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LCN2 lipocalin 2 [ Canis lupus familiaris (dog) ]

Gene ID: 491320, updated on 5-Mar-2024

Summary

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Official Symbol
LCN2provided by VGNC
Official Full Name
lipocalin 2provided by VGNC
Primary source
VGNC:VGNC:42612
See related
Ensembl:ENSCAFG00845029755
Gene type
protein coding
RefSeq status
MODEL
Organism
Canis lupus familiaris (sub-species: familiaris)
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 9
Exon count:
9
Annotation release Status Assembly Chr Location
106 current ROS_Cfam_1.0 (GCF_014441545.1) 9 NC_051813.1 (56250316..56264670, complement)
106 current Dog10K_Boxer_Tasha (GCF_000002285.5) 9 NC_006591.4 (54522898..54537231, complement)
106 current UU_Cfam_GSD_1.0 (GCF_011100685.1) 9 NC_049230.1 (55416588..55430934, complement)
106 current UMICH_Zoey_3.1 (GCF_005444595.1) 9 NC_049269.1 (55010191..55024522, complement)
106 current UNSW_CanFamBas_1.0 (GCF_013276365.1) 9 NC_049750.1 (55324906..55339237, complement)

Chromosome 9 - NC_051813.1Genomic Context describing neighboring genes Neighboring gene dynamin 1 Neighboring gene microRNA mir-199-3 Neighboring gene CDKN1A interacting zinc finger protein 1 Neighboring gene bublin coiled coil protein Neighboring gene 60S ribosomal protein L30-like Neighboring gene prostaglandin E synthase 2 Neighboring gene solute carrier family 25 member 25 Neighboring gene uncharacterized LOC119873364

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity. Palm CA, et al. J Vet Intern Med, 2016 Jan-Feb. PMID 26725776, Free PMC Article
  2. Neutrophil Gelatinase-Associated Lipocalin in Dogs With Sepsis Undergoing Emergency Laparotomy: A Prospective Case-Control Study. Cortellini S, et al. J Vet Intern Med, 2015 Nov-Dec. PMID 26415728, Free PMC Article
  3. The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases. Hsu WL, et al. BMC Vet Res, 2014 Aug 27. PMID 25160665, Free PMC Article
  4. Expression and the molecular forms of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase 9 in canine mammary tumours. Chen YC, et al. Vet Comp Oncol, 2019 Sep. PMID 31050171
  5. Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells. Konno T, et al. PLoS One, 2016. PMID 27851800, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. It was concluded that NGAL and MMP9 are ubiquitously expressed in canine mammary epithelial cells in normal and cancerous status; however, the NGAL/MMP9 complex exclusively presents in mammary tissues and urine of dogs with tumours.
    Title: Expression and the molecular forms of neutrophil gelatinase-associated lipocalin and matrix metalloproteinase 9 in canine mammary tumours.
  2. the regulation of the expression and function of NGAL in IL-1beta-treated Madin-Darby canine kidney (MDCK) cells, was investigated.
    Title: Expression and Function of Interleukin-1β-Induced Neutrophil Gelatinase-Associated Lipocalin in Renal Tubular Cells.
  3. The urinary NGAL-to-urinary creatinine ratio was early marker of gentamicin-induced acute kidney injury and its decrease documented onset of renal recovery.
    Title: Urinary Neutrophil Gelatinase-associated Lipocalin as a Marker for Identification of Acute Kidney Injury and Recovery in Dogs with Gentamicin-induced Nephrotoxicity.
  4. Serum neutrophil gelatinase-associated lipocalin and urinary creatinine concentration are increased in dogs with sepsis requiring emergency laparotomy.
    Title: Neutrophil Gelatinase-Associated Lipocalin in Dogs With Sepsis Undergoing Emergency Laparotomy: A Prospective Case-Control Study.
  5. This study evaluated the existence of various forms of neutrophil-associated lipocalin in urine and whether these forms were related to the different urinary diseases of dogs.
    Title: The different molecular forms of urine neutrophil gelatinase-associated lipocalin present in dogs with urinary diseases.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables small molecule binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in extracellular space IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
neutrophil gelatinase-associated lipocalin
Names
lipocalin 2 (oncogene 24p3)

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Canis lupus familiaris Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference ROS_Cfam_1.0

Genomic

  1. NC_051813.1 Reference ROS_Cfam_1.0

    Range
    56250316..56264670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038678463.1 → XP_038534391.1  neutrophil gelatinase-associated lipocalin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KRC2
    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_038678464.1 → XP_038534392.1  neutrophil gelatinase-associated lipocalin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KRC2
    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_038678462.1 → XP_038534390.1  neutrophil gelatinase-associated lipocalin isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRC2, A0A8C0SRA0, A0A8I3Q9B0
    Related
    ENSCAFP00845041367.1, ENSCAFT00845052701.1
    Conserved Domains (1) summary
    cl10502
    Location:24 → 196
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

Alternate UMICH_Zoey_3.1

Genomic

  1. NC_049269.1 Alternate UMICH_Zoey_3.1

    Range
    55010191..55024522 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038487292.1 → XP_038343220.1  neutrophil gelatinase-associated lipocalin isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_038487293.1 → XP_038343221.1  neutrophil gelatinase-associated lipocalin isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_038487291.1 → XP_038343219.1  neutrophil gelatinase-associated lipocalin isoform X1

    Conserved Domains (1) summary
    cl10502
    Location:24 → 196
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

Alternate UNSW_CanFamBas_1.0

Genomic

  1. NC_049750.1 Alternate UNSW_CanFamBas_1.0

    Range
    55324906..55339237 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038613163.1 → XP_038469091.1  neutrophil gelatinase-associated lipocalin isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_038613164.1 → XP_038469092.1  neutrophil gelatinase-associated lipocalin isoform X2

    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_038613162.1 → XP_038469090.1  neutrophil gelatinase-associated lipocalin isoform X1

    Conserved Domains (1) summary
    cl10502
    Location:24 → 196
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

Alternate UU_Cfam_GSD_1.0

Genomic

  1. NC_049230.1 Alternate UU_Cfam_GSD_1.0

    Range
    55416588..55430934 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038549219.1 → XP_038405147.1  neutrophil gelatinase-associated lipocalin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KRC2
    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_038549220.1 → XP_038405148.1  neutrophil gelatinase-associated lipocalin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KRC2
    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_038549218.1 → XP_038405146.1  neutrophil gelatinase-associated lipocalin isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRC2, A0A8C0SRA0, A0A8I3Q9B0
    Conserved Domains (1) summary
    cl10502
    Location:24 → 196
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

Alternate Dog10K_Boxer_Tasha Primary Assembly

Genomic

  1. NC_006591.4 Alternate Dog10K_Boxer_Tasha Primary Assembly

    Range
    54522898..54537231 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_038618381.1 → XP_038474309.1  neutrophil gelatinase-associated lipocalin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KRC2
    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  2. XM_038618383.1 → XP_038474311.1  neutrophil gelatinase-associated lipocalin isoform X2

    UniProtKB/TrEMBL
    A0A8C0KRC2
    Conserved Domains (1) summary
    cl10502
    Location:24 → 193
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family

  3. XM_022423770.2 → XP_022279478.1  neutrophil gelatinase-associated lipocalin isoform X1

    UniProtKB/TrEMBL
    A0A8C0KRC2, A0A8C0SRA0, A0A8I3Q9B0
    Conserved Domains (1) summary
    cl10502
    Location:24 → 196
    lipocalin_FABP; lipocalin/cytosolic fatty acid-binding protein family
Nucleotide Protein
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