Itlnb intelectin b [Mus musculus (house mouse)] - Gene

Summary

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Official Symbol: Itlnbprovided by MGI
Official Full Name: intelectin bprovided by MGI
Primary source: MGI:MGI:3057189
See related: AllianceGenome:MGI:3057189
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Itln2; Itln1b
Summary: Predicted to enable calcium ion binding activity; identical protein binding activity; and oligosaccharide binding activity. Involved in response to nematode. Acts upstream of or within defense response to nematode. Located in extracellular space. Orthologous to human ITLN1 (intelectin 1). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: not in current annotation release
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Genomic context

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Location:: 1; 1 H3

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The responsiveness to Ascaris in mice is likely to be controlled by multiple genes and, despite a unique absence from the susceptible C57BL/6j strain, the Intelectin-2 gene does not play a significant role in resistance.
Title: The role of Intelectin-2 in resistance to Ascaris suum lung larval burdens in susceptible and resistant mouse strains.
Itlnb is increased in expression in the mouse intestinal tract in response to infection with Trichinella spiralis. Mice lacking the Itlnb gene cannot expulse T.spiralis as efficiently. This gene is absent in C57BL/10 mice.
Title: Innate BALB/c enteric epithelial responses to Trichinella spiralis: inducible expression of a novel goblet cell lectin, intelectin-2, and its natural deletion in C57BL/10 mice.

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General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables calcium ion binding	ISO Inferred from Sequence Orthology more info
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oligosaccharide binding	IBA Inferred from Biological aspect of Ancestor more info
enables oligosaccharide binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within defense response to nematode	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of glucose import	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in protein homotrimerization	ISO Inferred from Sequence Orthology more info
involved_in response to nematode	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in side of membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: intelectin-1b

Names: intelectin-2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001007552.1 → NP_001007553.1 intelectin-1b precursor

See identical proteins and their annotated locations for NP_001007553.1

Status: PROVISIONAL

Source sequence(s)

AY217760

UniProtKB/Swiss-Prot

Q80ZA0

UniProtKB/TrEMBL

B2RWY7, B7ZNQ5, D9J347

Conserved Domains (1) summary

cl00085
Location:37 → 82

FReD; Fibrinogen-related domains (FReDs); C terminal globular domain of fibrinogen. Fibrinogen is involved in blood clotting, being activated by thrombin to assemble into fibrin clots. The N-termini of 2 times 3 chains come together to form a globular ...