Hsp60B Heat shock protein 60B [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp60Bprovided by FlyBase
Official Full Name: Heat shock protein 60Bprovided by FlyBase
Primary source: FLYBASE:FBgn0011244
Locus tag: Dmel_CG2830
See related: AllianceGenome:FB:FBgn0011244
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 152031_at; anon-WO0140519.61; CG2830; Dm21D; Dmel\CG2830; Hsp60; hsp60B; Hsp60b; HSP60B; Hsp64; ms(2)06619; ms(2)21D
Summary: Predicted to enable ATP hydrolysis activity and chaperone binding activity. Predicted to be involved in mitochondrial unfolded protein response; mitochondrion organization; and protein folding. Predicted to be active in mitochondrial inner membrane and mitochondrial matrix. Is expressed in adult head; gonad; and spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); autistic disorder; glucose intolerance; hereditary spastic paraplegia (multiple); and hypomyelinating leukodystrophy 4. Orthologous to human HSPD1 (heat shock protein family D (Hsp60) member 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2L	NT_033779.5 (728362..730564)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2L	NT_033779.4 (728362..730564)

Chromosome 2L - NT_033779.5 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	ISS Inferred from Sequence or Structural Similarity more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein-folding chaperone binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in apoptotic mitochondrial changes	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitochondrial unfolded protein response	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein import into mitochondrial intermembrane space	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein refolding	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in mitochondrial inner membrane	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info

Names: CG2830-PA; Hsp 60 related; Hsp60B-PA; heat shock protein 60 related; male sterile(2)21D

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The following sections contain reference sequences that belong to a specific genome build. Explain