MS4A1 membrane spanning 4-domains A1 [Canis lupus familiaris (dog)] - Gene

Summary

Official Symbol: MS4A1provided by VGNC
Official Full Name: membrane spanning 4-domains A1provided by VGNC
Primary source: VGNC:VGNC:52268
See related: Ensembl:ENSCAFG00845020720
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Canis lupus familiaris (sub-species: familiaris)
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Also known as: CD20
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Genomic context

Location:: chromosome: 21

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	ROS_Cfam_1.0 (GCF_014441545.1)	21	NC_051825.1 (51895623..51907069)
106	current	Dog10K_Boxer_Tasha (GCF_000002285.5)	21	NC_006603.4 (50162433..50173865)
106	current	UU_Cfam_GSD_1.0 (GCF_011100685.1)	21	NC_049242.1 (51664248..51675690)
106	current	UMICH_Zoey_3.1 (GCF_005444595.1)	21	NC_049281.1 (50941639..50953065)
106	current	UNSW_CanFamBas_1.0 (GCF_013276365.1)	21	NC_049762.1 (51040140..51051579)

Chromosome 21 - NC_051825.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Our findings indicate that CD47 blockade alone and in combination with anti-CD20 may be an effective strategy for treating canine lymphoma
Title: Eradication of Canine Diffuse Large B-Cell Lymphoma in a Murine Xenograft Model with CD47 Blockade and Anti-CD20.
This study examined the immunoreactivity of a monoclonal antibody to MUM1/IRF4 and compared it with expression of CD79a and CD20 in 109 plasmacytomas in 107 dogs.
Title: Immunohistochemical detection of multiple myeloma 1/interferon regulatory factor 4 (MUM1/IRF-4) in canine plasmacytoma: comparison with CD79a and CD20.
Canine CD20 gene was cloned and sequenced, and the expression of CD20 mRNA was investigated in canine peripheral blood mononuclear cells (PBMCs), and lymph nodes from healthy dogs, and canine lymphoma cells.
Title: Canine CD20 gene.

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General gene information

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Gene Ontology Provided by RefSeq

Process	Evidence Code	Pubs
involved_in cell surface receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in external side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: B-lymphocyte antigen CD20

Names: membrane-spanning 4-domains, subfamily A, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001048028.1 → NP_001041493.1 B-lymphocyte antigen CD20

See identical proteins and their annotated locations for NP_001041493.1

Status: PROVISIONAL

Source sequence(s)

AB210085

UniProtKB/Swiss-Prot

Q3C2E2

UniProtKB/TrEMBL

A0A8C0QD94

Related

ENSCAFP00845028628.1, ENSCAFT00845036583.1

Conserved Domains (1) summary

pfam04103
Location:51 → 216

CD20; CD20-like family

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

NC_051825.1 Reference ROS_Cfam_1.0

Range

51895623..51907069

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_038429506.1 → XP_038285434.1 B-lymphocyte antigen CD20 isoform X1

UniProtKB/TrEMBL

A0A8C0JGQ9, A0A8C0QD94

Conserved Domains (1) summary

pfam04103
Location:51 → 216

CD20; CD20-like family