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CkIIalpha casein kinase IIalpha [ Drosophila melanogaster (fruit fly) ]

Gene ID: 48448, updated on 28-Aug-2019

Summary

Official Symbol
CkIIalphaprovided by FlyBase
Official Full Name
casein kinase IIalphaprovided by FlyBase
Primary source
FLYBASE:FBgn0264492
Locus tag
Dmel_CG17520
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Holometabola; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
0958/08; alphaCK2; anon-WO02059370.53; Cask-II-a; CG17520; CJIIalpha; CK II; CK-2; CK-II; CK-II alpha; CK2; CK2 alpha; CK2-alpha; CK2a; ck2alpha; Ck2alpha; CK2alpha; CkII; CKII; CKII alpha; CKII-alpha; CkIIa; CKIIa; CKIIalfa; ckIIalpha; CKIIalpha; dCK2alpha; dCKII; dCKII alpha; Dm-CK2-alpha; DmCK2alpha; DmCKIIalpha; Dmel\CG17520; l(3)S095808; Tik

Genomic context

See CkIIalpha in Genome Data Viewer
Location:
80D1-80D1; 3-47 cM
Exon count:
6
Annotation release Status Assembly Chr Location
Release 6.26 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (23097072..23103460)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (23090172..23096560)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene neuromusculin Neighboring gene Ribosomal protein L10 Neighboring gene uncharacterized protein Neighboring gene pseudo

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from BioSystems

  • Mitophagy - animal, organism-specific biosystem (from KEGG)
    Mitophagy - animal, organism-specific biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Mitophagy - animal, conserved biosystem (from KEGG)
    Mitophagy - animal, conserved biosystemMitochondria act as the energy powerhouse of the cell, and are essential for eukaryotic cells to grow and function normally. However, deleterious byproducts of oxidative phosphorylation process calle...
  • Ribosome biogenesis in eukaryotes, organism-specific biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, organism-specific biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Ribosome biogenesis in eukaryotes, conserved biosystem (from KEGG)
    Ribosome biogenesis in eukaryotes, conserved biosystemRibosomes are the cellular factories responsible for making proteins. In eukaryotes, ribosome biogenesis involves the production and correct assembly of four rRNAs and about 80 ribosomal proteins. It...
  • Wnt signaling pathway, organism-specific biosystem (from KEGG)
    Wnt signaling pathway, organism-specific biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...
  • Wnt signaling pathway, conserved biosystem (from KEGG)
    Wnt signaling pathway, conserved biosystemWnt proteins are secreted morphogens that are required for basic developmental processes, such as cell-fate specification, progenitor-cell proliferation and the control of asymmetric cell division, i...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

  • Homologs of the CkIIalpha gene: The CkIIalpha gene is conserved in human, chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, mosquito, C.elegans, S.cerevisiae, K.lactis, E.gossypii, S.pombe, M.oryzae, N.crassa, A.thaliana, and frog.
  • Orthologs
  • Annotated by Drosophila Heterochromatin Genome Project, Lawrence Berkeley National Lab, http://www.dhgp.org

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
ATP binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
axon guidance IMP
Inferred from Mutant Phenotype
more info
PubMed 
chaeta development IMP
Inferred from Mutant Phenotype
more info
PubMed 
circadian rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
compound eye development IMP
Inferred from Mutant Phenotype
more info
PubMed 
intracellular mRNA localization involved in pattern specification process IGI
Inferred from Genetic Interaction
more info
PubMed 
lateral inhibition IMP
Inferred from Mutant Phenotype
more info
PubMed 
locomotor rhythm IMP
Inferred from Mutant Phenotype
more info
PubMed 
mitotic cell cycle HMP PubMed 
negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
oocyte dorsal/ventral axis specification IGI
Inferred from Genetic Interaction
more info
PubMed 
oocyte dorsal/ventral axis specification IMP
Inferred from Mutant Phenotype
more info
PubMed 
peptidyl-serine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
peptidyl-threonine phosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
positive regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of protein stability IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
protein kinase CK2 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein kinase CK2 complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
casein kinase IIalpha
Names
CG17520-PA
CG17520-PB
CG17520-PC
CG17520-PD
CG17520-PE
CG17520-PF
CG17520-PG
CkIIalpha-PA
CkIIalpha-PB
CkIIalpha-PC
CkIIalpha-PD
CkIIalpha-PE
CkIIalpha-PF
CkIIalpha-PG
NAP1-kinase
alpha subunit of drosophila casein kinase II
casein kinase 2
casein kinase II
casein kinase II alpha
casein kinase II alpha subunit
casein kinase II-alpha subunit
lethal (3) S095808
protein kinase CK2
timekeeper
NP_001036624.1
NP_001287151.1
NP_001287152.1
NP_001287153.1
NP_524918.1
NP_730774.1
NP_730775.1

NCBI Reference Sequences (RefSeq)

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    23097072..23103460
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001300224.1NP_001287153.1  casein kinase IIalpha, isoform E [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287153.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0311229, FBtr0344974
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  2. NM_001043159.3NP_001036624.1  casein kinase IIalpha, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001036624.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0110433, FBtr0111141
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  3. NM_080179.5NP_524918.1  casein kinase IIalpha, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_524918.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0070042, FBtr0070043
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  4. NM_168985.2NP_730774.1  casein kinase IIalpha, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730774.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0070041, FBtr0070042
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  5. NM_168986.2NP_730775.1  casein kinase IIalpha, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_730775.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0070043, FBtr0070044
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  6. NM_001300222.1NP_001287151.1  casein kinase IIalpha, isoform F [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287151.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0311359, FBtr0345138
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
  7. NM_001300223.1NP_001287152.1  casein kinase IIalpha, isoform G [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287152.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P08181
    UniProtKB/TrEMBL
    A4V2B8
    Related
    FBpp0311360, FBtr0345139
    Conserved Domains (1) summary
    cd14132
    Location:18322
    STKc_CK2_alpha; Catalytic subunit (alpha) of the Serine/Threonine Kinase, Casein Kinase 2
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