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ODF2 outer dense fiber of sperm tails 2 [ Homo sapiens (human) ]

Gene ID: 4957, updated on 23-Nov-2021

Summary

Official Symbol
ODF2provided by HGNC
Official Full Name
outer dense fiber of sperm tails 2provided by HGNC
Primary source
HGNC:HGNC:8114
See related
Ensembl:ENSG00000136811 MIM:602015
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT134; ODF84; ODF2/1; ODF2/2
Summary
The outer dense fibers are cytoskeletal structures that surround the axoneme in the middle piece and principal piece of the sperm tail. The fibers function in maintaining the elastic structure and recoil of the sperm tail as well as in protecting the tail from shear forces during epididymal transport and ejaculation. Defects in the outer dense fibers lead to abnormal sperm morphology and infertility. This gene encodes one of the major outer dense fiber proteins. Alternative splicing results in multiple transcript variants. The longer transcripts, also known as 'Cenexins', encode proteins with a C-terminal extension that are differentially targeted to somatic centrioles and thought to be crucial for the formation of microtubule organizing centers. [provided by RefSeq, Oct 2010]
Expression
Biased expression in testis (RPKM 95.4), lymph node (RPKM 8.1) and 9 other tissues See more
Orthologs
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Genomic context

See ODF2 in Genome Data Viewer
Location:
9q34.11
Exon count:
26
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (128455185..128501292)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131217464..131263571)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene cerebral endothelial cell adhesion molecule Neighboring gene protein PAT1 homolog 1-like Neighboring gene ODF2 antisense RNA 1 Neighboring gene Sharpr-MPRA regulatory region 9551 Neighboring gene GLE1 RNA export mediator Neighboring gene uncharacterized LOC101929270 Neighboring gene RNA, U7 small nuclear 171 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC9034, FLJ44866, MGC111096

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables structural molecule activity TAS
Traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
involved_in centriole-centriole cohesion IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in cilium organization IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in spermatid development IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of centriolar subdistal appendage IDA
Inferred from Direct Assay
more info
PubMed 
located_in centriole IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in centrosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in centrosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of ciliary transition fiber IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus HDA PubMed 
located_in outer dense fiber IEA
Inferred from Electronic Annotation
more info
 
located_in sperm flagellum ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
outer dense fiber protein 2
Names
cancer/testis antigen 134
cenexin 1
outer dense fiber of sperm tails, 84-kD
sperm tail structural protein
testis tissue sperm-binding protein Li 51e

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029568.1 RefSeqGene

    Range
    5852..51138
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001242352.2NP_001229281.1  outer dense fiber protein 2 isoform 11

    See identical proteins and their annotated locations for NP_001229281.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) uses two alternate splice sites in the 5' coding region, compared to variant 1. The resulting isoform (11) has a shorter N-terminus and contains an additional internal segment compared to isoform 1.
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56590.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    Related
    ENSP00000342581.3, ENST00000351030.7
    Conserved Domains (1) summary
    cl25732
    Location:114798
    SMC_N; RecF/RecN/SMC N terminal domain
  2. NM_001242353.2NP_001229282.1  outer dense fiber protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001229282.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) contains an alternate exon, lacks an exon and uses an alternate splice site in the 5' coding region, compared to variant 1. The resulting isoform (2) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56588.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    Related
    ENSP00000473949.2, ENST00000604420.5
    Conserved Domains (1) summary
    COG1196
    Location:119803
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  3. NM_001242354.2NP_001229283.1  outer dense fiber protein 2 isoform 8

    See identical proteins and their annotated locations for NP_001229283.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) uses an alternate splice site in the 5' coding region, lacks an alternate in-frame exon, and differs in the 3' UTR and coding sequence, compared to variant 1. The resulting isoform (8) is shorter at the N-terminus, lacks an alternate internal segment, and has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56589.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    UniProtKB/TrEMBL
    B4DUU0
    Related
    ENSP00000396687.2, ENST00000448249.7
    Conserved Domains (1) summary
    cl25732
    Location:165485
    SMC_N; RecF/RecN/SMC N terminal domain
  4. NM_001351577.1NP_001338506.1  outer dense fiber protein 2 isoform 12

    Status: REVIEWED

    Source sequence(s)
    AI478559, AL043836, AL445287, BE263555, BM824222, BQ896996, CN368207, DB094573, DC295950, HY281035
    Conserved Domains (1) summary
    cl25732
    Location:202930
    SMC_N; RecF/RecN/SMC N terminal domain
  5. NM_001351578.2NP_001338507.1  outer dense fiber protein 2 isoform 13

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    cl25732
    Location:202886
    SMC_N; RecF/RecN/SMC N terminal domain
  6. NM_001351579.2NP_001338508.1  outer dense fiber protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    cl25732
    Location:241561
    SMC_N; RecF/RecN/SMC N terminal domain
  7. NM_001351580.2NP_001338509.1  outer dense fiber protein 2 isoform 14

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    cl25732
    Location:241561
    SMC_N; RecF/RecN/SMC N terminal domain
  8. NM_001351581.1NP_001338510.1  outer dense fiber protein 2 isoform 15

