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Gsta3 glutathione S-transferase alpha 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 494500, updated on 13-Apr-2024

Summary

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Official Symbol
Gsta3provided by RGD
Official Full Name
glutathione S-transferase alpha 3provided by RGD
Primary source
RGD:1591980
See related
Ensembl:ENSRNOG00000056847 AllianceGenome:RGD:1591980
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as
Yc2; Gsta5
Summary
Predicted to enable glutathione transferase activity. Predicted to be involved in glutathione metabolic process and xenobiotic metabolic process. Predicted to act upstream of or within aflatoxin catabolic process and ureteric bud development. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in Liver (RPKM 1222.7), Adrenal (RPKM 500.3) and 3 other tissues See more
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Genomic context

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Location:
9q13
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 9 NC_086027.1 (31154989..31180653)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 9 NC_051344.1 (23658574..23684240)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 9 NC_005108.4 (27357490..27417023)

Chromosome 9 - NC_086027.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102550123 Neighboring gene glutathione S-transferase alpha 3 like 1 Neighboring gene transmembrane protein 14A Neighboring gene makorin ring finger protein 1, pseudogene 1 Neighboring gene uncharacterized LOC108351903 Neighboring gene U6 spliceosomal RNA Neighboring gene glutathione S-transferase alpha 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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Related articles in PubMed

  1. GSTA3 regulates TGF-β1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K-Keap1/Nrf2 pathway. Xiao Y, et al. J Int Med Res, 2019 Nov. PMID 31617428, Free PMC Article
  2. A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis. Chen H, et al. J Transl Med, 2019 Aug 23. PMID 31443720, Free PMC Article
  3. GSTA3 Attenuates Renal Interstitial Fibrosis by Inhibiting TGF-Beta-Induced Tubular Epithelial-Mesenchymal Transition and Fibronectin Expression. Xiao Y, et al. PLoS One, 2016. PMID 27602565, Free PMC Article
  4. Characterization of the rat glutathione S-transferase Yc2 subunit gene, GSTA5: identification of a putative antioxidant-responsive element in the 5'-flanking region of rat GSTA5 that may mediate chemoprotection against aflatoxin B1. Pulford DJ, et al. Biochem J, 1996 Aug 15. PMID 8761455, Free PMC Article
  5. Cloning of cDNAs from fetal rat liver encoding glutathione S-transferase Yc polypeptides. The Yc2 subunit is expressed in adult rat liver resistant to the hepatocarcinogen aflatoxin B1. Hayes JD, et al. J Biol Chem, 1994 Aug 12. PMID 8051171

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GSTA3 inhibited hepatic stellate cell activation and liver fibrosis
    Title: A novel role of glutathione S-transferase A3 in inhibiting hepatic stellate cell activation and rat hepatic fibrosis.
  2. The PI3K-KEAP1/Nrf2-GSTA3 signaling pathway is a possible mechanism of resisting external stimulation of renal fibrosis factors.
    Title: GSTA3 regulates TGF-β1-induced renal interstitial fibrosis in NRK-52E cells as a component of the PI3K-Keap1/Nrf2 pathway.
  3. Protein and mRNA expression of GSTA3 in UUO rats and NRK-52E cells were determined by Western blot and RT-PCR. siRNA and overexpression plasmid were transfected specifically to assess the role of GSTA3 in renal interstitial fibrosis
    Title: GSTA3 Attenuates Renal Interstitial Fibrosis by Inhibiting TGF-Beta-Induced Tubular Epithelial-Mesenchymal Transition and Fibronectin Expression.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Clone Names

  • MGC112704

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables glutathione transferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables glutathione transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in aflatoxin catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glutathione metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ureteric bud development IEA
Inferred from Electronic Annotation
more info
  
involved_in xenobiotic metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
glutathione S-transferase alpha-5
Names
GST A5-5
GST Yc2
glutathione S-transferase A3
glutathione S-transferase Yc2 subunit
NP_001009920.1
NP_001153211.1
NP_001273954.1
XP_038939975.1
XP_038939976.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001009920.2 → NP_001009920.1  glutathione S-transferase alpha-5 isoform 1

    See identical proteins and their annotated locations for NP_001009920.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P46418, Q6LD91
    UniProtKB/TrEMBL
    A6JJ95
    Conserved Domains (2) summary
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  2. NM_001159739.2 → NP_001153211.1  glutathione S-transferase alpha-5 isoform 1

    See identical proteins and their annotated locations for NP_001153211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein (isoform 1).
    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/Swiss-Prot
    P46418, Q6LD91
    UniProtKB/TrEMBL
    A6JJ95
    Related
    ENSRNOP00000074697.2, ENSRNOT00000088416.2
    Conserved Domains (2) summary
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...

  3. NM_001287025.1 → NP_001273954.1  glutathione S-transferase alpha-5 isoform 2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks an alternate 5' exon compared to variant 1 that results in the use of a downstream translation initiation codon. The resulting protein (isoform 2) is shorter and has a distinct N-terminus compared to isoform 1.
    Source sequence(s)
    JAXUCZ010000009
    UniProtKB/TrEMBL
    A0A0G2K8Q5
    Conserved Domains (2) summary
    cd03208
    Location:36 → 170
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cl00388
    Location:1 → 32
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086027.1 Reference GRCr8

    Range
    31154989..31180653
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_039084048.2 → XP_038939976.1  glutathione S-transferase alpha-5 isoform X2

    UniProtKB/TrEMBL
    A0A0G2JVT2, Q498T5
    Related
    ENSRNOP00000069606.2
    Conserved Domains (2) summary
    cl00388
    Location:4 → 82
    Thioredoxin_like; Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
    cl02776
    Location:86 → 139
    GST_C_family; C-terminal, alpha helical domain of the Glutathione S-transferase family

  2. XM_039084047.2 → XP_038939975.1  glutathione S-transferase alpha-5 isoform X1

    UniProtKB/Swiss-Prot
    P46418, Q6LD91
    UniProtKB/TrEMBL
    A6JJ95
    Conserved Domains (2) summary
    cd03208
    Location:86 → 220
    GST_C_Alpha; C-terminal, alpha helical domain of Class Alpha Glutathione S-transferases
    cd03077
    Location:4 → 82
    GST_N_Alpha; GST_N family, Class Alpha subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens, ...
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P46418.2 GenPept UniProtKB/Swiss-Prot:P46418

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