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DNaseII Deoxyribonuclease II [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48228, updated on 4-Apr-2024

Summary

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Official Symbol
DNaseIIprovided by FlyBase
Official Full Name
Deoxyribonuclease IIprovided by FlyBase
Primary source
FLYBASE:FBgn0000477
Locus tag
Dmel_CG7780
See related
AllianceGenome:FB:FBgn0000477
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG7780; dDNase II; Dmel\CG7780; DNase; DNase 1; DNase II; DNase-1; DNase1; dnaseII; dnaseII[lo]
Summary
Enables deoxyribonuclease II activity. Involved in nurse cell apoptotic process. Is expressed in several structures, including embryonic/larval fat body; embryonic/larval midgut primordium; endoderm; endoderm anlage; and posterior ectoderm anlage. Orthologous to several human genes including DNASE2 (deoxyribonuclease 2, lysosomal). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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Location:
90E1-90E1; 3-62 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (18019375..18021161)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (13845097..13846883)

Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene Rab3 interacting molecule Neighboring gene uncharacterized protein Neighboring gene couch potato Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. DNase II deficiency impairs innate immune function in Drosophila. Seong CS, et al. Cell Immunol, 2006 Mar. PMID 16854402, Free PMC Article
  2. The characterization of a mutant affecting DNA metabolism in the development of D. melanogaster. Stone JC, et al. Can J Genet Cytol, 1983 Apr. PMID 6406021
  3. Drosophila deoxyribonucleases. I. Variation of deoxyribonucleases in Drosophila melanogaster. Boyd JB. Biochim Biophys Acta, 1969 Jan 7. PMID 5763400
  4. Purification of a lysosomal DNase from Drosophila melanogaster. Gaszner M, et al. Biochem Biophys Res Commun, 1991 Nov 27. PMID 1659816
  5. A genetic and developmental analysis of an acid deoxyribonuclease in Drosophila melanogaster. Detwiler C, et al. Biochem Genet, 1978 Dec. PMID 109079

See all (55) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.
    Title: DNase II mediates a parthanatos-like developmental cell death pathway in Drosophila primordial germ cells.
  2. findings indicate that DNaseII can act cell autonomously to degrade DNA during nonapoptotic cell death.
    Title: Cell-autonomous requirement for DNaseII in nonapoptotic cell death.
  3. These results confirm that DNase II and the ability to clear macromolecular DNA is essential for maintaining proper immune function in Drosophila.
    Title: DNase II deficiency impairs innate immune function in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA endonuclease activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables deoxyribonuclease II activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables deoxyribonuclease II activity IEA
Inferred from Electronic Annotation
more info
  
enables deoxyribonuclease II activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables deoxyribonuclease II activity NAS
Non-traceable Author Statement
more info
 PubMed 
enables deoxyribonuclease II activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA catabolic process TAS
Traceable Author Statement
more info
 PubMed 
involved_in DNA metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in apoptotic DNA fragmentation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nurse cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
deoxyribonuclease II
Names
CG7780-PA
DNaseII-PA
acid DNase
deoxyribonuclease 1
NP_650672.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033777.3 Reference assembly

    Range
    18019375..18021161
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_142415.3 → NP_650672.1  deoxyribonuclease II [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_650672.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7JYM9, Q9VED8
    Related
    FBpp0082962
    Conserved Domains (3) summary
    cd09120
    Location:21 → 164
    PLDc_DNaseII_1; Catalytic domain, repeat 1, of Deoxyribonuclease II and similar proteins
    cd09121
    Location:213 → 362
    PLDc_DNaseII_2; Catalytic domain, repeat 2, of Deoxyribonuclease II and similar proteins
    pfam03265
    Location:24 → 360
    DNase_II; Deoxyribonuclease II
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JYM9 Q7JYM9
Q9VED8 Q9VED8

Gene LinkOut

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