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NKG7 natural killer cell granule protein 7 [ Homo sapiens (human) ]

Gene ID: 4818, updated on 7-Apr-2024

Summary

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Official Symbol
NKG7provided by HGNC
Official Full Name
natural killer cell granule protein 7provided by HGNC
Primary source
HGNC:HGNC:7830
See related
Ensembl:ENSG00000105374 MIM:606008; AllianceGenome:HGNC:7830
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GIG1; GMP-17; p15-TIA-1
Summary
Predicted to be integral component of plasma membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in bone marrow (RPKM 170.3), spleen (RPKM 54.6) and 5 other tissues See more
Orthologs
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Genomic context

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Location:
19q13.41
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (51371620..51372654, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (54460261..54461295, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51874874..51875908, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene electron transfer flavoprotein subunit beta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51869249-51870208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10985 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10986 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:51871167-51872126 Neighboring gene claudin domain containing 2 Neighboring gene uncharacterized LOC124904752 Neighboring gene ReSE screen-validated silencer GRCh37_chr19:51879781-51880038 Neighboring gene lens intrinsic membrane protein 2 Neighboring gene LIM2 and SIGLEC10 antisense RNA 1 Neighboring gene chromosome 19 open reading frame 84

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Characterization of GMP-17, a granule membrane protein that moves to the plasma membrane of natural killer cells following target cell recognition. Medley QG, et al. Proc Natl Acad Sci U S A, 1996 Jan 23. PMID 8570616, Free PMC Article
  2. Characterization of a novel gene (NKG7) on human chromosome 19 that is expressed in natural killer cells and T cells. Turman MA, et al. Hum Immunol, 1993 Jan. PMID 8458737
  3. Molecular cloning and characterization of G-CSF induced gene cDNA. Shimane M, et al. Biochem Biophys Res Commun, 1994 Feb 28. PMID 7510105
  4. The NK cell granule protein NKG7 regulates cytotoxic granule exocytosis and inflammation. Ng SS, et al. Nat Immunol, 2020 Oct. PMID 32839608, Free PMC Article
  5. Spindle Assembly Checkpoint Inhibition Can Resensitize p53-Null Stem Cells to Cancer Chemotherapy. Liu C, et al. Cancer Res, 2019 May 1. PMID 30862715, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in CD4-positive, alpha-beta T cell activation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to protozoan IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in granzyme-mediated programmed cell death signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in inflammatory response IEA
Inferred from Electronic Annotation
more info
  
involved_in killing of cells of another organism IEA
Inferred from Electronic Annotation
more info
  
involved_in natural killer cell degranulation ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in natural killer cell mediated cytotoxicity ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in natural killer cell mediated cytotoxicity directed against tumor cell target ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in positive regulation of inflammatory response ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytolytic granule ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytolytic granule membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
protein NKG7
Names
G-CSF-induced gene 1 protein
GIG-1 protein
granule membrane protein 17
granule membrane protein of 17 kDa
natural killer cell group 7 sequence
natural killer cell protein 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001363693.2 → NP_001350622.1  protein NKG7 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AI313472, BG743982, S69115
    Consensus CDS
    CCDS86796.1
    UniProtKB/TrEMBL
    A0A0B4J2A6
    Related
    ENSP00000468910.1, ENST00000595217.1

  2. NM_005601.4 → NP_005592.1  protein NKG7 isoform 1

    See identical proteins and their annotated locations for NP_005592.1

    Status: VALIDATED

    Source sequence(s)
    AI313472, S69115
    Consensus CDS
    CCDS12830.1
    UniProtKB/Swiss-Prot
    Q16617
    Related
    ENSP00000221978.4, ENST00000221978.10
    Conserved Domains (1) summary
    cl21598
    Location:21 → 149
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    51371620..51372654 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006723228.4 → XP_006723291.1  protein NKG7 isoform X2

    Conserved Domains (1) summary
    cl21598
    Location:50 → 100
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

  2. XM_005258955.4 → XP_005259012.1  protein NKG7 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    54460261..54461295 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054321079.1 → XP_054177054.1  protein NKG7 isoform X2

  2. XM_054321078.1 → XP_054177053.1  protein NKG7 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q16617.1 GenPept UniProtKB/Swiss-Prot:Q16617

Gene LinkOut

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