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DNM1 dynamin 1 [ Canis lupus familiaris (dog) ]

Gene ID: 491319, updated on 5-Mar-2024

Summary

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Official Symbol
DNM1provided by VGNC
Official Full Name
dynamin 1provided by VGNC
Primary source
VGNC:VGNC:51945
See related
Ensembl:ENSCAFG00845029334
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
25
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (56174435..56220232, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (54447720..54493024, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (55340932..55386497, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (54934788..54980303, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (55249424..55295001, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102157251 Neighboring gene SWI5 homologous recombination repair protein Neighboring gene golgin A2 Neighboring gene microRNA mir-199-3 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein Neighboring gene 60S ribosomal protein L30-like Neighboring gene lipocalin 2

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers. Furrow E, et al. J Am Vet Med Assoc, 2013 Mar 15. PMID 23445289
  2. Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds. Minor KM, et al. Vet J, 2011 Aug. PMID 21782486
  3. A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse. Patterson EE, et al. Nat Genet, 2008 Oct. PMID 18806795

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Characteristics of exercised-induced collapse in Labrador Retrievers with various DNM1 genotypes were identified in this study; findings may help distinguish homozygous dogs from those with other types of collapse conditions.
    Title: Relationship between dynamin 1 mutation status and characteristics of recurrent episodes of exercise-induced collapse in Labrador Retrievers.
  2. The frequency of DNM1 mutant allele carriers in Labrador retrievers ranged from 17.9%-38.0% and the frequency of homozygous mutant (EE genotype) individuals ranged from 1.8%-13.6%; 83.6% of EE Labradors were reported to have collapsed by age 4 years.
    Title: Presence and impact of the exercise-induced collapse associated DNM1 mutation in Labrador retrievers and other breeds.
  3. DNM1 mutation is highly associated with the syndrome of exercise-induced collapse.
    Title: A canine DNM1 mutation is highly associated with the syndrome of exercise-induced collapse.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables microtubule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 PubMed 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
dynamin-1
Names
dynanmin 1 protein
NP_001124521.1
XP_038530987.1
XP_038530988.1
XP_038530989.1
XP_038530990.1
XP_038530991.1
XP_038530992.1
XP_038530993.1
XP_038530994.1
XP_038530995.1
XP_038530996.1
XP_038530997.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001131049.1 → NP_001124521.1  dynamin-1

    See identical proteins and their annotated locations for NP_001124521.1

    Status: PROVISIONAL

    Source sequence(s)
    EU682271
    UniProtKB/TrEMBL
    B4YUE0, B4YUE1
    Related
    ENSCAFP00845040883.1, ENSCAFT00845052123.1
    Conserved Domains (7) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    COG0699
    Location:78 → 604
    CrfC; Replication fork clamp-binding protein CrfC (dynamin-like GTPase family) [Replication, recombination and repair]
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam00169
    Location:520 → 623
    PH; PH domain
    pfam01031
    Location:217 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain
    cl23807
    Location:713 → 842
    WWbp; WW-domain ligand protein

RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    56174435..56220232 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038675062.1 → XP_038530990.1  dynamin-1 isoform X4

    UniProtKB/TrEMBL
    B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain
    NF033913
    Location:710 → 863
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  2. XM_038675060.1 → XP_038530988.1  dynamin-1 isoform X2

    UniProtKB/TrEMBL
    B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:751 → 867
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  3. XM_038675069.1 → XP_038530997.1  dynamin-1 isoform X9

    UniProtKB/TrEMBL
    B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 851
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  4. XM_038675068.1 → XP_038530996.1  dynamin-1 isoform X8

    UniProtKB/TrEMBL
    A0A8I3SCA3, B4YUE1
    Related
    ENSCAFP00845040797.1, ENSCAFT00845052001.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  5. XM_038675063.1 → XP_038530991.1  dynamin-1 isoform X5

    UniProtKB/TrEMBL
    A0A8C0SKV4, A0A8I3PZW5, B4YUE1
    Related
    ENSCAFP00845040760.1, ENSCAFT00845051951.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 844
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  6. XM_038675064.1 → XP_038530992.1  dynamin-1 isoform X6

    UniProtKB/TrEMBL
    B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 848
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  7. XM_038675061.1 → XP_038530989.1  dynamin-1 isoform X3

    UniProtKB/TrEMBL
    B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain
    NF033913
    Location:710 → 863
    fibronec_FbpA; LPXTG-anchored fibronectin-binding protein FbpA

  8. XM_038675059.1 → XP_038530987.1  dynamin-1 isoform X1

    UniProtKB/TrEMBL
    B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03247
    Location:747 → 864
    PHA03247; large tegument protein UL36; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  9. XM_038675067.1 → XP_038530995.1  dynamin-1 isoform X7

    UniProtKB/TrEMBL
    A0A8C0RJG4, A0A8I3QSM1, B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  10. XM_038675065.1 → XP_038530993.1  dynamin-1 isoform X7

    UniProtKB/TrEMBL
    A0A8C0RJG4, A0A8I3QSM1, B4YUE1
    Related
    ENSCAFP00845040839.1, ENSCAFT00845052062.1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

  11. XM_038675066.1 → XP_038530994.1  dynamin-1 isoform X7

    UniProtKB/TrEMBL
    A0A8C0RJG4, A0A8I3QSM1, B4YUE1
    Conserved Domains (5) summary
    smart00053
    Location:6 → 245
    DYNc; Dynamin, GTPase
    PHA03378
    Location:752 → 844
    PHA03378; EBNA-3B; Provisional
    cd01256
    Location:520 → 629
    PH_dynamin; Dynamin pleckstrin homology (PH) domain
    pfam01031
    Location:216 → 502
    Dynamin_M; Dynamin central region
    pfam02212
    Location:657 → 745
    GED; Dynamin GTPase effector domain

RNA

  1. XR_005431690.1 RNA Sequence

  2. XR_005431691.1 RNA Sequence

  3. XR_005431687.1 RNA Sequence

  4. XR_005431686.1 RNA Sequence

  5. XR_005431689.1 RNA Sequence

  6. XR_005431685.1 RNA Sequence

  7. XR_005431688.1 RNA Sequence

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    54934788..54980303 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    55249424..55295001 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    55340932..55386497 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    54447720..54493024 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
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