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PTK2B protein tyrosine kinase 2 beta [ Canis lupus familiaris (dog) ]

Gene ID: 486102, updated on 5-Mar-2024

Summary

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Official Symbol
PTK2Bprovided by VGNC
Official Full Name
protein tyrosine kinase 2 betaprovided by VGNC
Primary source
VGNC:VGNC:45159
See related
Ensembl:ENSCAFG00845011700
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 25
Exon count:
33
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 25 NC_051829.1 (30327673..30454390, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 25 NC_006607.4 (30723893..30850311, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 25 NC_049246.1 (30305247..30431983, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 25 NC_049285.1 (30257967..30384306, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 25 NC_049766.1 (30138848..30265191, complement)

Chromosome 25 - NC_051829.1Genomic Context describing neighboring genes Neighboring gene epoxide hydrolase 2 Neighboring gene cholinergic receptor nicotinic alpha 2 subunit Neighboring gene uncharacterized LOC111092288 Neighboring gene uncharacterized LOC119865943 Neighboring gene uncharacterized LOC119865944 Neighboring gene tripartite motif containing 35

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in signal complex assembly IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protein-tyrosine kinase 2-beta
Names
PTK2B protein tyrosine kinase 2 beta
XP_005635734.1
XP_005635735.1
XP_022265370.1
XP_038291280.1
XP_038291281.1
XP_038291282.1
XP_038291283.1
XP_038314193.1
XP_038366221.1
XP_038366222.1
XP_038366223.1
XP_038366224.1
XP_038429679.1
XP_038429680.1
XP_038429681.1
XP_038429682.1
XP_038493989.1
XP_038493990.1
XP_038493991.1
XP_038493992.1

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051829.1 Reference ROS_Cfam_1.0

    Range
    30327673..30454390 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038435355.1 → XP_038291283.1  protein-tyrosine kinase 2-beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0KJ58, A0A8C0PBZ5, A0A8C0RSI1, A0A8I3NL72
    Related
    ENSCAFP00845016877.1, ENSCAFT00845021474.1
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:830 → 959
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  2. XM_038435352.1 → XP_038291280.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Related
    ENSCAFP00845016372.1, ENSCAFT00845020851.1
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  3. XM_038435354.1 → XP_038291282.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  4. XM_038435353.1 → XP_038291281.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049285.1 Alternate UMICH_Zoey_3.1

    Range
    30257967..30384306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038510296.1 → XP_038366224.1  protein-tyrosine kinase 2-beta isoform X2

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:830 → 959
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  2. XM_038510293.1 → XP_038366221.1  protein-tyrosine kinase 2-beta isoform X1

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  3. XM_038510295.1 → XP_038366223.1  protein-tyrosine kinase 2-beta isoform X1

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  4. XM_038510294.1 → XP_038366222.1  protein-tyrosine kinase 2-beta isoform X1

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049766.1 Alternate UNSW_CanFamBas_1.0

    Range
    30138848..30265191 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038638064.1 → XP_038493992.1  protein-tyrosine kinase 2-beta isoform X2

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:830 → 959
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  2. XM_038638061.1 → XP_038493989.1  protein-tyrosine kinase 2-beta isoform X1

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  3. XM_038638063.1 → XP_038493991.1  protein-tyrosine kinase 2-beta isoform X1

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  4. XM_038638062.1 → XP_038493990.1  protein-tyrosine kinase 2-beta isoform X1

    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049246.1 Alternate UU_Cfam_GSD_1.0

    Range
    30305247..30431983 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038573754.1 → XP_038429682.1  protein-tyrosine kinase 2-beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0KJ58, A0A8C0PBZ5, A0A8C0RSI1, A0A8I3NL72
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:830 → 959
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  2. XM_038573751.1 → XP_038429679.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  3. XM_038573753.1 → XP_038429681.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  4. XM_038573752.1 → XP_038429680.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006607.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    30723893..30850311 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022409662.2 → XP_022265370.1  protein-tyrosine kinase 2-beta isoform X2

    UniProtKB/TrEMBL
    A0A8C0KJ58, A0A8C0PBZ5, A0A8C0RSI1, A0A8I3NL72
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:830 → 959
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  2. XM_005635677.4 → XP_005635734.1  protein-tyrosine kinase 2-beta isoform X1

    See identical proteins and their annotated locations for XP_005635734.1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  3. XM_038458265.1 → XP_038314193.1  protein-tyrosine kinase 2-beta isoform X1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain

  4. XM_005635678.4 → XP_005635735.1  protein-tyrosine kinase 2-beta isoform X1

    See identical proteins and their annotated locations for XP_005635735.1

    UniProtKB/TrEMBL
    A0A8C0PBH0, A0A8C0R018, A0A8C0RSI1, A0A8I3RYS0
    Conserved Domains (5) summary
    cd05056
    Location:418 → 687
    PTKc_FAK; Catalytic domain of the Protein Tyrosine Kinase, Focal Adhesion Kinase
    smart00295
    Location:41 → 254
    B41; Band 4.1 homologues
    cd13190
    Location:261 → 368
    FERM_C_FAK1; FERM domain C-lobe of Focal Adhesion Kinase 1 and 2
    pfam03623
    Location:872 → 1001
    Focal_AT; Focal adhesion targeting region
    pfam18038
    Location:39 → 137
    FERM_N_2; FERM N-terminal domain
Nucleotide Protein
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