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ACTN4 actinin alpha 4 [ Canis lupus familiaris (dog) ]

Gene ID: 484526, updated on 5-Mar-2024

Summary

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Official Symbol
ACTN4provided by VGNC
Official Full Name
actinin alpha 4provided by VGNC
Primary source
VGNC:VGNC:37550
See related
Ensembl:ENSCAFG00845005045
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 1 NC_051805.1 (114956867..115029926, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 1 NC_006583.4 (113759618..113832649, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 1 NC_049222.1 (115186154..115259191, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 1 NC_049261.1 (114530067..114602907, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 1 NC_049742.1 (114147609..114220650, complement)

Chromosome 1 - NC_051805.1Genomic Context describing neighboring genes Neighboring gene galectin 7B Neighboring gene galectin-7 Neighboring gene calpain 12 Neighboring gene uncharacterized LOC119869347 Neighboring gene uncharacterized LOC111098216 Neighboring gene eukaryotic translation initiation factor 3 subunit K Neighboring gene 5S ribosomal RNA Neighboring gene mitogen-activated protein kinase kinase kinase kinase 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover. Kemp JP Jr, et al. J Biol Chem, 2018 Sep 14. PMID 30049798, Free PMC Article
  2. α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction. Tang VW, et al. J Cell Biol, 2012 Jan 9. PMID 22232703, Free PMC Article
  3. Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturation. Kannan N, et al. J Cell Biol, 2015 Oct 26. PMID 26504173, Free PMC Article
  4. Expression of nephrin, podocin, α-actinin-4 and α3-integrin in canine renal glomeruli. Kobayashi R, et al. J Comp Pathol, 2011 Aug-Oct. PMID 21388638

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. results with alpha-actinin-4 on stress fiber organization are the opposite of what might have been predicted from previous in vitro biochemistry and further highlight how the complex interactions of multiple proteins competing for filament binding lead to unexpected functions for actin-binding proteins in cells
    Title: The actin filament bundling protein α-actinin-4 actually suppresses actin stress fibers by permitting actin turnover.
  2. Knockdown of synaptopodin and alpha-actinin-4 decreases the strength of cell-cell adhesion, reduces the monolayer permeability barrier, and compromises cellular contractility.
    Title: Synaptopodin couples epithelial contractility to α-actinin-4-dependent junction maturation.
  3. alpha-Actinin-4 specifically localized to sites of actin incorporation on purified membranes and at apical junctions in Madin-Darby canine kidney cells.
    Title: α-Actinin-4/FSGS1 is required for Arp2/3-dependent actin assembly at the adherens junction.
  4. aim of this study was to investigate the expression and localization of nephrin, podocin, alpha-actinin-4 and alpha3-integrin in canine renal glomeruli.
    Title: Expression of nephrin, podocin, α-actinin-4 and α3-integrin in canine renal glomeruli.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables actin filament binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in actin cytoskeleton organization IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in muscle cell development IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in Z disc IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell junction IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cell projection IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in cortical actin cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
alpha-actinin-4

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051805.1 Reference ROS_Cfam_1.0

    Range
    114956867..115029926 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038657071.1 → XP_038512999.1  alpha-actinin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0SCJ2
    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_038657067.1 → XP_038512995.1  alpha-actinin-4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0NCF4
    Related
    ENSCAFP00845007128.1, ENSCAFT00845009042.1
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_038657070.1 → XP_038512998.1  alpha-actinin-4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8I3RSG3, A0A8P0SBA5
    Related
    ENSCAFP00845007146.1, ENSCAFT00845009061.1
    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  4. XM_038657066.1 → XP_038512994.1  alpha-actinin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0SAI3, A0A8I3MS75
    Related
    ENSCAFP00845007138.1, ENSCAFT00845009053.1
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  5. XM_038657068.1 → XP_038512996.1  alpha-actinin-4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KYF2, A0A8C0N644
    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049261.1 Alternate UMICH_Zoey_3.1

    Range
    114530067..114602907 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038468216.1 → XP_038324144.1  alpha-actinin-4 isoform X5

    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_038468213.1 → XP_038324141.1  alpha-actinin-4 isoform X2

    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_038468215.1 → XP_038324143.1  alpha-actinin-4 isoform X4

    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  4. XM_038468212.1 → XP_038324140.1  alpha-actinin-4 isoform X1

    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  5. XM_038468214.1 → XP_038324142.1  alpha-actinin-4 isoform X3

    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049742.1 Alternate UNSW_CanFamBas_1.0

    Range
    114147609..114220650 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038593246.1 → XP_038449174.1  alpha-actinin-4 isoform X5

    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_038593243.1 → XP_038449171.1  alpha-actinin-4 isoform X2

    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_038593245.1 → XP_038449173.1  alpha-actinin-4 isoform X4

    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  4. XM_038593242.1 → XP_038449170.1  alpha-actinin-4 isoform X1

    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  5. XM_038593244.1 → XP_038449172.1  alpha-actinin-4 isoform X3

    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049222.1 Alternate UU_Cfam_GSD_1.0

    Range
    115186154..115259191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038528971.1 → XP_038384899.1  alpha-actinin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0SCJ2
    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_038528968.1 → XP_038384896.1  alpha-actinin-4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0NCF4
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_038528970.1 → XP_038384898.1  alpha-actinin-4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8I3RSG3, A0A8P0SBA5
    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  4. XM_038528967.1 → XP_038384895.1  alpha-actinin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0SAI3, A0A8I3MS75
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  5. XM_038528969.1 → XP_038384897.1  alpha-actinin-4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KYF2, A0A8C0N644
    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006583.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    113759618..113832649 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_862275.6 → XP_867368.1  alpha-actinin-4 isoform X5

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0SCJ2
    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  2. XM_005616611.4 → XP_005616668.1  alpha-actinin-4 isoform X2

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0NCF4
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  3. XM_862326.6 → XP_867419.1  alpha-actinin-4 isoform X4

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8I3RSG3, A0A8P0SBA5
    Conserved Domains (5) summary
    COG5126
    Location:762 → 866
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:836 → 902
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  4. XM_541640.7 → XP_541640.2  alpha-actinin-4 isoform X1

    UniProtKB/TrEMBL
    A0A8C0N644, A0A8C0SAI3, A0A8I3MS75
    Conserved Domains (5) summary
    COG5126
    Location:762 → 893
    FRQ1; Ca2+-binding protein, EF-hand superfamily [Signal transduction mechanisms]
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:863 → 929
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family

  5. XM_848317.6 → XP_853410.1  alpha-actinin-4 isoform X3

    UniProtKB/TrEMBL
    A0A8C0KYF2, A0A8C0N644
    Conserved Domains (5) summary
    PTZ00184
    Location:759 → 868
    PTZ00184; calmodulin; Provisional
    cd00176
    Location:414 → 640
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...
    pfam08726
    Location:841 → 907
    EFhand_Ca_insen; Ca2+ insensitive EF hand
    cd21214
    Location:47 → 151
    CH_ACTN_rpt1; first calponin homology (CH) domain found in the alpha-actinin family
    cd21216
    Location:155 → 269
    CH_ACTN_rpt2; second calponin homology (CH) domain found in the alpha-actinin family
Nucleotide Protein
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