Hsp70Aa Heat shock protein 70 Aa [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Hsp70Aaprovided by FlyBase
Official Full Name: Heat shock protein 70 Aaprovided by FlyBase
Primary source: FLYBASE:FBgn0013275
Locus tag: Dmel_CG31366
See related: AllianceGenome:FB:FBgn0013275
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 87A; 87A hsp70; 87A7 hsp70; CG31366; dhsp70; dHsp70; dHSP70; dhsp70Aa; Dm-hsp70; Dmel\CG31366; DmHSP70AA; hs70; hsp 70; Hsp 70; HSP 70; hsp-70; Hsp-70; Hsp-70Aa; hsp70; Hsp70; HSP70; hsp70 87A; hsp70 Aa; hsp70(87A); hsp70a; hsp70A; Hsp70a; Hsp70A; hsp70Aa; HSP70cA1
Summary: Predicted to enable several functions, including ATP binding activity; ATP hydrolysis activity; and misfolded protein binding activity. Involved in heat shock-mediated polytene chromosome puffing and response to hypoxia. Predicted to be active in cytosol; nucleus; and plasma membrane. Is expressed in spermatozoon. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; systemic lupus erythematosus; toxic shock syndrome; type 2 diabetes mellitus; and urinary tract infection. Orthologous to human HSPA1L (heat shock protein family A (Hsp70) member 1 like); HSPA1B (heat shock protein family A (Hsp70) member 1B); and HSPA6 (heat shock protein family A (Hsp70) member 6). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 87A2-87A2; 3-51 cM

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3R	NT_033777.3 (11954163..11956544, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3R	NT_033777.2 (7779885..7782266, complement)

Chromosome 3R - NT_033777.3 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

molecular chaperone Hsp70 and Hsc70 play an indispensable role during Drosophila eye development.
Title: Molecular Chaperone Hsp70 and Its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster.
coactivators CHD1, ISWI, Brm, Kismet-L, INO80, Mi-2, Gcn5, Lid/KDM5, Set1, DART1, DART4, SSRP1, PAF1, and Fs(1)h/Brd4 bind to the promoter of the active hsp70 gene and migrate to its coding region together with elongating RNA polymerase II.
Title: [Coactivator complexes participate in different stages of the Drosophila melanogaster hsp70 gene transcription].
identify the regions of the Hsp70 promoter essential for FOXO-dependent transcription using in vitro methods and find a physiological role for FOXO-dependent expression of heat shock proteins in vivo.
Title: dFOXO Activates Large and Small Heat Shock Protein Genes in Response to Oxidative Stress to Maintain Proteostasis in Drosophila.
We show that while Hsp70 or Hsp83 expression under normal or stress conditions was not affected by AR feeding, Hsp27 levels were elevated in AR-fed wild-type control as well as heat-shocked larvae
Title: Ayurvedic Amalaki Rasayana promotes improved stress tolerance and thus has anti-aging effects in Drosophila melanogaster.
The results suggest that the heat-shock-induced hsp70 transcripts are not destabilized by hsromega-RNAi transgene expression.
Title: Expression of hsrω-RNAi transgene prior to heat shock specifically compromises accumulation of heat shock-induced Hsp70 in Drosophila melanogaster.
We suggest a model describing the process of sequential SWI/SNF complex formation during heat-shock induced transcription of the hsp 70 gene
Title: [SWI/SNF Protein Complexes Participate in the Initiation and Elongation Stages of Drosophila hsp70 Gene Transcription].
Interaction of Spag with both Hsp70 and Hsp90 suggests a model whereby R2TP would accompany clients from Hsp70 to Hsp90 to facilitate their assembly into macromolecular complexes.
Title: Drosophila Spag is the homolog of RNA polymerase II-associated protein 3 (RPAP3) and recruits the heat shock proteins 70 and 90 (Hsp70 and Hsp90) during the assembly of cellular machineries.
Effect on the glial scar formation in neurotransplantation.
Title: Effect of the heat shock protein HSP70 on the glial scar formation in neurotransplantation.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables heat shock protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein folding chaperone	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chaperone cofactor-dependent protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in heat shock-mediated polytene chromosome puffing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein refolding	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to heat	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: heat shock protein 70 Aa

Names: 70 kDa heat shock protein, cytosolic A 1; 87A locus; CG31366-PA; Heat-shock-protein-70Aa; Hsp70Aa-PA; heat shock 70; heat shock protein-70; heat-shock protein 70; hsp70 87A; protein 70

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033777.3 Reference assembly

Range

11954163..11956544 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_169441.2 → NP_731651.1 heat shock protein 70 Aa [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_731651.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P02825, P82910, Q5BI85, Q8MT04, Q95NG7, Q9BIS5

UniProtKB/TrEMBL

F3YDI6

Related

FBpp0081986

Conserved Domains (2) summary

cd10233
Location:3 → 379

HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins

PTZ00009
Location:2 → 642

PTZ00009; heat shock 70 kDa protein; Provisional