CkIIalpha casein kinase IIalpha [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: CkIIalphaprovided by FlyBase
Official Full Name: casein kinase IIalphaprovided by FlyBase
Primary source: FLYBASE:FBgn0264492
Locus tag: Dmel_CG17520
See related: AllianceGenome:FB:FBgn0264492
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 0958/08; alphaCK2; anon-WO02059370.53; Cask-II-a; CG17520; CJIIalpha; CK II; CK-2; CK-II; CK-II alpha; CK2; CK2 alpha; CK2-alpha; CK2a; ck2alpha; Ck2alpha; CK2alpha; CkII; CKII; CKII alpha; CKII-alpha; CkIIa; CKIIa; CKIIalfa; ckIIalpha; CKIIalpha; dCK2alpha; dCKII; dCKII alpha; Dm-CK2-alpha; DmCK2alpha; DmCKIIalpha; Dmel\CG17520; l(3)S095808; Tik
Summary: Enables protein serine/threonine kinase activity. Involved in several processes, including lateral inhibition; locomotor rhythm; and sensory organ development. Located in cytosol and nucleus. Part of protein kinase CK2 complex. Is expressed in adult head; adult heart; s-LNv neurons; and spermatozoon. Orthologous to several human genes including CSNK2A1 (casein kinase 2 alpha 1). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 80D1-80D1; 3-47 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (23097072..23103460)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (23090172..23096560)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data (including data from studies using transgenic animals) suggest that catalytic activity of casein kinase 2 (CkIIa/CkIIb) is essential for oogenesis in this species; Jabba, a lipid droplet-associated protein and substrate for casein kinase 2, is essential in modulating ovarian lipid metabolism. (CkIIa = casein kinase II alpha subunit; CkIIb = casein kinase II beta subunit)
Title: The protein kinase CK2 substrate Jabba modulates lipid metabolism during Drosophila oogenesis.
CK2alpha might be important in regulating synaptic plasticity by modulating the transcription of BRP. Hence, we propose that CK2alpha is a novel regulator of the active zone protein, BRP, in Drosophila.
Title: CK2α regulates the transcription of BRP in Drosophila.
Coexpressing CK2alpha and CK2beta increases Smo accumulation and induces ectopic Hh target gene expression.
Title: Casein kinase 2 promotes Hedgehog signaling by regulating both smoothened and Cubitus interruptus.
overexpression of Tik elicits ectopic bristles in N(+) flies and suppresses the retinal defects of the gain-of-function allele N(spl).
Title: Functional dissection of Timekeeper (Tik) implicates opposite roles for CK2 and PP2A during Drosophila neurogenesis.
Results describe the isolation of temperature-sensitive alleles of Drosophila CK2alpha.
Title: Drosophila protein kinase CK2 is rendered temperature-sensitive by mutations of highly conserved residues flanking the activation segment.
Coimmunoprecipitation experiments revealed that the alpha-subunit of the protein kinase CK2 (CK2alpha) was associated with soluble Stellate.
Title: Genetically Derepressed Nucleoplasmic Stellate Protein in Spermatocytes of D. melanogaster interacts with the catalytic subunit of protein kinase 2 and carries histone-like lysine-methylated mark.
Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
Title: Dominant-negative CK2alpha induces potent effects on circadian rhythmicity.
casein kinase II has a role in regulating cAMP-response element-binding protein DNA binding by phosphorylation at specific CK sites
Title: Phosphorylation of conserved casein kinase sites regulates cAMP-response element-binding protein DNA binding in Drosophila.
CK2 alpha binds and phosphorylates ribosomal protein L22
Title: Interaction of casein kinase II with ribosomal protein L22 of Drosophila melanogaster.
Sequencing of full-length cDNA encoding subunits in platelets and megakaryocytic cells
Title: Sequencing of full-length cDNA encoding the alpha and beta subunits of human casein kinase II from human platelets and megakaryocytic cells. Expression of the casein kinase IIalpha intronless gene in a megakaryocytic cell line.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm1528 (e-PCR)
- UniSTS:8329

D1S3696 (e-PCR)
- UniSTS:474274

Dm1529 (e-PCR)
- UniSTS:23004

Homology

Orthologs from OrthoDB

Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in aggressive behavior	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in chaeta development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in circadian rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in compound eye development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular mRNA localization involved in pattern specification process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in lateral inhibition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in locomotor rhythm	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic cell cycle	HMP more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IGI Inferred from Genetic Interaction more info	PubMed
involved_in oocyte dorsal/ventral axis specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of smoothened signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein phosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of cell cycle	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
part_of protein kinase CK2 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of protein kinase CK2 complex	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: casein kinase IIalpha

Names: CG17520-PA; CG17520-PB; CG17520-PC; CG17520-PD; CG17520-PE; CG17520-PF; CG17520-PG; CkIIalpha-PA; CkIIalpha-PB; CkIIalpha-PC; CkIIalpha-PD; CkIIalpha-PE; CkIIalpha-PF; CkIIalpha-PG; NAP1-kinase; alpha subunit of drosophila casein kinase II; casein kinase 2; casein kinase II; casein kinase II alpha; casein kinase II alpha subunit; casein kinase II-alpha subunit; lethal (3) S095808; protein kinase CK2; timekeeper

NP_001036624.1

EC 2.7.11.1

NP_001287151.1

EC 2.7.11.1

NP_001287152.1

EC 2.7.11.1

NP_001287153.1

EC 2.7.11.1

NP_524918.1

EC 2.7.11.1

NP_730774.1

EC 2.7.11.1

NP_730775.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

23097072..23103460

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001300224.1 → NP_001287153.1 casein kinase IIalpha, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287153.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
NM_001043159.3 → NP_001036624.1 casein kinase IIalpha, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001036624.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
NM_080179.5 → NP_524918.1 casein kinase IIalpha, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_524918.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Related

FBpp0070042

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
NM_168985.2 → NP_730774.1 casein kinase IIalpha, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730774.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Related

FBpp0070041

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
NM_168986.2 → NP_730775.1 casein kinase IIalpha, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_730775.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Related

FBpp0070043

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
NM_001300222.1 → NP_001287151.1 casein kinase IIalpha, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287151.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
NM_001300223.1 → NP_001287152.1 casein kinase IIalpha, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001287152.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08181, Q0E8B4, Q9W5T2

UniProtKB/TrEMBL

A4V2B8

Conserved Domains (1) summary

cd14132
Location:18 → 322

STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2