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B4galt3 beta-1,4-galactosyltransferase 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 494342, updated on 5-Mar-2024

Summary

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Official Symbol
B4galt3provided by RGD
Official Full Name
beta-1,4-galactosyltransferase 3provided by RGD
Primary source
RGD:1359221
See related
Ensembl:ENSRNOG00000003551 AllianceGenome:RGD:1359221
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable galactosyltransferase activity. Predicted to be involved in galactosylceramide biosynthetic process and glycosylation. Predicted to be located in cytosol. Predicted to be active in Golgi apparatus. Orthologous to human B4GALT3 (beta-1,4-galactosyltransferase 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Kidney (RPKM 147.5), Spleen (RPKM 99.6) and 9 other tissues See more
Orthologs
human mouse all
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Genomic context

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Location:
13q24
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (86223827..86229886)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (83691378..83697448)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (89643847..89649880)

Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene Fc epsilon receptor Ig Neighboring gene NADH:ubiquinone oxidoreductase core subunit S2 Neighboring gene ADAM metallopeptidase with thrombospondin type 1 motif, 4 Neighboring gene protoporphyrinogen oxidase Neighboring gene ubiquitin specific peptidase 21

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. A family of human beta4-galactosyltransferases. Cloning and expression of two novel UDP-galactose:beta-n-acetylglucosamine beta1, 4-galactosyltransferases, beta4Gal-T2 and beta4Gal-T3. Almeida R, et al. J Biol Chem, 1997 Dec 19. PMID 9405390
  2. Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT). Gonzalez-Begne M, et al. J Proteome Res, 2009 Mar. PMID 19199708, Free PMC Article
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Gerhard DS, et al. Genome Res, 2004 Oct. PMID 15489334, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC72586

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables N-acetyllactosamine synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables galactosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables galactosyltransferase activity ISO
Inferred from Sequence Orthology
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactosylceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in galactosylceramide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in galactosylceramide biosynthetic process ISO
Inferred from Sequence Orthology
more info
  
involved_in glycosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein glycosylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus ISO
Inferred from Sequence Orthology
more info
  
located_in Golgi cisterna membrane IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
beta-1,4-galactosyltransferase 3
Names
N-acetyllactosamine synthase
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 3
UDP-Gal:betaGlcNAc beta 1,4-galactosyltransferase, polypeptide 3
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 3
b4Gal-T3
beta-1,4-GalTase 3
beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
beta4Gal-T3
nal synthase
neolactotriaosylceramide beta-1,4-galactosyltransferase
NP_001009539.1
XP_006250315.1
XP_006250316.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009539.1 → NP_001009539.1  beta-1,4-galactosyltransferase 3

    See identical proteins and their annotated locations for NP_001009539.1

    Status: PROVISIONAL

    Source sequence(s)
    BC061812
    UniProtKB/Swiss-Prot
    Q6P768
    UniProtKB/TrEMBL
    A0A8I6ADZ3, A6JFW4
    Related
    ENSRNOP00000090652.1, ENSRNOT00000108060.1
    Conserved Domains (1) summary
    cd00899
    Location:124 → 343
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086031.1 Reference GRCr8

    Range
    86223827..86229886
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006250254.5 → XP_006250316.1  beta-1,4-galactosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006250316.1

    UniProtKB/Swiss-Prot
    Q6P768
    UniProtKB/TrEMBL
    A0A8I6ADZ3, A6JFW4
    Conserved Domains (1) summary
    cd00899
    Location:124 → 343
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids

  2. XM_006250253.5 → XP_006250315.1  beta-1,4-galactosyltransferase 3 isoform X1

    See identical proteins and their annotated locations for XP_006250315.1

    UniProtKB/Swiss-Prot
    Q6P768
    UniProtKB/TrEMBL
    A0A8I6ADZ3, A6JFW4
    Related
    ENSRNOP00000004735.4
    Conserved Domains (1) summary
    cd00899
    Location:124 → 343
    b4GalT; Beta-4-Galactosyltransferase is involved in the formation of the poly-N-acetyllactosamine core structures present in glycoproteins and glycosphingolipids
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P768.1 GenPept UniProtKB/Swiss-Prot:Q6P768

Gene LinkOut

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