    Status: REVIEWED

    Source sequence(s)
    AI478559, AK299303, AL445287, DB094573
    Conserved Domains (1) summary
    cl25732
    Location:163847
    SMC_N; RecF/RecN/SMC N terminal domain
  9. NM_001351582.2NP_001338511.1  outer dense fiber protein 2 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    COG1196
    Location:158842
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  10. NM_001351583.2NP_001338512.1  outer dense fiber protein 2 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    cl25732
    Location:222542
    SMC_N; RecF/RecN/SMC N terminal domain
  11. NM_001351584.2NP_001338513.1  outer dense fiber protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56590.1
    Related
    ENSP00000361893.5, ENST00000372807.9
    Conserved Domains (1) summary
    cl25732
    Location:114798
    SMC_N; RecF/RecN/SMC N terminal domain
  12. NM_001351585.2NP_001338514.1  outer dense fiber protein 2 isoform 11

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56590.1
    Conserved Domains (1) summary
    cl25732
    Location:114798
    SMC_N; RecF/RecN/SMC N terminal domain
  13. NM_001351586.2NP_001338515.1  outer dense fiber protein 2 isoform 9

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Related
    ENSP00000394506.2, ENST00000444119.6
    Conserved Domains (1) summary
    COG1196
    Location:95779
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  14. NM_001351587.2NP_001338516.1  outer dense fiber protein 2 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    cl25732
    Location:111745
    SMC_N; RecF/RecN/SMC N terminal domain
  15. NM_001351588.2NP_001338517.1  outer dense fiber protein 2 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL359091, AL445287
    Conserved Domains (1) summary
    cl25732
    Location:92726
    SMC_N; RecF/RecN/SMC N terminal domain
  16. NM_002540.5NP_002531.3  outer dense fiber protein 2 isoform 9

    See identical proteins and their annotated locations for NP_002531.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) contains two alternate exons in the 5' coding region, compared to variant 1. The resulting isoform (9) is shorter at the N-terminus compared to isoform 1.
    Source sequence(s)
    AL359091, AL445287
    UniProtKB/Swiss-Prot
    Q5BJF6
    UniProtKB/TrEMBL
    A0A024R8A5
    Related
    ENSP00000377161.5, ENST00000393527.7
    Conserved Domains (1) summary
    COG1196
    Location:95779
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  17. NM_153432.1NP_702910.1  outer dense fiber protein 2 isoform 3

    See identical proteins and their annotated locations for NP_702910.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting protein (isoform 3) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK093367, AL359091, DB094573, DB511337
    Consensus CDS
    CCDS56586.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    UniProtKB/TrEMBL
    B3KSD5
    Related
    ENSP00000361901.3, ENST00000372814.7
    Conserved Domains (1) summary
    COG1196
    Location:290627
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  18. NM_153433.2NP_702911.1  outer dense fiber protein 2 isoform 2

    See identical proteins and their annotated locations for NP_702911.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple 5' coding region differences, compared to variant 1. The resulting protein (isoform 2) has a distinct N-terminus and is shorter than isoform 1. Variants 2 and 10 both encode the same isoform (2).
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56588.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    Related
    ENSP00000403453.2, ENST00000434106.7
    Conserved Domains (1) summary
    COG1196
    Location:119803
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
  19. NM_153435.1NP_702913.1  outer dense fiber protein 2 isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AL445287, AY366499, DB094573
    UniProtKB/Swiss-Prot
    Q5BJF6
    Conserved Domains (1) summary
    pfam00038
    Location:529857
    Filament; Intermediate filament protein
  20. NM_153436.2NP_702914.1  outer dense fiber protein 2 isoform 4

    See identical proteins and their annotated locations for NP_702914.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 4) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56585.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    Related
    ENSP00000377166.2, ENST00000393533.6
    Conserved Domains (2) summary
    COG1196
    Location:246566
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:104384
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  21. NM_153437.3NP_702915.1  outer dense fiber protein 2 isoform 6

    See identical proteins and their annotated locations for NP_702915.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 6) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS6902.1
    UniProtKB/Swiss-Prot
    Q5BJF6
    UniProtKB/TrEMBL
    A0A024R8A4
    Related
    ENSP00000361877.3, ENST00000372791.7
    Conserved Domains (2) summary
    COG1196
    Location:227547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:85365
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  22. NM_153439.1NP_702917.1  outer dense fiber protein 2 isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR and lacks an in-frame exon in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK301754, AL359091, DB094573, DB511337
    UniProtKB/TrEMBL
    B4DX03
    Conserved Domains (2) summary
    COG1196
    Location:271606
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:129409
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
  23. NM_153440.2NP_702918.1  outer dense fiber protein 2 isoform 7

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR, 3' UTR, and coding region, compared to variant 1. The resulting protein (isoform 7) has distinct N- and C-termini and is shorter than isoform 1.
    Source sequence(s)
    AL359091, AL445287
    Consensus CDS
    CCDS56587.1
    UniProtKB/TrEMBL
    B4DX85
    Related
    ENSP00000437579.1, ENST00000546203.5
    Conserved Domains (2) summary
    COG1196
    Location:227547
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:85365
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    128455185..128501292
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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