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AIRE autoimmune regulator [ Canis lupus familiaris (dog) ]

Gene ID: 487796, updated on 5-Mar-2024

Summary

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Official Symbol
AIREprovided by VGNC
Official Full Name
autoimmune regulatorprovided by VGNC
Primary source
VGNC:VGNC:37743
See related
Ensembl:ENSCAFG00845019838
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 31
Exon count:
14
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 31 NC_051835.1 (37686832..37697601)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 31 NC_006613.4 (37296701..37307469)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 31 NC_049252.1 (38032729..38043507)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 31 NC_049291.1 (37553994..37564750)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 31 NC_049772.1 (37534760..37545522)

Chromosome 31 - NC_051835.1Genomic Context describing neighboring genes Neighboring gene DNA methyltransferase 3 like Neighboring gene uncharacterized LOC119867031 Neighboring gene phosphofructokinase, liver type Neighboring gene cilia and flagella associated protein 410

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in humoral immune response IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
autoimmune regulator
Names
autoimmune regulator (autoimmune polyendocrinopathy candidiasis ectodermal dystrophy)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051835.1 Reference ROS_Cfam_1.0

    Range
    37686832..37697601
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038443151.1 → XP_038299079.1  autoimmune regulator

    UniProtKB/TrEMBL
    A0A8C0SM14, A0A8I3PI50, A0A8P0NCX4
    Related
    ENSCAFP00845027394.1, ENSCAFT00845034984.1
    Conserved Domains (5) summary
    PTZ00449
    Location:137 → 209
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15539
    Location:335 → 377
    PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
    cd15540
    Location:468 → 509
    PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)
    pfam03172
    Location:54 → 141
    HSR; HSR domain
    cl02536
    Location:234 → 298
    SAND; SAND domain

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049291.1 Alternate UMICH_Zoey_3.1

    Range
    37553994..37564750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038518212.1 → XP_038374140.1  autoimmune regulator

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049772.1 Alternate UNSW_CanFamBas_1.0

    Range
    37534760..37545522
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038645531.1 → XP_038501459.1  autoimmune regulator

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049252.1 Alternate UU_Cfam_GSD_1.0

    Range
    38032729..38043507
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038581151.1 → XP_038437079.1  autoimmune regulator

    UniProtKB/TrEMBL
    A0A8C0SM14

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006613.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    37296701..37307469
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_022413324.2 → XP_022269032.1  autoimmune regulator

    UniProtKB/TrEMBL
    A0A8C0SM14, A0A8I3PI50, A0A8P0NCX4
    Conserved Domains (5) summary
    PTZ00449
    Location:137 → 209
    PTZ00449; 104 kDa microneme/rhoptry antigen; Provisional
    cd15539
    Location:335 → 377
    PHD1_AIRE; PHD finger 1 found in autoimmune regulator (AIRE)
    cd15540
    Location:468 → 509
    PHD2_AIRE; PHD finger 2 found in autoimmune regulator (AIRE)
    pfam03172
    Location:54 → 141
    HSR; HSR domain
    cl02536
    Location:234 → 298
    SAND; SAND domain
Nucleotide Protein
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