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NTF4 neurotrophin 4 [ Homo sapiens (human) ]

Gene ID: 4909, updated on 17-Jun-2019

Summary

Official Symbol
NTF4provided by HGNC
Official Full Name
neurotrophin 4provided by HGNC
Primary source
HGNC:HGNC:8024
See related
Ensembl:ENSG00000225950 MIM:162662
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NT4; NT5; NT-4; NT-5; NTF5; GLC10; GLC1O; NT-4/5
Summary
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
Expression
Biased expression in skin (RPKM 4.5), prostate (RPKM 2.1) and 6 other tissues See more
Orthologs

Genomic context

See NTF4 in Genome Data Viewer
Location:
19q13.33
Exon count:
7
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (49058284..49065076, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (49564323..49568333, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene neurotrophin 4 pseudogene Neighboring gene chorionic gonadotropin subunit beta 7 Neighboring gene potassium voltage-gated channel subfamily A member 7 Neighboring gene RNA, 7SL, cytoplasmic 708, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat The gene expression of neurotrophin 4 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Differentiation Pathway, organism-specific biosystem (from WikiPathways)
    Differentiation Pathway, organism-specific biosystemThis pathway provides an overview of the directed differentiation molecules used to induce early and derivative cell lineages from human pluripotent stem cells. The initial version of this pathway is...
  • MAPK Signaling Pathway, organism-specific biosystem (from WikiPathways)
    MAPK Signaling Pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, organism-specific biosystem (from KEGG)
    MAPK signaling pathway, organism-specific biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • MAPK signaling pathway, conserved biosystem (from KEGG)
    MAPK signaling pathway, conserved biosystemThe mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals e...
  • Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem (from Pathway Interaction Database)
    Neurotrophic factor-mediated Trk receptor signaling, organism-specific biosystem
    Neurotrophic factor-mediated Trk receptor signaling
  • Neurotrophin signaling pathway, organism-specific biosystem (from KEGG)
    Neurotrophin signaling pathway, organism-specific biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • Neurotrophin signaling pathway, conserved biosystem (from KEGG)
    Neurotrophin signaling pathway, conserved biosystemNeurotrophins are a family of trophic factors involved in differentiation and survival of neural cells. The neurotrophin family consists of nerve growth factor (NGF), brain derived neurotrophic facto...
  • p75(NTR)-mediated signaling, organism-specific biosystem (from Pathway Interaction Database)
    p75(NTR)-mediated signaling, organism-specific biosystem
    p75(NTR)-mediated signaling

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
growth factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
activation of phospholipase C activity TAS
Traceable Author Statement
more info
 
adult locomotory behavior ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
epidermis development ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
ganglion mother cell fate determination ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
innervation IEA
Inferred from Electronic Annotation
more info
 
long-term memory ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
mechanoreceptor differentiation IEA
Inferred from Electronic Annotation
more info
 
memory IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
modulation of chemical synaptic transmission IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of neuron apoptotic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nerve growth factor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neurotrophin TRK receptor signaling pathway TAS
Traceable Author Statement
more info
 
peripheral nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulation of neuron differentiation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sensory organ boundary specification ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
taste bud development IEA
Inferred from Electronic Annotation
more info
 
transmembrane receptor protein tyrosine kinase signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
axon IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
dendrite IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
synaptic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
neurotrophin-4
Names
neurotrophic factor 4
neurotrophic factor 5
neurotrophin 5 (neurotrophin 4/5)
neurotrophin-5
neutrophic factor 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_016289.1 RefSeqGene

    Range
    5001..7728
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_006179.4NP_006170.1  neurotrophin-4 preproprotein

    See identical proteins and their annotated locations for NP_006170.1

    Status: REVIEWED

    Source sequence(s)
    AC008687
    Consensus CDS
    CCDS12754.1
    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Related
    ENSP00000469455.1, ENST00000593537.1
    Conserved Domains (1) summary
    pfam00243
    Location:89206
    NGF; Nerve growth factor family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    49058284..49065076 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005258962.3XP_005259019.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_005259019.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89206
    NGF; Nerve growth factor family
  2. XM_006723232.3XP_006723295.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_006723295.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89206
    NGF; Nerve growth factor family
  3. XM_011527009.2XP_011525311.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_011525311.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89206
    NGF; Nerve growth factor family
  4. XM_011527010.2XP_011525312.1  neurotrophin-4 isoform X2

    See identical proteins and their annotated locations for XP_011525312.1

    UniProtKB/Swiss-Prot
    P34130
    UniProtKB/TrEMBL
    A0A024QZE4
    Conserved Domains (1) summary
    pfam00243
    Location:89206
    NGF; Nerve growth factor family
  5. XM_011527008.2XP_011525310.1  neurotrophin-4 isoform X1

    Conserved Domains (1) summary
    pfam00243
    Location:99217
    NGF; Nerve growth factor family

RNA

  1. XR_001753693.1 RNA Sequence

  2. XR_001753694.1 RNA Sequence

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