SERCA Sarco/endoplasmic reticulum Ca(2+)-ATPase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: SERCAprovided by FlyBase
Official Full Name: Sarco/endoplasmic reticulum Ca(2+)-ATPaseprovided by FlyBase
Primary source: FLYBASE:FBgn0263006
Locus tag: Dmel_CG3725
See related: AllianceGenome:FB:FBgn0263006
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 17136664; A4UZU0_DROME; ATC1_DROME; Ca-ATPase; Ca-p; Ca-P60; Ca-P60A; CA-P60A; CaP60A; Ca[2+]ATPase; Ca[2+]P60A; CG3725; Dmel\CG3725; dserca; dSERCA; kum; Kum; l(2)k08308ab; l(2)k09025; l(2)SH0211; serca; Serca; SERCA2; Serca2a
Summary: Predicted to enable P-type calcium transporter activity. Involved in several processes, including calcium ion transport from cytosol to endoplasmic reticulum; intestinal stem cell homeostasis; and positive regulation of ATPase-coupled calcium transmembrane transporter activity. Located in endoplasmic reticulum membrane and sarcoplasmic reticulum. Is expressed in several structures, including extended germ band embryo; gastrula embryo; germline cell; gut section; and muscle system. Used to study Brody myopathy and heart disease. Human ortholog(s) of this gene implicated in Brody myopathy; acrokeratosis verruciformis; essential hypertension; keratosis follicularis; and pulmonary hypertension. Orthologous to several human genes including ATP2A1 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 1) and ATP2A3 (ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 3). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

Location:: 60A11-60A12; 2-105 cM

Exon count:: 13

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	2R	NT_033778.4 (23925077..23935884, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	2R	NT_033778.3 (19812600..19823407, complement)

Chromosome 2R - NT_033778.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
Title: Expanded polyQ aggregates interact with sarco-endoplasmic reticulum calcium ATPase and Drosophila inhibitor of apoptosis protein1 to regulate polyQ mediated neurodegeneration in Drosophila.
SERCA is required for border cell migration by regulating cytoplasmic Ca2+ homeostasis independent of unfolded protein response.
Title: SERCA regulates collective cell migration by maintaining cytoplasmic Ca(2+) homeostasis.
Mutations in SERCA disrupt Wingless signaling by sequestering Armadillo/beta-catenin away from the signaling pool. Elimination of SERCA function results in apoptosis.
Title: Reduced SERCA Function Preferentially Affects Wnt Signaling by Retaining E-Cadherin in the Endoplasmic Reticulum.
Disruption of CaP60A function in Drosophila leads to cardiac dysfunction.
Title: Disruption of sarcoendoplasmic reticulum calcium ATPase function in Drosophila leads to cardiac dysfunction.
A dominant mutation altering SERCA confers temperature-sensitive uncoordination in a gain-of-function manner.
Title: Ionic leakage underlies a gain-of-function effect of dominant disease mutations affecting diverse P-type ATPases.
Heart beat frequency is strikingly reduced in mutant animals following dSERCA inactivation
Title: Conditional mutations in SERCA, the Sarco-endoplasmic reticulum Ca2+-ATPase, alter heart rate and rhythmicity in Drosophila.
Analysis of conditional paralytic mutants in SERCA reveals novel mechanisms for regulating membrane excitability.
Title: Analysis of conditional paralytic mutants in Drosophila sarco-endoplasmic reticulum calcium ATPase reveals novel mechanisms for regulating membrane excitability.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0894 (e-PCR)
- UniSTS:21101

Homology

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables P-type calcium transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type calcium transporter activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adaptive thermogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in calcium ion transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion transport	IEA Inferred from Electronic Annotation more info
involved_in calcium ion transport from cytosol to endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
involved_in calcium ion transport from cytosol to endoplasmic reticulum	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flight behavior	IGI Inferred from Genetic Interaction more info	PubMed
involved_in follicle cell of egg chamber development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in heart contraction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intestinal stem cell homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in intracellular calcium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular calcium ion homeostasis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in intracellular calcium ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in neuromuscular synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of sequestering of calcium ion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in stabilization of membrane potential	IGI Inferred from Genetic Interaction more info	PubMed
involved_in stem cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endomembrane system	HDA more info	PubMed
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed
is_active_in endoplasmic reticulum membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in sarcoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
located_in sarcoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Sarco/endoplasmic reticulum Ca(2+)-ATPase

Names: CG3725-PA; CG3725-PB; CG3725-PC; CG3725-PD; CG3725-PE; CG3725-PF; CG3725-PG; CG3725-PH; CG3725-PI; Ca[2+] ATPase; SERCA-PA; SERCA-PB; SERCA-PC; SERCA-PD; SERCA-PE; SERCA-PF; SERCA-PG; SERCA-PH; SERCA-PI; calcium ATPase; calcium ATPase at 60A; endoplasmic reticulum-specific calcium-transporting ATPase; kumbhakarna; lethal (2) SH0211; organellar-type Ca-ATPase; sarco endoplasmic reticulum calcium-ATPase; sarco/endoplasmic reticulum-type Ca-2+-ATPase; sarcoplasmic endoplasmic reticulum calcium ATPase type 2; serca

NP_001286796.1

EC 7.2.2.10

NP_476832.1

EC 7.2.2.10

NP_726381.1

EC 7.2.2.10

NP_726382.1

EC 7.2.2.10

NP_726383.1

EC 7.2.2.10

NP_726384.1

EC 7.2.2.10

NP_726385.1

EC 7.2.2.10

NP_726386.1

EC 7.2.2.10

NP_726387.1

EC 7.2.2.10

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_033778.4 Reference assembly

Range

23925077..23935884 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001299867.1 → NP_001286796.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform I [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_001286796.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A0B4LGB7

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:5 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 527

Cation_ATPase; Cation transport ATPase (P-type)
NM_057484.3 → NP_476832.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_476832.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P22700

Related

FBpp0072124

Conserved Domains (6) summary

TIGR01116
Location:53 → 989

ATPase-IIA1_Ca; sarco/endoplasmic reticulum calcium-translocating P-type ATPase

pfam00122
Location:92 → 340

E1-E2_ATPase; E1-E2 ATPase

pfam00689
Location:784 → 987

Cation_ATPase_C; Cation transporting ATPase, C-terminus

pfam00690
Location:5 → 72

Cation_ATPase_N; Cation transporter/ATPase, N-terminus

pfam12710
Location:604 → 712

HAD; haloacid dehalogenase-like hydrolase

pfam13246
Location:419 → 527

Cation_ATPase; Cation transport ATPase (P-type)
NM_166639.2 → NP_726387.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform H [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726387.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072125

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_166638.2 → NP_726386.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform G [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726386.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072120

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_166636.2 → NP_726384.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform E [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726384.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072121

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_166633.2 → NP_726381.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726381.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072122

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_166635.2 → NP_726383.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform D [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726383.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072123

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_166634.2 → NP_726382.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726382.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072126

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3
NM_166637.2 → NP_726385.1 Sarco/endoplasmic reticulum Ca(2+)-ATPase, isoform F [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_726385.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A4UZU0, P22700, Q2MGN2, Q95TX1, Q9W1G2, Q9W1G3

UniProtKB/TrEMBL

E8NHA8

Related

FBpp0072127

Conserved Domains (1) summary

cd02083
Location:5 → 989

P-type_ATPase_SERCA; sarco/endoplasmic reticulum Ca(2+)-ATPase (SERCA), similar to mammalian ATP2A1-3/SERCA1-3