I3NF05, A0A8P0N6C4
    Related
    ENSCAFP00845015785.1, ENSCAFT00845020137.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1980 → 2189
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  10. XM_038680977.1 → XP_038536905.1  tenascin isoform X12

    UniProtKB/TrEMBL
    A0A8C0QFG8
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1798 → 2007
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  11. XM_038680973.1 → XP_038536901.1  tenascin isoform X8

    UniProtKB/TrEMBL
    A0A8C0S0B7, A0A8I3N9I4, A0A8P0SZZ7
    Related
    ENSCAFP00845016018.1, ENSCAFT00845020437.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1889 → 2098
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  12. XM_038680978.1 → XP_038536906.1  tenascin isoform X13

    UniProtKB/TrEMBL
    A0A8C0QKQ6
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1708 → 1917
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  13. XM_038680976.1 → XP_038536904.1  tenascin isoform X11

    UniProtKB/TrEMBL
    A0A8C0JZC9, A0A8I3NDY9, A0A8P0NWD3
    Related
    ENSCAFP00845016089.1, ENSCAFT00845020520.1
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1798 → 2007
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

  14. XM_038680979.1 → XP_038536907.1  tenascin isoform X14

    UniProtKB/TrEMBL
    A0A8C0QKQ6
    Conserved Domains (5) summary
    cd00063
    Location:624 → 710
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    pfam18720
    Location:190 → 217
    EGF_Tenascin; Tenascin EGF domain
    pfam00041
    Location:894 → 976
    fn3; Fibronectin type III domain
    pfam00147
    Location:1525 → 1734
    Fibrinogen_C; Fibrinogen beta and gamma chains, C-terminal globular domain
    NF033759
    Location:301 → 611
    exchanger_TraA; outer membrane exchange protein TraA

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049271.1 Alternate UMICH_Zoey_3.1

    Range
    68715128..68780124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049752.1 Alternate UNSW_CanFamBas_1.0

    Range
    68756416..68820385 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049232.1 Alternate UU_Cfam_GSD_1.0

    Range
    69487404..69552684 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006593.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    67478996..67543867 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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